Study finds new designer drug is potent treatment for chronic myelogenous leukemia
...armaceuticals in Basel, Switzerland have created a targeted therapy for chronic myelogenous leukemia (CML) that may ultimately be more effective than Gleevec, the current frontline treatment. The researchers report in the February issue of Cancer Cell that the new compound, AMN107, is about 20 times more pote...Mayo Clinic identifies key cellular process in prostate and other cancers
...ressors for destruction. FOXO1 is suited to being targeted for destruction via the ubiquitin pathway. The researchers noted that high levels of Skp2 were associated with low levels of FOXO1 in many human cancer cells, including prostate cancer -- and then combined the lines of evidence outlined above to des...Dialogue & personal example work best for parents in drug talks with teens
...mmunicate on a regular basis about drugs, then the targeted drug talk becomes more helpful, especially before ...ric of their everyday lives as opposed to the more targeted one-shot 'drug talks.' " For parents, it is critical to hone both listening and observation skills ...Routine HIV screening should be expanded, study finds
... published in the scientific literature. The model targeted patients who were unaware of their HIV status when they entered the health care system, whether at a hospital, clinic, routine medical or emergency room visit. The model then calculated the incremental costs and benefits across the lifetime of typica...Early HIV screening prolongs life and is affordable, Stanford study shows
...disagreement among experts over whether blanket or targeted screening is more effective.) The majority of HIV patients are diagnosed only after exhibiting symptoms that prompt testing: the CDC reports that more than 40 percent of patients don't learn of their infection until very late in the game. "We know fr...Elderly people cared for by spouse are at greater risk for abuse, Pitt researchers find
...ened and, if troublesome signs are found, possibly targeted for intervention. Prior research, some conducted at Pitt, has shown that being a caregiver causes negative health effects. "Caregiving is stressful, and it breaks down the people that are providing the care--they wear down," said Beach. "This study s...Rice's CNST awards Smalley/Curl funds for innovation
...nd for Innovation, Drezek and Hafner will evaluate targeted nanorods as molecular probes for reflectance confo...ly, he hopes to engineer these patchy capsules for targeted drug delivery and other advanced encapsulation applications."I am thrilled to receive this honor in ...Aetiology of congenital heart disease explained
...to the foetus during pregnancy. The antibodies are targeted against endogenous proteins and cause the inflammation and calcification of the foetal cardiac conduction system. One in three of such cases are fatal to the foetus, and approximately 70 per cent of the babies born alive require life-long pacemaker t...UCLA brain scientists crack mystery of how alcohol causes intoxication
... variation alters GABA receptors -- specific sites targeted by chemicals from the brain cells -- making them more responsive to very low levels of alcohol. Alcohol enhances the GABA receptors' influence on brain cells, slowing the cells' activity and ability to communicate. IMPACT: The fact that the gene m...Mayo Clinic researchers create 'obedient virus'; First step to use measles virus against cancer
... it's meant to go, and it destroys the tumors in a targeted way,'' says Dr. Russell. Background Biology Natural viruses are cellular parasites. To reproduce more viruses, they need to bind to a partner on their target cell, fuse membranes to enter the target cell and then take over the cellular machinery. W...Cholesterol under-treated in high-risk women in managed care study
.... "These findings suggest that therapies should be targeted to the specific cholesterol abnormalities in each woman, so that optimal levels of both the good and the bad cholesterol can be attained," Mosca said. "The reason for under-treating high cholesterol in women remains uncertain; however, the need to b...New way to block pox shows promise in lab study
... viral infections on its head. By developing drugs targeted to the unchanging chemical pathways used in normal cell processes and co-opted by viruses, the investigators say it might be possible to battle acute viral infections in a way that prevents the virus from mutating its way around a drug attack. "The t...Women's heart risk underestimated by doctors, resulting in less preventive care than in men
...nes. In particular, educational efforts should be targeted to assist physicians in heart disease risk assessm...f this study. Education and support needs to be targeted to women as well. "Lifestyle is the fundamental method to prevent heart disease," Mosca said. "The...Treatment for brain tumor does not always follow recommendations
...n MRI. As oncology takes on increasingly specific, targeted approaches, it is inappropriate to continue rolling out new therapies indiscriminately and often conclude that they are not effective in 'malignant gliomas,' a molecularly heterogeneous group of tumors lumped together based on light microscopy. Some ...Disaster management: Better management of hospital resources and staff is the answer
...alcareprofessionals should be offered better, more targeted disaster medicaltrainingthat includes exercises in realistic disaster situation simulations,emphasizinghospital response. In addition, web-based knowledge collections should beavailable to health workers for last minute, quick and easy querying at th...Rice scientist recognized as pioneer in tissue engineering
...ping new fumaric acid-based polymeric carriers for targeted delivery of signaling molecules including peptides, proteins, and plasmid DNA. A pioneer in the field of tissue engineering, Mikos is a founding editor of the journal Tissue Engineering and member of the editorial boards of the journals Biomaterials,...New leukemia drug shows promise in overriding all Gleevec resistance
... to inhibit the actions of BCR-ABL. To do so, they targeted parts of the BCR-ABL protein that didn't appear to be mutating and adapting to Gleevec. "We developed ON012380, a compound that specifically inhibits BCR-ABL by blocking a different site in the protein, which is essential for its activity. As a res...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...rapies to the settings in which they are initially targeted and maximally cost-effective." Carolanne Dai of the University of Chicago was the lead author of the paper. The research was supported by the MacLean Center for Clinical Medical Ethics at the University of Chicago, the National Institute of Aging, a...The Lancet calls for the creation of a world institute for risk evaluation
...be quantified and prioritised, and issues would be targeted prospectively rather than responded to retrospectively. WIRE's work would take place in open forums. Its advisers would represent a wide range of disciplines." "WIRE would not--it could not--make judgments about the economic benefits, political feasi...USC/Norris oncologists test new front-line therapy for pancreatic cancer
...e five years after diagnosis." But Lenz hopes that targeted medications such as BAY43-9006 will become part of...fast-growing cells (even some non-cancerous ones), targeted drugs such as BAY 43-9006 focus exclusively on a few targets specific to cancer cells. In this case,...