Immune cells may play important role in progression of type 1 diabetes, Joslin researchers find
...producing beta cells of the pancreas. At an early stage in this process, white blood cells called T-cells invade the islets of Langerhans of the pancreas, where the beta cells reside (a condition known as "insulitis"). Yet, in both mice and humans, insulitis does not always progress to full-blown type 1 ...Different methods of adjuvant chemotherapy for colorectal cancer have similar outcomes
...al of 1084 patients with colon carcinoma in Dukes' stage B or C who were recruited between 1992 and 1998. After surgery, the patients received the regional regimen, the systemic regimen, or regional followed by systemic chemotherapy. Survival rates after 5 years--74% for the regional regimen, 78% for the ...New global trials help to make FOSRENOL(R) the most extensively studied modern phosphate binder
... Lisbon, which demonstrated that patients with end stage renal disease (ESRD) treated with FOSRENOL can largely avoid the damaging consequences of hyperphosphataemia (excessively high phosphate levels in the blood) seen in as many as 80% of dialysis patients 3 . "Effective management of hyperphosphataemi...On the edge: Are we at risk of an ESRD pandemic?
...he US, demand for renal replacement therapy in end stage renal disease (ESRD) could escalate sharply. "Pati... no doubt that, with diabetes on the increase, end stage renal disease will increase as well. To help our patients stay well, for as long as possible while ...Scents will not rouse us from slumber, says new Brown University study
...t and did not wake any participants in the deepest stage of sleep. Pyridine is a component of coal tar and used as a herbicide for firewood, and thus a likely byproduct of many real fires, according to the authors. However, sound woke the participants regardless of the sleep stage. A moderately loud audit...Emory conference to educate health professionals about 'metabolic syndrome'
... that make up the Metabolic Syndrome at an earlier stage before they result in major health problems such as full-blown diabetes, heart attack and stroke."It's a major challenge for clinicians and scientists to determine the true risk of the particular cardiovascular risk factors and their combinations in ...New research in atrial fibrillation
...rillate," said Dr. Donahue. "This is in an earlier stage of development." "AF is a very active area of research, with a number of very different modes of attack in different stages of development, that should pay off in improved patient care," said Dr. Donahue....UNC study may help predict premature infants at risk of total blindness
...ent recommended treatment for severe ROP preceding stage 4 or retinal detachment is laser ablation of the i...ll leaves a certain number of infants that develop stage 4 ROP, which is early, partial retinal detachment. What we want to do is prevent stage 5 ROP, total ...Breast cancers show 'surprising characteristics' on MRI
...ok like a mass. Most of the cancers (70%) were stage 1 disease; 28% were stage 2, and 2% of the women had distant metastases, indicating that MRI can detect breast cancer at an ea...First multi-center trial shows cryosurgery successful at treating some early-stage breast cancer
... one step closer to clinical application for early stage disease. As mammograms and other imaging technique...ocedure that holds real promise for treating early stage breast cancer," says Michael Sabel, M.D., a surgical oncologist from the University of Michigan Comp...Newly-described route to cancer solves a mystery in lung cancer
... Roth. "This is a very early change that we see in stage one cancer, and carcinoma in situ. We also see it in the lung cells of smokers who do not have cancer." The researchers found that area contains a number of tumor suppressor genes including FUS1 that not only inhibited tumor growth and metastasis, bu...Thoracic PET appropriate for diagnosing some lung cancer patients
...g patients with a single pulmonary nodule or early stage lung cancer, thus reducing radiation exposure to the patient, a new study suggests. The study included 1,026 PET scans ordered for evaluation of a single pulmonary nodule or lung cancer staging. Twenty-six patients had distant metastases found on wh...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
...two-staged clinical trial of 15 patients each. One stage will offer the treatment by injection to patients with recurrent gliomas who cannot be treated with surgery. Progress will be monitored with serial diagnostic scans. In the second stage, patients with a glioma will have the therapy, followed by surge...Researchers define mechanism that enables stem cells to track migrating brain tumor cells
... subpopulation of progenitor cells at a particular stage of differentiation," said Dr. Yu. "Our findings cl...d, the candidate cells appear to be at an advanced stage of differentiation but are not yet mature astrocytes, a subcategory of glial cells. Astrocytes are c...Medical residents report sleep loss and fatigue take toll on learning, work and personal lives
...rn because residency training is such an important stage in the professional development of physicians." "Unfortunately, the strategies residents describe adopting to cope with the effects of sleep loss and fatigue are by trial-and-error. More education is needed to increase awareness of effective strateg...Alternative/supplemental breast imaging methods tested
...malities, including cancer. Results from the first stage of their research, information about the electro-m...elp detect early tumor growth and characterize the stage of a tumor by learning about its vascular makeup....Combination PET/CT should be used to determine stage of non-small cell lung cancer
...nosis, when physicians are trying to determine the stage of the cancer. The seriousness of NSCLC is rated f.... Moreover, the overall process of determining the stage of NSCLC remains difficult, especially in differentiating between N1 and N2 stages of cancer, the Ho...Development of rare esophageal cancer in African-Americans may differ from whites
...etaplasia - 45 percent (9/20) of them had advanced stage disease compared with 22.2 percent (123/554) of whites, according to the Hopkins team. In addition, the overall survival rates in African-Americans were significantly worse than whites, with no African-Americans surviving more than three years. The...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
... be tested as a possible preventive agent in early stage disease and may further be helpful as maintenance therapy. Many researchers at M. D. Anderson, relying on past experience with Iressa as well as current studies, believe the drug will best be used in combination with other targeted therapies, ...NCI grant supports Jefferson trial to study test for colorectal cancer recurrence
...that we discover the recurrence at an early enough stage that we can make a clinical impact on the patient....we find the isolated metastasis at an early enough stage that it is removable by surgery." In a previous NCI-supported trial, the researchers showed that GCC...