Northwestern widens 'treatment window' for brain injury and stroke
...rbilt University, determined the three-dimensional structure of a region on the DAPK molecule that is essential to triggering programmed cell death. While initial results with the DAPK inhibitor provide a precedent for drug discovery research in acute brain injury, Watterson explained that the compound's mol...Computer design yields better, more efficient therapeutic for preventing tissue damage
...ornia, Riverside, identified the three-dimensional structure of Compstatin in solution via nuclear magnetic resonance (NMR) experiments, which he then computationally refined. The computational de novo protein design system, developed at Princeton University by Floudas and postdoctoral associate John Klepei...Amphetamine or cocaine exposure may limit brain changes that occur with life experiences
... involved in learning, can physically change brain structure and affect behavior. Now, new research in rats sho...ience. "The ability of experiences to alter brain structure is thought to be one of the primary mechanisms by which the past can influence behavior and cognitio...Chicago chemist wins national award for insights into how cells communicate
...ons, and in turn cells have ways of remodeling the structure of the matrix." Mrksich and his research team aim to figure out exactly how the cells and matrix "talk" to each other. In one test, chemists chop up a matrix protein, fix the pieces to a plate, and wash cells over the surface. Where the cells stick m...Chicago chemist wins national award for new ways to make drug candidates
...sful in treating childhood leukemia, vincristine's structure and action are nonetheless still largely unstudied...to develop reactions that might tweak its original structure for even better performance in treating leukemia. The chemist also noted, "Once you start work on a ...Antidepressant drugs may protect brain from damage due to depression
...ntidepressant drugs appears to protect a key brain structure often damaged by depression. Previous research has shown that a region of the brain involved in learning and memory, called the hippocampus, is smaller in people who have been clinically depressed than in those who never have suffered a depressive ...Radical solutions found to meet limits on junior doctors' hours
...titioners' (CSP) with a unique role. Under the new structure CSPs provide leadership, expert clinical advice and management support through a rapid response service to all areas of the hospital, 24 hours a day, seven days a week. The CSP's found that they could manage 70% of calls that traditionally would have...Is science stuck in the middle ages?
...dical scientists face in their career paths as the structure of research is changing from small-scale investigator-led research to large-scale "discovery science", such as the Human Genome Project. Discussing a recent book by the US National Academies, the editorial comments that scientific training will have ...Researchers link the plaques and tangles of Alzheimer's disease
...helps organize and stabilize the neuron's internal structure but becomes "tangled" in AD. Ever since, scientists have been trying to understand the relationship between these distinctive markers and the death of neurons that leads to the destruction of the brain and the dementia characteristic of AD. Recent ...Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
...em's T cells. As the thymus shrinks and its normal structure becomes distorted, many of the thymocytes the "immature" cells destined to become functional T cells potentially capable of destroying a variety of antigens undergo a process that weakens and kills them. Thymocytes are derived from bone marrow and...UCLA report shows disparities in children's health
...d disparities related to children's family, social structure and environment. Hardest hit are low-income and minority children, particularly Latino children, who represent 50 percent of California's youngest children. "These new CHIS findings underscore the urgent need to invest in quality preschool and health...UW-Madison receives $10 million for cancer communications research
...tion service; -- And building an interdisciplinary structure that supports discourse, understanding and modeling of cancer-communication technologies. Funding for the new center is part of a broad NCI initiative supporting research and outreach aimed at increasing knowledge about, tools for, access to, and use...First quarter prescription drug spending: Generic drugs slow upward trend
...le, clients adding a third tier to their copayment structure where members typically pay the most for non-form...mple, clients already using a three-tier copayment structure that modified copayment levels experienced a 10.8% trend. Another increasingly popular cost-manage...New type of vaccine against nicotine addiction developed by TSRI scientists
... before it gets to the brain--that's the key." The structure and design of the nicotine vaccine are described in an article that will be published in an upcoming issue of the Journal of the American Chemical Society. Research Associate Michael M. Meijler, Ph.D., who is the article's lead author, synthesized th...Laser measurements reveal biological basis of distance perception
...ese peculiar perceptions reflect the probabilistic structure of the environment with respect to the distance from us of the points on object surfaces. "Thus, for the first time, we're providing a biological basis to explain these phenomena," he said. "You see distances in this way because reflected light from ...Study suggests bipolar disorder may cause progressive brain damage
... the disorder have more prominent changes in brain structure and function. Researchers determined chemical signatures of different brain structures in these two groups using proton magnetic resonance spectroscopy. One finding focused on the level of an amino acid called N-acetylaspartate, or NAA, in the hippoc...Fulbright scholar to study nano-sized polymer magnetic complexes
...noparticle characterization, has been studying the structure and magnetism of nanoscale iron oxides since the mid-1980s. Zalich and his group have been sending the particles they create, including those coated with biocompatible/biodegradable polymeric stabilizers, to St. Pierre for characterization to furthe...Enzyme structure holds key to cocaine, heroin metabolism
...ure Structural Biology, presents the first crystal structure of the protein human carboxylesterase 1, or hCE1. ... breakdown. The researchers determined the crystal structure of the enzyme in complexes with analogues of cocaine and heroin. They found the enzyme could bind to...Brookhaven spotlights: News from the March 2003 American Chemical Society Meeting
...otate and vibrate, providing new insights into the structure of greenhouse gases and the inner workings of combustion reactions. The method, called two-layer Lanczos algorithm, is a modified version of a well-known method introduced in 1956, and has been successfully applied to methane, formaldehyde and rare-g......l various shapes and has created a less bulky host structure that might provide a means for drug delivery withi...f scientists, the non-covalent bonds that form the structure can be reversed to release the contents. Feihe Huang, a doctoral student at Virginia Tech, will pres...