Tag: "tamoxifen" at medical news

New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report

...the risk ofendometrial cancer in women. Although tamoxifen was recently reported to reduce the risk of breast...ancer. Of the 13,388 women who participated inthe tamoxifen study, 33 of those who received the drug developed endometrialcancer, compared to 14 of the women as...

New Data Show Evista Reduces Spinal Fractures

...ease to directly compare the benefits and risks of tamoxifen and Evistatherapies. As with most drugs, Evista therapy is associated with some side effects, themajority of which were reported as mild. The most commonly reported side effectsin this clinical trial were hot flashes (5.4 percent incidence in the pla...

Novel Therapy Significantly Reduces Spinal Fractures In Postmenopausal WomenWith Two Years Of Therapy

...olesterol levels. However, raloxifene differs from tamoxifen and estrogen because it does notstimulate the lining of the uterus, Cummings said. He added that compared to estrogen, raloxifene reduces the risk of breastcancer, and does not cause problems of uterine bleeding and breast tenderness,which may result...

Better Survival For Women With Breast Cancer -New Evidence On Chemotherapy

...ting these. One is hormonal therapy: forexample, tamoxifen can be used to block hormone receptors on the canc...fined to herbreast." The study shows that, even if tamoxifen is to be given, chemotherapy producesadditional benefit. Moreover, chemotherapy improves survival a...

Signal Pharmaceuticals Announces Positive Results In Preclinical Study Of Novel Drug Leads For Treatment Of Osteoporosis

...ted superior safety, whencompared with raloxifene, tamoxifen and estrogen, with regard to potentialcancer risks in reproductive tissues. These drugs, if successfully developed,would provide clinicians with an alternative, non-estrogen treatment forosteoporosis that also would minimize some of the adverse effec...

Osteoporosis Drug Evista (Raloxifene) Cuts Newly Diagnosed, Invasive Breast Cancer Risk By More Than 60 Percent

...t cancer prevention trial comparing the ability of tamoxifen and raloxifeneto prevent breast cancer. The STAR trial will determine the safety andeffectiveness of raloxifene in reducing the occurrence of breast cancer in womenat high risk. Enrollment for the trial is expected to begin in 1999. Raloxifen...

Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs

...co have discoveredthe molecular mechanism by which tamoxifen blocks the effects of estrogen, aprocess that has ...how estrogens turn on genes and show precisely how tamoxifen blocks this process," said first-author Andrew Shiau, agraduate student in biochemistry & biophy...

Vanderbilt Cancer Center Discovery May Help Overcome Resistance To Anti-Breast Cancer Drug

...ome a major obstacle in treating breast cancerwith tamoxifen -- the resistance that breast tumor cells commonly...tain growth factor, calledTGF-beta, contributes to tamoxifen resistance. They also demonstrate that theimmune system's "natural killer" activity is important for...

Study Finds Lymph Node Surgery Unnecessary For Many Breast Cancer Patients

...s. Physicians alsonow routinely prescribe the drug tamoxifen to treat tumors with estrogenreceptors, regardless of node status. These methods are quite different thanthose available when axillary lymph node dissection studies initially tookplace, Parmigiani said. The biggest benefit of axillary node dissectio...

UCSF study finds that an osteoporosis prevention drug reduces the risk of breast cancer by 76 percent in postmenopausal women

...is or pulmonary embolusshould not take raloxifene, tamoxifen or estrogen. Further, more women in the raloxifene group (1.2 percent) reported a new orworsening condition of diabetes compared to those in the placebo group. However,the diabetic women's sugar levels did not increase nor did their need fortreatment...

Duke/Novalon researchers identify potential mechanism behind tamoxifen resistance in breast cancers

...entified a likely reason why the breast cancerdrug tamoxifen stops working in women who use it for more than fi...or and blocking estrogen from docking to it.Hence, tamoxifen has been called an "anti-estrogen." Later, however, tamoxifenbegins to lose its effectiveness, and ...

Tamoxifen found to increase risk of endometrial cancer

Women whose breast cancer is treated with tamoxifen face a heightened risk forendometrial cancer, with...ost frequent gynecologic cancer in women. "Because tamoxifen is a critical therapeutic option for breast cancer patients,we need to understand its other effects ...

Vitamin A compound may help protect younger women against breast and ovarian cancers

... fenretinide (200 mg) combined daily with low-dose tamoxifen (5 mg) on premenopausal women who are at increased...in situ cancer. In animal studies, fenretinide and tamoxifen -- the estrogen-receptor modulator which appears to dramatically block the development of estrogen-r...

Research study maps formation process of certain type of breast cancer

...n to grow and proliferate, conventional drugs like tamoxifen that block estrogen from acting on breast cells are generally ineffective against ER-negative tumors. About 30 percent of all breast cancers are ER-negative. "The discovery of the steps involved in the creation of ER-negative breast cancer cells mean...

Estrogen has antitumor activity in hormone therapy-resistant breast tumors

...tumors that have developed resistance to the drugs tamoxifen and raloxifene. Tamoxifen is a selective estrogen...rs and prevent recurrence of the disease. However, tamoxifen often loses effectiveness over time and can subsequently stimulate breast cancer growth. New endocri...

University of Pittsburgh-led study confirms that Raloxifene protects post-menopausal women from invasive breast cancer

...isk of this disease. As in the case of raloxifene, tamoxifen produced its greatest risk reduction in women with...nd reduce vertebral fractures. Previous studies of tamoxifen also have shown its ability to increase bone density and reduce fractures, but this effect was not s...

PET scans identify breast-cancer patients who will respond to hormone therapy

...h woman in the study received two PET scans before tamoxifen therapy began and two more seven to 10 days after ...-receptor positive breast cancer will benefit from tamoxifen therapy. And that should help improve the quality of life for these patients....

Raloxifene following tamoxifen may offer no more reduction in breast cancer risk

...e suggests that taking raloxifene after 5 years of tamoxifen therapy may not further prevent the growth of brea...apy with the selective estrogen receptor modulator tamoxifen helps some women with early-stage breast cancer reduce their risk of recurrence. But some studies ha...

Raloxifene after tamoxifen not beneficial

Taking raloxifene after five years of tamoxifen therapy does not prevent the recurrence of breast ...ed the effects on tumor growth of raloxifene after tamoxifen treatment in mouse models of breast and endometrial cancers. They found that, after exposing breas...

First IBIS results show tamoxifen reduces breast cancer in healthy high-risk women

... from the long-awaited IBIS trial into the use of tamoxifen to prevent breast cancer in healthy women at high ...s have been mixed. In addition, nine trials using tamoxifen for treatment of breast cancer patients and who were therefore at high risk of developing a second c...

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