Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...els through the bloodstream to the brain, where it targets clustersof neurons in the hypothalamus, a brain structure that regulates food intake and metabolism,among other functions. When leptin binds with receptors on these neurons, it sends asignal to the body to decrease food intake. In addition, the Duke ...New Drug For Parkinson's Disease Proves Effective, Study Finds
...Dr. Kieburtz says that's probably because the drug targets the specific dopamine receptor involved in Parkinson's disease more precisely. "Pramipexole dihydrochloride had a very good tolerability and safety profile," Dr. Kieburtz says. "We thought this drug would be effective, but we were pleasantlysurp...Targeted Protein Toxin Effective Against Persistent Brain Tumors
...phtheria toxin to a protein calledtransferrin that targets rapidly growing cells such as tumor cells. Nine ofthe 15 patients who were evaluated after this treatment had reductions in tumorsize, and the tumor disappeared completely in two patients. While these resultsare promising, much more work remains b..."Powerful New Tool" For AIDS Is Reported In Science
...he treatment of serious diseases. Initial disease targets for this technology include AIDS, cancer, cardiovascular disease and osteoporosis. The second program, developed in part from research efforts conducted at the United States Department of Energy -- Ames Laboratories' Institute for Physical Research a...Snipping Inflammation In The Bud; New Agents May Provide Relief
...molecules,for example, can slip off their cellular targets and the L-selectin proteins cancome back into play. However, the new class of agents developed by Kiessling and colleagues Eva J.Gordon and William J. Sanders, dubbed "neoglycopolymers," also cause cells toshed the surface protein L-selectin and th...Drug Is First In Decade To Show Promise Treating Generalized Anxiety Disorder
...han othercommonly used anti-depressants because it targets two neurotransmitter systems,serotonin and norepinephrine, rather than one. Serotonin has been shown toelevate mood and sense of well-being, while norepinephrine appears to boostenergy and social functioning, he said. Finding effective trea...Is Ritalin As Effective--And As Harmless--As It Could Be?
... d-threoenantiomer bound precisely to the dopamine targets in the brain, while thebinding of l-threo was mostly non-specific. What's more, Ding says, the l-threo enantiomer may have some unwanted influenceon the active enantiomer or may contribute unwanted side-effects, althoughlong-term human studies would ...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...duals. "Interventions directed at multiple targets in the energy homeostasissystem might be necessary to achieve and maintain weight loss."......te receptors could provide importantpharmaceutical targets in the treatment of psychiatric disorders associated withincreased or decreased glutamate-mediated signaling between neurons," Moghaddamsaid. She cautioned, however, that the drug might not have the same effect inpeople, and that PCP-induced symptom...University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence
...y. Used to treat other cancer types, immunotherapy targets immune cells to attack adisease. "We're going to educate the immune system in the lab," Jordan said. "We'veinvented a new technology to genetically change the tumor cell." The researchers plan to extract tumor cells from a patient, culture them, and...... genes and theirproteins, which serve as molecular targets for drugs because they controlbiological processes that often lead to disease. "With this approach, we start with a chemical compound called a platformthat locks onto a specific molecular target. We change the platformincrementally to quick...Scientists Discover How Aspirin Reduces Inflammation
... one of the critical cellular proteins thataspirin targets to inhibit inflammation is a kinase that activates the NF-kBpathway. Since NF-kB is a critical inducer of cellular genes involved in theinflammatory process, aspirin inhibition of this kinase prevents NF-kBactivation and suppresses inflammation," Gay...New Drug Boosts The Power Of Traditional Cancer Therapies, UF Animal Studies Show
...ndirectly fight tumors, combretastatin A-4 prodrug targets the blood vessels that sprout up to nourish cancerous growths. The idea of battling tumors by attacking their life support system has long been championed by Judah Folkman, a physician and cancer researcher at Children's Hospital in Boston who has re......ways incells and to identify proprietary molecular targets that activate or deactivategenes and result in disease. Signal is advancing the application of genomicsbeyond identifying and elucidating the functions of genes to designing novelclasses of disease-modifying drugs that selectively regulate the activ...Promising Bone Cancer Therapy Advances To Next Level
... the Brookhaven researchers found that thetin-117m targets only the bone, sparing the marrow and soft tissue, but stilldelivers a highly localized dose of electrons to the tumors to ease pain withoutsedation. Because it also emits a weak gamma ray, it allowed physicians to usesophisticated imaging equipment...T-Cell Memory Finding May Provide Key To Cancer, AIDS Vaccines
...on-Rickardt. "They remembered and went after their targets as soon as theywere exposed to them again. Although mice with normal immune systems take two orthree days to mount an immune response, these memory T cells respondedimmediately." The finding is particularly encouraging for those interested in vaccine...NIA Launches National Study To Treat Mild Cognitive Impairment
...linical stages of AD. The Memory Impairment Study targets people between the ages of 55 and 90. Thoseinterested in participating in the clinical trial should have a memorycomplaint, exhibit memory impairment in testing--but be able to perform everydayactivities normally--and should not have a clinical diag...Neurobiologists Show How The Brain Processes Signals From Pheromones
...pheromone receptor project their axons to multiple targets in the accessoryolfactory bulb, called glomeruli. There are about 15 glomeruli in all, comparedto only two in the main olfactory bulb. Second, the positions of the glomeruliin the accessory olfactory bulb are variable, whereas in the main olfactory ......heseparts of the lung, while smoking damage in men targets the larger, morecentrally located airways. The take-home lesson from this study is that methods of lung-cancer screening inhigh risk populations must take gender into consideration, and perhaps,different screening procedures and criteria will have to......similar diary techniques in adolescents may reveal targets for early preventiveinterventions." The findings suggest that smoking prevention and cessation programsmight be more successful if they had different approaches for males and females,and if they targeted people according to their persona...