Researchers build on discovery of potent potential antibiotic
...ey enzyme in Gram negative bacteria. The compound targets the enzyme KDO 8-P synthase, which plays a vital role in the formation of antenna-like lipopolysaccharides on the surfaces of bacterial cells. Lipopolysaccharides have numerous functions---helping bacteria defend themselves against host immune respo...Safer estrogen targets painful intercourse in older women
... eventually be developed into a topical cream that targets and smoothes wrinkles without affecting other tissues. Future studies are anticipated....Early trial at Thomas Jefferson University Hospital shows Angiostatin is safe
...cs, or the drug's effects on potential biochemical targets that affect blood supply to the tumor. The scientists gained some valuable insights in the trial. "We learned that in some patients, a 10 minute treatment won't be enough," says Dr. Capizzi. "Given the safety, the laboratory tests that reflect how t...Study points to potential role for caffeine in reducing the risk of Parkinsons disease
...xpression is restricted to the very cells that are targets of the dopaminergic neurons that go awry in Parkinson's disease. "The A2A receptor has a distinct advantage when it comes to treatment because it exists for the most part where you want to target your therapy. So there may be fewer side effects," say......nown as a glitazone or thiazolidinedione) directly targets insulin resistance. Insulin resistance is a funda...ighlights that unlike traditional therapy, AVANDIA targets both fundamental causes of Type 2 diabetes insulin resistance and beta-cell function. The results ...High-dose radiation treatment effective at fighting some cancers in children
...tion therapy (a treatment that targets the tumor through layers of healthy, normal tissue). "A single dose of high-dose radiation isn't enough to eradicate the disease," Nag said. But applying the one-time high dose of ...Scientists succeed in blocking transmission of cell-associated AIDS virus
...iated viruses may not be blocked by a vaccine that targets the naked virus. First author Kristen Khanna, PhD, a research associate in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health, notes, "While considerable effort has been directed toward the ...Duke researchers identify the mechanisms by which drug combinations kill fungal infections
...lly eradicated fungal infections, but the cellular targets and the mechanism of drug action were not understood. Elucidating the molecular targets could open the door for new or improved drugs, Heitman said. "The big question was, What are the mol...Mayo Clinic study finds radioactive drug samarium hopeful new treatment for osteosarcoma
...ncer further hope of a treatment that specifically targets and kills tumors in the bone. In the study, 24 of ...or osteosarcoma. The beauty of samarium is that it targets the tumors in the bone and kills off the cancer cells, says Dr. Anderson. Because it is bone-specifi...UNC, Wake Forest scholars work to reduce crimes against Hispanics in North Carolina
... 1990 to 4.7 percent in 2000, have become favorite targets of thieves. More importantly, the investigators have produced educational materials including Spanish-language brochures, public service announcements, a photographic storybook, or photonovela, and videos to try to reduce such crimes. The N.C. Gover...Gene therapy to treat angina appears safe
...circulatory system. This indicates that the agent targets and tightly binds to heart cells. The researchers compared each subjects exercise treadmill time (ETT) before and after therapy or placebo. At the beginning of the study, average ETT was 9.4 minutes for the placebo group, and 9 minutes for the treat...Not working alone at night, outside lights can cut workplace homicides, study shows
... lighting, efforts to make businesses unattractive targets for robbery tended to have little effect on the risk of death resulting from domestic and other disputes involving workers, the authors found....HIV protein stops cell division, leading to more virus and sicker patients
...nter HIV, some of these immune system cells become targets for infection. Once infected, T cells begin producing HIV. New research at the Gladstone Institute of Virology and Immunology is showing how the virus coerces T cells into becoming very efficient virus factories. At the center of it is the HIV prote...Chemical attraction needed to launch an immune attack
... for example, neurons must find their way to their targets and muscle cells must interact and fuse. The role of chemokines or other chemical attractants uncovered in this study, creating zones that draw cells in depending on subtle changes in the amount of receptors arrayed on the cell's surface, may be a ge...NIAAA steps up search for brain mechanisms of alcohol abuse, alcoholism
...els to identify and study specific neurobiological targets for vulnerability to alcohol intake at the molecular, cellular, and neural circuit levels of analysis; to identify clusters of genes whose expression is regulated by alcohol ingestion and that are specific to a given behavioral model of excessive alc...Researchers demonstrate direct, real-time brain control of cursor
... used its thoughts to move the cursor to different targets for periods averaging two minutes in length. While this instant-control brain cursor was active, the real-time signals allowed the animal to correct wayward cursor movements "on the fly" in order to strike the target, the researchers said. This entir...Penn finds atrial fibrilation cure eliminates need for pacemakers, medicine
...to cure atrial fibrillation (A-Fib). The technique targets and isolates the triggers, or "hot spots," on pulmonary veins leading to the heart, preserving the heart's natural electrical circuitry and eliminating the need for a pacemaker or medication. Francis E. Marchlinski, MD, director of Cardiac Electr...MGH study finds herceptin has additional antitumor qualities
... of cancer. The new data show that herceptin also targets multiple factors secreted by cancer cells which maintain the tumor's blood supply. In the March 21 issue of Nature, researchers from the MGH Department of Radiation Oncology show that herceptin can reduce the diameter and volume of tumor blood vesse...Outsmarting cancer - new results from novel enzyme inhibitors
...tility may also be farnesylated and so may also be targets for farnesyl transferase inhibitors. Another key enzyme the 26S proteasome is also in the firing line for smart drugs. Proteasome is a protein complex that modulates the behaviour of cells during the cell cycle. It regulates the levels of key prote...... accidents combined. G8 leaders have set ambitious targets for reducing the global burdens of disease caused by tuberculosis, malaria, and HIV/AIDS by 2010, but why does violence against women, a massive cause of morbidity and mortality, remain overlooked by governments? They conclude: Violence against women...