Other highlights in the December 3 issue of JNCI
...lorectum, breast, and prostate that could serve as targets for chemoprevention. They also examine epigenetic strategies to preventing cancer, including the use of DNA methyltransferase inhibitors and the combined use of epigenetic drugs with agents that target reactivated genes. The authors conclude that, "p...Beta-blocker or calcium antagonist-based therapies equally effective in treating hypertension
.... "In conclusion, our results indicate that lower targets for blood pressure control can be achieved in most hypertensive patients with CAD using a multidrug strategy that includes administration of angiotensin-converting enzyme (ACE) inhibitors to patients with heart failure, diabetes, or renal impairment....UCLA studies experimental cancer drug
...will test a drug called CCI779, which they believe targets mTOR. "We discovered that tumors missing PTEN seem...nter in Philadelphia, Sawyers said. Because CCI779 targets only what is broken in the cancer cell, it is expected to cause very few side effects, Sawyers said....Researchers use crippled poliovirus to attack brain cancer
... "We have a virus that naturally targets brain cells, but we have replaced the genetic coding element that makes the virus so dangerous," said Gromeier. "The virus has lost its ability to grow in normal neurons." Tests in mice and in non-human primates have confirmed that...Brain area identified that weighs rewards
... By studying how monkeys choose to look at lighted targets for juice rewards, neurobiologists have identified a still-mysterious region of the cerebral cortex as an area that judges the value of rewards, and adjusts that value as circumstances change. The finding adds a significant piece to the puzzle of how...Three months is too soon to judge a CML patient's response to Gleevec, researchers find
... overproduces cancerous white blood cells. Gleevec targets the cancer cells while leaving normal cells unharmed, producing little or no side effects. The blood counts of virtually all CML patients treated with the drug have returned to normal. For this study, researchers sought to determine how long Gleev...Drug prolongs lives of chronic lymphocytic leukemia patients
...rs. Rituximab is a monoclonal antibody that targets a protein known as CD20 found on immune cells known as B lymphocytes. Scientists believe rituximab kills malignant CLL cells by causing programmed cell death, or apoptosis. This randomized phase 2 study included 104 previously untreated CLL p...Cancers' love-hate relationship with proteins offers new treatment window
...at shock protein (Hsp) 70.1 and 70.3, as potential targets for gene therapy that could increase cancer cells' vulnerability to treatments. "This is the first time we've linked these proteins to the cancer cell's response to ionizing radiation," says Tej Pandita, Ph.D., assistant professor of radiation onc......incompetent. The first study shows how performance targets encourage gaming and "creative accounting" of data. The authors describe how to manipulate hospital waiting times and suggests that position in league tables may also be improved by various gaming strategies to reduce hospital death rates. On a seri...Patients recovering from depression with talk therapy show a 'distinct' pattern of brain changes
...ll course of therapy. Investigators found that CBT targets many of the same limbic and cortical regions affected by drug therapy, but in 'different directions'. With drug therapy, metabolism (blood flow) decreases in the limbic area and increases in the cortical area. With CBT, Mayberg and colleagues identif...Air pollution may significantly worsen respiratory allergies in individuals with genetic risk
...s such as heart attacks. Such research may suggest targets for drug interventions....Successful, rapid protein crystallization possible with technique developed by UCSD researcher
...DXMS to help guide our design efforts with protein targets that do not crystallize well," said another of the...o date, we have found that 20 to 40 percent of the targets that are amenable to crystallography could potentially benefit from the DXMS analysis. We think tha...One dose of 'designer' gene therapy may target specific body area
...e vascular endothelial cells (ECs).The new therapy targets vascular endothelial cells, which line the inside ...d in cardiovascular abnormalities, are appropriate targets for gene therapy," Baker said. Baker said that AAV is important because it has the potential for lon...Most people with diabetes do not meet treatment goals
...reover, the percentage of people who achieve these targets has changed little in the last decade, according to a study published in the January 21, 2004, issue of the Journal of the American Medical Association. "More diabetes patients are taking medication to control their blood pressure and cholesterol, ...Risk of death in car crashes reduced if all occupants wear seat belts
...ts who made up the cohort pairs are referred to as targets in this article to distinguish them from other occ...ere 61,834 cars with two front-seat targets; 7,969 targets were in front of a left rear occupant and 10,785 were in front of a right rear occupant. There were...The physics of films, butterflies, banknotes and rainbows
...) Trouble as Hubble heads for the dust (p. 5) US targets the Moon and Mars (p. 6) Japan approves neutrino project (p. 7) Attosecond lasers come of age (p. 10) Detecting the colours of darkness (p. 20) A reading and writing revolution (p. 18) Maxwell's equations and earthquakes (p. 21) Lord Kelvin, sc...A little stress may go a long way toward boosting skin's immunity
...could possibly help scientists develop therapeutic targets for such diseases." Learning how the body mobilizes an immune response during stress could also give researchers insight into creating more effective vaccines. "The whole point of vaccination is to generate more memory cells," Dhabhar said. "The way ...UC San Diego scientists unveil pilot project for automated monitoring of animal behavior
...e already been deployed at potential bio-terrorism targets and chemical research facilities to warn operators of gas or other leaks. Instead of requiring that a human watch each animal in each cage for early warning signs, the Smart Vivarium technology would automate the process, resulting in reduced need fo...AACR hosts 95th Annual Meeting
...ian cancer Tobacco-induced genetic changes may be targets for intervention, prevention When: March 2731, 2004 Where: Orange County Convention Center Orlando, Fla. ...ESC in partnership with EU to strive for European consensus on CVD treatment and prevention
...rdiovascular disease prevention outlining specific targets that populations should be set in terms of blood pressure, cholesterol levels and stopping smoking. Since then, we have been keen to continue the momentum and dialogue with the EU and hope that we will continue to do so during the future Presidencie...