Adrenaline packs a powerful punch in the use of antidepressants
... reuptake inhibitors (which work by increasing the synaptic activty of adrenaline in the brain); and selective serotonin reuptake inhibitors (which elicit their effects by increasing the activity of serotnin in the brain). Previously, it was believed that SSRIs whose over-the-counter names include Prozac, Z...How a dietary supplement can protect against Alzheimer's disease
...D can act synergistically to quantitatively reduce synaptic proteins, specifically, dendritic scaffold proteins, that are critical for cognition as evidenced by memory deficits observed in the Morris water maze paradigm," wrote the researchers. "The results show a dramatic impact of diet on the expression of ...Tuberculosis drug combined with virtual reality therapy is effective in treating fear of heights
...nces. Because it was known that DCS improves NMDA synaptic transmission and we found it improved extinction in rats, we hoped to facilitate the effects of cognitive behavioral therapy by combining DCS with virtual reality therapy in humans. Our results demonstrate that this combination is effective, and tha...New compounds effective against Alzheimer's disease onset and progression
...thology, including neuroinflammation, neuronal and synaptic degeneration and amyloid disposition, often called...neuron loss, restoration towards control levels of synaptic dysfunction biomarkers in the hippocampus and diminished amyloid plaque deposition. Consistent with...News tips from the Journal of Neuroscience
...-derived neurotrophic factor (BDNF) contributes to synaptic plasticity and memory formation by several mechani... suggest that BDNF not only influences fast-acting synaptic mechansims, but also shapes circuit development in a way that can be seen at the macroscopic level. ...Brain's nicotine receptors also target for anti-depressants
...e past several decades has been drugs that inhibit synaptic reuptake of monoamine neurotransmitters. Recent evidence indicates other neurotransmitter systems might play a role in the mechanism of action of antidepressants, Picciotto said. In this study in mice, she and her colleagues tested the action of anti...Marine snail study gives insights into human brain
...ook like there is any difference on a molecular or synaptic level. "When this animal learns," Glanzman said...alled AMPA glutamate receptors, which mediate most synaptic transmission in the brain. Glanzman is studying the role of AMPA receptors in learning. ...New theory chalenges current view of how brain stores long-term memory
...t theory is that he and Rekart do not believe that synaptic modification is brought about by recently synthesi...leads to a post-synthesis (or, post-translational) synaptic protein modification that results in changes to the shape, activity and/or location of existing syna...Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
...t Fragile X patients have a tendency to break down synaptic connections (sites used for neuron to neuron communication) more readily than the general population. This breakdown is due to an increased activity in the metabotropic glutamate receptor (mGluR), which is located on the surface of neurons, including...