Jefferson Scientists Show Tumor Characteristics May Help Explain Tumor Biology And Prognosis
...e could provideinformation allowing us to identify targets for new therapeutic approaches tocolorectal cancer."...Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
...nt known as calicheamicin, theantibody selectively targets leukemic blast cells, while sparing cells that areresponsible for replenishing normal blood cells once the leukemia is eradicated. Promising results continue to emerge from a pivotal Phase II trial in the U.S.,which involves patients who experienced ...Success of plasma centers could hurt Red Cross, study finds
...ery two months. College students have been targets of the paid donor recruitingstrategies since the 1970s, Anderson says, driven in part by for-profitagencies' desire to improve the quality of the blood plasma supply. A largepercentage of paid donors historically have come from the underclass andhome...Aspirin's role in colon cancer prevention focus of $5 million grant
... called cyclooxygenase-2 (COX2), one of theprimary targets for aspirin and NSAIDs. DuBois and his team have found that COX2is elevated in colon cancer and have demonstrated in animals that colon tumorswill shrink dramatically if treated with drugs that inhibit COX2 activity. Other researchers in ......e disease will lead to the discovery ofbetter drug targets and the development of more effective drugs." Haines helped Glaxo Wellcome develop its plan for setting up Clinical GeneticsNetworks to search for the genetic basis of common diseases. "I have known and collaborated with Jonathan Haines for two decad...New laser treatment allows patients to swallow and breath easier
...the laser is in position, the energy fromthe laser targets the light-sensitized tumor. "Previously, lasers were very technique sensitive," Warren said. "Surgeonswould have to be very precise when burning tumors to avoid damage to surrounding normal tissue." However, surgeons can place the new laser adjacen...First NIH clinical trial for interstitial cystitis begins
...tments and studies suggest that each drug uniquely targets differentaspects of IC. In some patients, ElmironR reinforces the bladder lining,usually a barrier to urine's toxicity. ElmironR is the only oral drug approvedby the Food and Drug Administration for IC. AtaraxR is an antihistamine thatreduces the ...Differences in human brain chemistry may account for different responses to stimulants
...erable to abusing drugs and provides new potential targets forboth prevention and treatment efforts." In the study, Dr. Nora Volkow and her colleagues at Brookhaven NationalLaboratory in Upton, New York, and at the State University of New York at StonyBrook used a brain imaging technique called positron emis...UNC AIDS vaccine researchers awarded $12 million federal grant
...re immune." According to Johnston, the VRP vaccine targets cells in lymph nodes, thecritical tissue of the immune system. "The vector will produce the immunizingprotein in the heart of the immune system. And we think some of itseffectiveness derives from that biological feature," Johnston says. In their most...OHSU researchers test medication that targets fever without side effects
...t both forms of the enzyme, rofecoxib specifically targets COX-2.That means COX-1 is left to support normal functions in the body while the newdrug inhibits fever production by the COX-2 enzyme. In the past, theinterruptions of COX-1 functions have been known to cause kidney and stomachproblems for some pati......H (luteinizinghormone-release hormone) analog that targets only cells with LH-RH receptors onthem. This makes the compound specific to cancers of the ovary, breast, cervixand prostate, and possibly others as well. AN-152, now in animal trials, first was synthesized by Andrew V.Schally, Ph.D., M.D.h.c...Antibody solution may prevent adhesions after surgery
...pps Institute, La Jolla, California. This antibody targets thealpha-v/beta-3 integrin, which has been shown to be important in new bloodvessel formation and tumor cell invasion. Cheresh, a pioneer in the field ofintegrins, discovered these integrins and produced the antibody, the humanizedversion known as Vi...UNC studying new drug against ovarian and endometrial cancers
...dometrial and ovariancancers the drug specifically targets estrogen cell receptor sites in uterineand ovarian tissue. In doing so, this "designer estrogen" would block estrogenuptake of ovarian and endometrial tumors, thus inhibiting their growth. At the same time, the drug may offer additional benef...Researchers find elevated cholesterol is risk factor for preeclampsia
...at specific lipids areinvolved, which will give us targets for prevention. Until then, we can saythat pregnant women who have elevated cholesterol before their pregnancies andwho have other risk factors - like first pregnancy, diabetes, and preexistinghypertension - should be followed more closely by their ...... viruses use to inactivate PKR could be attractive targets fordrugs that would kill infected cells and stop persistent viral infections. Aprotein produced by Hepatitis C may be the first example. A screen could be developed to identify naturally occurring antiviral agents.The system would identify virus-infe...Pathway may provide target for treating chronic pain
...psesvia the AMPA receptor, providing two potential targets for therapy. "I think this study really su...ly are not painful," Zhuo said. "The more of those targets we canidentify, the greater the odds we can find medicines to help patients who arenot helped by tra...Hopkins gene therapy trial is first to activate entire human immune system against prostate cancer
...before been seen," he says. All prostate cells are targets for this type of gene therapy because anyprostate cell that survives surgery has the potential to turn malignant andbecome lethal to the patient. However, since the prostate is not a vital organ,the researchers say destruction of the prostate cells ...UCSF receives grant to fight cervical cancer
...nity Health (REACH 2010)"- a national project that targets six healthpriority areas with the goal of eliminating, by the year 2010, disparities inhealth status experienced by racial and ethnic minority populations. "Vietnamese-American women have the highest cervical cancer incidence rate ofany ethnic group ...Scientists identify new pathway of antidepressant action
...zymes that synthesize neurosteroids can make prime targets for mood-regulating drugs. "We're interested in finding compounds that may directly affect these enzymes in the brain, and thus regulate mood disorders with minimal side effects," she said. The research was supported by the National Institutes of Hea...... used in the study, is a protease inhibitor, which targets the enzyme protease. Efavirenz is taken only once a day, in contrast to other drugs in the combination therapy, which require 3 to 4 doses daily. A more convenient regimen would make it easier for children to comply with the treatment, and said Dr...