Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
... of drugs that bypass the leptin brain circuit and target the fat cell itself. Duke researchers say their study, reported today in the journal Nature,is the first to demonstrate how leptin initiates the burning of stored fat, a process thathas been postulated but never proven. In fact, their study shows t...Chemists Develop Probe To Detect Changes In Imaging Agents Inside Body
...ch as technetiumwith a ligand or compound that can target the tissue or organ ofinterest. For example, a common application is a heart imagingagent which can detect blockages in blood flow following a heartattack. This information is important to doctors planning follow-up therapy and rehabilitation. "Docto...Discovery Hints At Multitude Of New Targets For Drugs
...gistsseek new drugs to modulate them. "To target drugs to one body tissue, pharmacologists have traditionallylooked for subtypes of a receptor unique to that tissue," he said. "They could then design compounds that would select one or anothersubtype. But if there was only one kind of receptor, they...Alzheimer's disease center seeks patients for new drug studies
...played by genes. The new generation of medications target various sections of the brain that degenerate during the course of the disease. Alzheimer's disease affects approximately 4 million Americans. The UT Southwestern clinic currently sees about 300 patients. For more information about the new drug stu......ive development of AIDS means that doctors may now target these babies for early, powerful therapies, report Emory University researchers in this week's New England Journal of Medicine . Infants who test positive for HIV can generally be divided into two groups: those in whom AIDS symptoms develop quickly...Guidelines Offer Ways To Curb Antibiotic-Resistant Infections
...Hoffmann said, but the new N.C. statewide measures target facilities such as nursing homes and doctors' offices. “The approach we took is very reasonable,” Hoffmann said. “It wouldn't make any sense, for example, to treat a patient at home the same way the CDC recommends treating a patient ...Intralase Will Develop Laser Systems For Eye Surgery
... other vision deficiencies. The company will then target glaucoma, cataract and dermatological surgery. "IntraLase demonstrates the U-M's many strengths as a research university, especially its capacity to integrate new technology with basic research and turn it into a life-enhancing medical interven...Researchers Study 'Natural' Screen For Cancer
...dynamic-treatment " once again,using light rays to target the cells can help kill the disease. An orangelight forces hypericin to release oxygen "singlets" and decompose cancerouscells. A second study involves the use of a "diffused spectroscope" to studymelanoma, or skin cancer. Researchers devel...Chemist Turns To Self-Assembly To Create New Drugs
...t match elbows out all theothers to latch onto the target molecule. "With our technique, we try to find...ers that the new method works forfinding drugs to target and bind to double- stranded DNA made upof a single repeating base. They're now examining whether th...Tighter Chemical Binding = Better Meds
...-dimensional picture of a drugbound to its protein target -- usually generated through a process calledX-ray crystallography -- then modifies the compound and computes how thechanges affect the drug's binding ability. The 3-D structures of hundredsof key human proteins have been solved in recent years, man......pted to design more effective drugs toindividually target these various molecules. "Drug candidates need to be evaluated in the context of a particularpain syndrome," Basbaum says. "Pain relief often may depend on the particularmedical condition and on the quality and intensity of the pain." ......I and DNAin order to understand and more precisely target the key interactions betweencamptothecin-Topo I/DNA. BioNumerik used this information to guide andcomplement the discovery and optimization of novel compounds for laboratorysynthesis and preclinical testing. In a presentation titled "BNP7787: Admi...Successful Cancer Therapy May Doom Later Treatments To Failure
...st also think about aiming their drugs at a moving target -- blood vessel pores that change in size over the course of treatment. Yet drug companies have been taking a one-size-fits-all approach, Jain says. In the area of gene therapy, the trend has been to design bigger and more impressive molecules. ...PITT Researchers Demonstrate Human Brain's Natural Mechanism For Guarding Against Errors
...ing a series of numbers and looking fora specified target -- an "X" immediately following an "A" -- and pres...s. A button on the left was pressed each time the target appeared andone on the right for every other combination. Dr. Carter and his colleaguesnoted a tran...New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
... binding to structures called receptors in various target tissuecells, which then stimulate different responses. The hormone can cause tissuegrowth in a woman's breasts and uterine lining, and over time, may increase herrisk of breast or endometrial cancer. At the same time, however, estrogen has been prov...Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
... Dr.Marmorstein, "the CDK4 protein is an excellent target for anti-cancertherapies." His laboratory's findings on the structural properties of theP16INK4 protein are expected to provide a framework for the design of P16INK4imitations that can be used in the treatment of cancers caused by abnormal CDK4activ...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...ent for obesity. Instead, drug therapy may have to target the multiplesystems that control weight. Drs. Stephen Woods and Randy J. Seeley, formerly of the University ofWashington and now of the University of Cincinnati Medical Center, and Drs.Daniel Porte, Jr. and Michael W. Schwartz of the Universi...New Treatment Targets Most Malignant Brain Tumors
...ia, firm Cyclotron Inc., Zalutskydeveloped a metal target that could be inserted directly into the Duke medicalcenter cyclotron. When bombarded by the cyclotron beam, the bismuth-coated plateefficiently generated large amounts of the astatine isotope, which could berapidly isolated. "We get a yield ...Abstinence Reduces HIV For High-Risk Women - Even Those Who Relapse - Study Shows
...of three different kinds of programs:programs that target (1) women who are intravenous drug users (IDUs); (2) womenwho are IDUs and women who have high risk sexual partners; and (3) all women. These programs screen women to determine whether they carry the AIDS virus andoffer counseling on ways to reduce t......ation's go-ahead in early June. Futuretrials could target other portions of the molecules that the new crystalstructure reveals to be crucial to infection. The crystal structure also reveals potential new drug targets. "At theinterface of the gp120/CD4 receptor is a large cavity that is a drug desi...