Tag: "stromal" at medical news
First effective treatment for gastrointestinal sarcoma seen with multi-center trial of STI-571
...orm of soft-tissue sarcoma called gastrointestinal stromal
tumors (GIST). Although this is not a common tumo...e tissue such as muscle and fat. Gastrointestinal stromal
tumors originate in the stroma, the connective tissue that supports the foundation of various organs...
Adult stem cells from knee fat turned into cartilage, bone, fat cells
... cells within the samples known as adipose-derived stromal
cells, which under normal situations would receive...a series of enzymes and centrifuged, the separated stromal
cells were treated with a biochemical cocktail of different steroids and growth factors. "By treatin...
The Lancet Neurology press release
... addiction. Treatment of neural injury with marrow stromal
cells Michael Chopp and Yi Li (Henry Ford Health S...heir preclinical studies on the use of bone-marrow stromal
cells in the treatment of neural injury. These cells have been transplanted directly into the brain ...
Other highlights in the August 7 issue of JNCI
...s. This enzyme is also expressed in the underlying stromal
(nontumor) cells. In the August 7 issue of the J...M. D. Anderson Cancer Center in Houston found that stromal
MMP-9 expression contributes to angiogenesis and the progression of human ovarian tumors in mice. T...
Cell transplants look promising for stroke recovery
...ated with an intravenous transplant of adult human stromal
cells (mature cells from bone marrow) had signific...ays after the stroke, the rats treated with marrow stromal
cells completed the test 60 percent faster than the non-treated rats. A detailed neurological examin...
The Lancet Oncology (TLO)
...ST TARGET FOR THE 'MAGIC BULLET' Gastrointestinal stromal
tumours (GISTs) are the most recent cancer type to be targeted by the most effective new drug of recent years--imatinib mesylate. Effective treatment of GISTs has been hindered in the past by their characteristic resistance to conventional chemothera...
Imatinib shows early promise against Ewings sarcoma
... chronic myelogenous leukemia and gastrointestinal stromal
tumors. Both cancers are associated with the overactivation of a specific tyrosine kinase. In Ewing's sarcoma, overactivation of the c-kit receptor tyrosine kinase contributes to tumor growth and tumor cell proliferation. Melinda S. Merchant, M.D., ...
Iressa news backgrounder
...it has also shown to work in rare gastrointestinal stromal
tumors (GIST). Iressa was the third such targeted therapy to be FDA approved. Still these drugs, even Gleevec, are not yet the holy grail that cancer researchers seek. Most cancers employ multiple pathways to grow and survive but targeted therapies t...
Three months is too soon to judge a CML patient's response to Gleevec, researchers find
...approved, effective treatment for gastrointestinal stromal
tumors, a form of intestinal cancer that previously was often fatal. Earlier this year an editorial published in the New England Journal of Medicine dubbed Gleevec the "gold standard" treatment for CML, and the drug became the frontline therapy. Glee...
Cancer markers news backgrounder: Future of cancer diagnosis, treatment lies in tumor 'barcode'
...he gastrointestinal tract, called gastrointestinal stromal
tumor. Herceptin treats metastatic breast cancer that is driven by a gene known as HER2 that produces too much of a protein that tells cells to divide. Proteins found to be markers of these cancers also proved to be the switch that could turn the dis...
PET scans superior in revealing response to treatment for gastrointestinal stromal tumors
... been found effective in treating gastrointestinal stromal
tumors (GISTs). The result is significant, as the PET scan allows doctors to determine if the therapy regimen is working very early in the treatment process, providing information that will allow physicians and patients to decide as soon as possible ...
Hormone released by bone marrow cells may hasten recovery from brain injury
Tampa, FL (Feb. 13, 2004) -- Bone marrow stromal
cells release a blood vessel-dilating hormone foun... . "We're suggesting that transplanted bone marrow stromal
cells may hasten recovery by releasing brain natriuretic peptide and other factors that improve bloo...
University of Pittsburgh and French National Institute begin scientific collaboration
...ions to be studied include pancreatic islet cells, stromal
cells those coming from connective tissue and endothelial cells, which make up the lining of blood vessels and other internal organs. Such investigations will form the bedrock of an initiative that goes beyond conventional collaborations between in...
Fat: It isnt always bad for the heart
... both muscle and heart tissue. These cells, called stromal
cells, are immature fat cells. Their findings are ...hough he does not promote obesity, Dr. Rehman said stromal
cells have properties that can have a therapeutic effect on individuals with heart disease, chronic ...
Reprogrammable cells from fat are true adult stem cells
... the time, they termed these cells adipose-derived stromal
cells. However, as a result of the latest set of experiments, the researchers are now confident that the majority of these cells are indeed truly adult stem cells that have the potential to be reprogrammed into traveling down multiple developmental ...
Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...it has also shown to work in rare gastrointestinal stromal
tumors (GIST). Iressa was the third such targeted therapy to be FDA approved. Still these drugs, even Gleevec, are not yet the holy grail that cancer researchers seek. Most cancers employ multiple pathways to grow and survive but targeted therapi...
Presence of gene mutation tightly linked to drug effectiveness in lung cancer
...ive against certain leukemias and gastrointestinal stromal
tumors that possess specific genetic mutations, this is the first demonstration of a targeted therapy in a common adult malignancy. "One of the more striking results we found in this study was the difference in response between Japanese and American ...
Transvaginal ultrasound superior to transrectal ultrasound for staging rectal cancer in women
...e other bowel pathology including gastrointestinal stromal
tumors, inflammatory bowel disease, anorectal fistulas and fissures, and tumors and metastases in the rectovaginal pouch," said Stephanie Wilson, MD, supervising author of the study and head of the ultrasound division at the Toronto General Hospital....
Cells from fat tissue turned into functional nerve cells
...ed that within fat tissue there is a population of stromal
cells that can differentiate into different types ...e ability to reprogram these adipose-derived adult stromal
cells into fat, cartilage and bone cells. All of these cells arise from mesenchymal, or connective t...
Twice daily imatinib could improve outcome for people with specific form of gastro-intestinal cancer
... be a first-choice treatment for gastro-intestinal stromal
tumours (GIST)--is sufficient to induce a therapeutic response; a doubling of a daily dose can slightly improve progression-free survival for patients. Imatinib is approved worldwide for use in GIST, tumours which do not respond to conventional chemo...