Vioxx went mostly to patients who didn't need it, Stanford researcher says
... where use has expanded beyond the narrow clinical situations in which the drugs are most effective and cost-effective." The medical profession has a term for expanding the use of a drug beyond its intended target population: "therapeutic creep." In the case of COX-2s, not only does this expansion mean that mil...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...dency for new drugs to be used in a wider array of situations than supported by scientific studies." The COX-2 inhibitors, introduced early in 1999, were widely promoted as "super aspirin." Ordinary aspirin blocks both COX-2, which triggers inflammation, as well as COX-1, which protects the stomach lining and ...Adding radiation therapy to chemotherapy improves survival in patients with high-risk breast cancer
...ults, and those from other groups, confirm that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that the addition of locoregional radiation therapy is important to achieve the highest cure rate," the authors write. In an editorial, ...Study finds no reduction in breast cancer risk with consumption of vegetables and fruits
...abits. In addition, selection bias is a problem in situations where control participation is less than complete because those controls who participate are likely to be more health conscious and consume greater amounts of vegetables and fruits," the authors write. "The advantages of our cohort study are its size...Physicians' response to religion-related conflicts in medicine
CHICAGO Physicians may encounter situations in which their medical recommendations conflict wi...nt offers moderate possibilities of benefit, or in situations in which treatment is intended to decrease risks of adverse events in the future. The researchers al...Good parent-doctor relationships may improve the advice parents receive
...rove life-saving to children whose home and family situations already make them vulnerable to unintentional injury, the leading cause of death of children over one year of age in this country," says the study's lead author, Catherine Nelson, M.D., M.P.H, a general pediatrics fellow at the Johns Hopkins Children...Very shy children may process some facial expressions differently
...sition toward the avoidance of novel and uncertain situations together with a set of behaviors that indicate shyness and discomfort in social interactions are comprehensively named childhood shyness, or behavioral inhibition (BI). Children with high indexes of shyness-BI are at a heightened risk of developing a...International gathering at UH examines top computer code
...erapeutic uses or industrial and research uses are situations where care has to be taken to understand the effects and minimize exposures with shielding where it is appropriate." FLUKA works by simulating a particular environment in great detail. For example, full-body CT scans are used to assemble very prec...Safety of childbirth after C-section examined
...c uterine rupture - one of the major risks in such situations - occurred in less than 1 percent (124 women or 0.7 percent) of these cases. The study also confirmed that an increased risk of uterine rupture accompanied labor induction, which was evident regardless of the method of induction employed. Among infan...New study shows early ritalin may cause long-term effects on the brain
...one to express despair-like behaviors in stressful situations (such as swim tests) as adults. Overall, the animals showed more evidence of dysfunctional brain reward systems and depressive-like behaviors in adulthood. These findings are critical because they suggest that Ritalin can have long-term consequenc...Increased suicide rate is possibly linked to chemicals released from nearby asphalt plants
...nability to function effectively in work or family situations and, often, a feeling of hopelessness and despair. It is the hopelessness that can lead to suicidal thoughts or actions, Davidson added. A person with a family history of suicide attempts or substance abuse may be at greater risk than ...Money issues leading cause of holiday stress for Americans
...p things in perspective. Try to consider stressful situations in a broader context and keep a long-term perspective. Avoid blowing events out of proportion. Take decisive actions. Instead of letting holiday stressors get the best of you, make a decision to address the underlying cause of a stressful si...Artery variations increase complication risk in liver transplants
...h, that MR angiography is impractical in emergency situations or when a patient is unable to remain still or hold their breath for the exam," he added. Both studies appear in the December 2004 issue of the American Journal of Roentgenology....Learning to cover up reduces risk of skin cancer
... programs can be integrated into existing learning situations and support policy and environmental interventions," Saraiya says. Younger children did better than adolescents. Children in primary school, the Task Force says, "are more receptive than adolescents to practicing self-protective behaviors and are mor...Study examines nature and prevalence of errors in patient care
...ements, and the nursing shortage intensifies, such situations may become more common. Other errors can be attributed to workplace distractions. According to the participants in the study, frequent interruptions from staff, students or even the telephone made administering medications and carrying out other pa...'Plague and Fire' a tale of public health, imperialism, race relations, catastrophe
...rom decimation. "I've always been interested in situations where doctors are prominently involved in the making of public policy," said Mohr, who is an authority on medical jurisprudence. "Here was a case in which three physicians were essentially the absolute dictators of America's newest territorial posses...Pain relief could be easy with a simple injection
...published in the journal Pain Practice, identified situations in which injections of local anesthetic would be the best treatment for pain and reduce unnecessary risk and procedural costs. While the use of sympathetic blocks (injections) is controversial, in this study, 20 patients suffering from complex region...American Thoracic Society journal news tips for November 2004 (second issue)
... researchers, the definition for relapse refers to situations in which a patient becomes and remains culture negative while receiving antituberculosis drugs, but develops active tuberculosis after completion of treatment. The investigators pointed out that a better therapeutic efficacy for daily therapy was no...Subanalysis finds patient-controlled, transdermal pain management system may be comparable
...ts, legal or illicit. This should be considered in situations where the healthcare professional is concerned about an increased risk of misuse, abuse or diversion. Fentanyl can cause life threatening respiratory depression. Inappropriate use of IONSYS TM , or unintended exposure to the fentanyl gel within th......that can monitor a victim's breathing in emergency situations by effectively shrinking an operating room machine into a small, disposable tool that can be carried to a disaster site. NSF-supported researchers at Nanomix, Inc., in Emeryville, Calif., have created a transistor that fuses carbon nanotubes, polyme...