Mayo Clinic discovery on nature of rheumatoid arthritis lung disease may offer patients therapy
...cells in RA lung disease tissue suggests therapies specifically directed against T cells and T cell function may succeed where earlier therapeutic approaches did not. Explains Dr. Turesson: "This is a rationale for trying newer approaches to treating RA lung disease that involve drugs that block T cell action. Th...Antibiotics protect nerves in mice by turning on genes
... you can find the right drug, you might be able to specifically affect other transporters, too." Because ceftriaxone only protects against glutamate damage, just one problem in ALS, it's not surprising that the mice eventually succumbed to weakness and paralysis despite treatment, he says. "If we can find drugs t...Shepherds whistle while they work and brains process sounds as language
...al brain regions were activated, but none has been specifically implicated in language processing, indicating they did not recognize Silbo as a language, Corina said. The researchers found a similar pattern during the second tasks. While both subjects groups were able to detect the target whistle sound, only the...New protein discovered by Hebrew University researchers
...ill be capable of delivering cell-destroying drugs specifically to certain types of solid cancer tumors. The prote...s tiny structure enables this carrier to penetrate specifically into tumors without harming healthy tissue and thus enhance the effectiveness of chemotherapy. This ...New programme will train the next generation of health leaders
...esponsibilities in their organisation. It is aimed specifically at public health educators in Central and Eastern ...nagement. This course, led by experts and tailored specifically to meet the needs of professionals in these areas, is a vital step towards creating that." Professor...Scientists uncover new mechanism for the amygdala in fear recognition
...ish fear in facial expressions to normal levels by specifically instructing her to look at the eye region. However, this instruction had to be given each time the patient viewed a face otherwise she resumed her abnormal gaze pattern, did not fixate on the eyes and was not able to discern fear. The findings s...Getting pregnant while on the pill: Yet another health hazard of being overweight
...ill is to lose weight, although this study did not specifically examine the impact of weight loss on the pill's effectiveness. "I think losing weight, if one is substantially overweight, is a terrific idea for many health reasons and a laudable goal," Holt said. "I also acknowledge that it is often difficult to d...Special JAMA commentary on lessons learned from troubles with COX-2 inhibitors
...d I concluded: 'it is mandatory to conduct a trial specifically assessing cardiovascular risk and benefit of these agents. Until then, we urge caution in prescribing these agents to patients at risk for cardiovascular morbidity.' Unfortunately, no such trials were ever initiated and the official warnings for th...Mice with depression-like behaviors reveal possible source of human depression
...se glucocorticoid receptors from their forebrains, specifically from the cortex and hippocampus, beginning at about three weeks of age and continuing until they reach a 95 percent loss at six months. The team felt the gradual loss could simulate the time course typical for human development of depression, which c...How platelets help cancer invade other tissues
...s formation. However the authors did not interfere specifically with LPA signaling, leaving open the possibility that this anti-metastatic effect could be due to an LPA-independent pathway. These findings in addition to other data suggest that platelet inhibition may slow the rate of tumor progression and metasta...UGA researchers receive NIH contract to create a stem cell-based drug assay for SMA
...supplement to their existing grant from the NIH to specifically examine the function of SMN in motor neurons. "What our lab is trying to understand is why only spinal motor neurons are affected by a mutation in SMN when the gene is involved in mechanisms required for all cell functioning," said Terns. Outside col...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...EN to Akt3 in melanomas. Robertson found that PTEN specifically regulates Akt3. Consequently, when PTEN is lost, A...ein. In Robertson's study, the siRNA were designed specifically to target Akt3. In addition, he put back the PTEN protein in the melanoma cells. This restarted the ...Scientists turn on the 'gender lens' on cardiovascular disease research
...n Health Sciences. GRACE investigators will focus specifically on two areas: acute coronarysyndrome and the metabolic syndrome, also known as type-2 diabetes linkedwith abdominal obesity. "We will focus on assessing epidemiological studies and clinical trials inthese two important problem areas," said Dr. Anan...Little evidence to link mercury fillings to human health problems
... cognitive dysfunction; neurodegenerative disease, specifically Alzheimer's disease and Parkinson's disease; or autoimmune disease, including multiple sclerosis; Various non-specific complaints attributed to dental amalgam have not been shown to be due to increased mercury release and absorption from dental a...Bulimic teens also likely to suffer from depression
... and dysthymia in teens can help therapists assess specifically for dysthymia in bulimic patients and choose a treatment that will combat both disorders, she says. Perez says that it is possible for adults to suffer from both disorders, but she notes that the patterns between bulimia and dysthymia may chan...Penn epidemiological study shows difference in cardiovascular effects between Vioxx and Celebrex
... first epidemiological study designed and executed specifically to determine the heart-attack risk associated with COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex), researchers at the University of Pennsylvania School of Medicine found a greater risk of heart attack associated with Vioxx than Celebrex,...Choosing the kind of fat to avoid obesity
...sms involved in the regulation of the leptin gene, specifically in the role of glucose metabolism. The awarded research is entitled, 'Increase in oxidation of glucose is involved in the stimulant effect of EPA on leptin secretion primary cultures of adipocites from the rat'....Endocrine Society calls for clinical guidelines on androgens for women
... reviewed by the FDA this week would be designated specifically for women who have undergone a hysterectomy and are taking estrogen therapy. However, future research is needed to better understand how this therapy will impact other populations of women. "The new testosterone treatment will potentially bene...UCSD researchers identify new role for drugs in prevention, treatment of atherosclerosis
...oxisome proliferators-activated receptors (PPARs), specifically PPAR-gamma and PPAR-alpha, have a direct effect in the artery wall that prevents the accumulation of cholesterol in atherosclerotic lesions by up to 70 percent, as compared to untreated mice fed a high cholesterol diet. The scientists also determine......rica (RSNA). "Plus, having physicians who are not specifically trained in imaging could result in a decrease in quality," Dr. Levin added. Dr. Levin and colleagues conducted their research by analyzing procedure, specialty and location codes drawn from the Medicare Part B fee-for-services databases between 1...