Bayer and Onyx announce new data on dual mechanism of action of BAY 43-9006
... likely results in anti-proliferative effects with slowing or inhibition of tumor cell proliferation. In endothelial cells, BAY 43-9006 exerts an anti-proliferative effect by blocking the VEGFR-2 pathway at two levels: upstream by inhibiting the VEGFR-2 receptor and downstream at the level of Raf kinase. It...Study finds subtle brain damage in some HIV patients on drug therapy
...rain damage may include depression, memory loss, a slowing of mental and physical response time and sluggishness in limb movement. These symptoms can progress to a severe disorder known as HIV dementia, an advanced stage of neurological damage that, before the advent of antiretroviral drug therapy, afflicted...Yerkes researchers discover natural brain chemical reduces effects of cocaine
...ted the importance of CART peptide in combating or slowing down some of the effects of cocaine." The researchers' immediate next steps are to study CART peptide's mechanism of action on the brain, as well as to determine if rodents who have been treated with CART peptide will administer less cocaine to thems...Newer rheumatoid arthritis drugs: Harmful on the liver?
...rheumatoid arthritis are increasingly effective in slowing down this debilitating disease but their side effects can cause other health problems. Dr. Suissa, also a professor at McGill University, and colleagues looked at data obtained from two large American health insurance companies that included 41,885 D...Caregivers refuse Alzheimers medications when patients quality of life threatened
... caregivers are most likely to decline medications slowing Alzheimer's disease if the caregiver assesses the patient's overall quality of life as fair or poor. For example, a husband may decline treatment of his spouse when she can no longer remember family members and can only communicate with them as stra...It's the neighborhood that matters in ALS, according to medical researchers
...s have a protective effect on the damaged neurons, slowing the progression of ALS even when the nerve cells carry the mutant gene. Conversely, the findings that mice with mutant non-neuronal cells develop symptoms of the disease even when the neuronal cells do not carry mutant SOD1 "supports the view that d...High blood pressure does not accelerate age-related cognitive decline
...subjects with high blood pressure showed more of a slowing in cognitive performance tests than did older adults with high blood pressure. According to the researchers, past studies have been epidemiological in nature and have hinted that hypertensive patients perform worse than individuals with normal blood ...Combining osteoporosis treatments does not produce better results
...o treat osteoporosis in men and women and works by slowing bone resorption. Injections of PTH, a treatment initially developed through MGH research, increase bone formation and were approved by the FDA in December 2002 to treat osteoporosis in men and women. Since the two medications work in complementary ...Progress shown in death rates from four leading cancers decline in overall mortality has slowed
...decline in lung cancer rates in men and the recent slowing of an increase in rates in women demonstrate that we can move the trend in the number one cancer killer in the right direction," said John R. Seffrin, Ph.D., chief executive officer of the American Cancer Society (ACS). "Further progress will requir...HIV infection may bump up risk of heart disease in younger patients, UCLA study finds
...asized. "The benefits of antiretroviral therapy in slowing HIV progression and prolonging patients' lives outweigh its possible cardiac risks." Currier pointed out that more studies are needed to investigate whether specific antiretroviral therapy agents contribute to coronary heart-disease risk. "Our study ...To contain health care costs, US must reduce error, modernize administration
...minary evidence that the weakening economy is also slowing health care spending, costs are projected to rise 7 percent annually for the rest of the decade. Davis outlined several steps that could be taken to achieve a high-performance health care system--one that is high-quality, safe, efficient, and accessi...Competition among Medicare health plans not a cure-all
...lment was forecast to grow quickly as a result. By slowing down payments to existing Medicare+Choice plans, however, the federal government caused them to withdraw from many markets, as well as increase premiums and trim benefits. Medicare+Choice also suffered from the same market backlash as commercial mana...Rutgers researcher: Brains in dyslexic children can be 'rewired' to improve reading skills
...ithin words and sentences by exaggerating them and slowing them down. "These are the building blocks you have to have in place before you can learn to read," Tallal said. "I think Fast ForWord is building the scaffolding for reading, and doing it based on scientific knowledge of the most efficient and effect...New HIV vaccine holds promise of global effectiveness
...hat together we can attain the goal of stopping or slowing the AIDS pandemic," he says. "Although thousands have already volunteered to take part in HIV vaccine trials, many more are needed. The importance of community participation cannot be overemphasized," says Dr. Graham. The first phase of the trial,...Hibernating squirrels provide clues for stroke, Parkinson's
...ibernation may have other roles as well, including slowing the aging process. Its potential for helping donated livers, hearts and kidneys remain viable longer until they are transplanted already is being explored by others in clinical trials. Dr. Borlongan, who joined the MCG faculty in February after compl...Pituitary tumor cells in Cushings syndrome found to express large amounts of protein receptor
...ese results indicate that TZDs may be effective in slowing tumor growth in humans," said Dr. Heaney....Multivitamins improve weight gain patterns during pregnancy in HIV-infected women from Tanzania
... improve weight loss patterns in pregnant women by slowing the progression of HIV disease, or by reducing the incidence and severity of secondary infections. The prevention of weight loss is an essential goal of multivitamin supplementation in HIV-infected women because fewer instances of fetal loss, prema...Calcium-blocker drug slows artery clogging better than beta blocker
...anchetti, appears to have the beneficial effect of slowing the growth of cells that line the blood vessels an...other calcium antagonists would be as effective at slowing atherosclerosis. The drug targets dangerous fats that accumulate in the arterial wall and binds wit...Landmark study shows coenzyme Q10 slows progressive decline in Parkinsons disease
... that any nutrient or vitamin might play a role in slowing the progression of PD. The greatest benefits were seen in motor skills and activities of daily living, such as walking, dressing, feeding and bathing. The results of this study will be published in the Oct. 15 issue of the American Medical Associati...Experts highlight cardiovascular and drug interaction risks in elderly patients
...lusively by a single hepatic enzyme family without slowing or accelerating metabolism. Thus, the risk of drug interactions may therefore be less, which should allow physicians to obtain a more predictable drug response. "The selection of granisetron may simplify patient management in addition to reduci...