UNC studies add new dimension to 'lock-and-key' theory of drug action
...tory in a variety of systems in which the receptor targets could be carefully controlled, Mailman said. The t...ms of action. Scientists may be able to take known targets and develop new drugs with much-improved clinical effects, Mailman said. We believe that this mechan...U-M study finds new target in war against graft-versus-host disease
...ejects cells in the host or patient. GVHDs primary targets are skin, liver and epithelial cells lining the stomach and intestines of the host. Damaged by heavy doses of radiation and chemotherapy used to destroy the patients cancerous bone marrow before the transplant, these cells secrete substances that act...Inert gas may help stop damaged nerve cells from dying
...e London had been investigating possible molecular targets which could be responsible for the action of different anaesthetics. In one experiment, he and his colleagues had found that xenon was capable of blocking the effects of a particular type of glutamate receptor the same receptor implicated in the pa...The Lancet Infectious Diseases (TLID)
...ether with a huge cash injection are needed if the targets for global TB control are going to be reached. New...trol efforts; they recommend strategies on how the targets will be reached. Leading edge - Sex matters for tuberculosis control. A much under-reported issue on...Scientists become filmmakers to decipher immunity
... visualizes the behavior of immune cells and their targets in intact lymph nodes. The publications open the ...ding of the interplay among immune cells and their targets has been inferred from looking at chemically stained cells in thin slices of tissues observed under ...Diabetes drugs may help multiple sclerosis sufferers
... this is a different class of drugs with different targets and effects." The study involved collaborations with researchers at several other universities and hospitals, including Dr. Michael Heneka of the University of Bonn in Germany, and was supported by a grant from the National Multiple Sclerosis Society...Gene expression profiles predict survival of lymphoma patients after chemotherpy
...e eligible. One option is PS-341, a new agent that targets a pathway in the cell that blocks chemotherapy. Gene expression profiling revealed that in DLBCL patients who do not respond well to standard chemotherapy, lymphoma cells have activated this pathway, known as NF-kB. Based on these results, a Phase ...Diet rich in foods with Vitamin E may reduce Alzheimers disease risk
...se include: Memory Impairment Study This study targets people with mild cognitive impairment, or MCI, testing the usefulness of vitamin E and donepezil to slow or stop the conversion from MCI to AD. (Study has completed recruitment.) Principal investigator: Dr. Ronald Petersen, Mayo Clinic, Rochester, MN...Diabetes targets will be impractical in routine practice
...has been advocated in type 2 diabetes. Yet current targets are attainable in only 50-70% of individuals in re... Queen Elizabeth II Hospital in Hertfordshire. The targets are often impractical and involve taking too many drugs, with which patients often will not comply, ...Drug resistance may prove more pervasive in African HIV
...ses of the potential for genetic variation in drug targets with an understanding of the complex thermodynamic.... "The next generation of inhibitors against known targets will benefit enormously from this work." To further study the interaction between mutation and drug ...Platelet molecule regulates blood coagulation, study finds
...e binding sites for phosphatidylserene may be good targets for drug design," he said....Brain tumor therapy needs longer treatment time
...xperimental treatment for high-grade brain tumors, targets diseased cells. In two separate studies of the uptake of BPA (boronophenylalanine) by cancerous brain cells, a group led by Subhash Chandra, a senior research associate with Cornell's Department of Chemistry and Chemical Biology, has found that the d...Discovery may lead to new HIV drugs, says Jefferson virologist
... was, what was it about T cells and some other HIV targets that blocked the virus from replicating, and which Vif somehow neutralized? Now, the discovery of CEM15 solves the mystery. "HIV can't make infectious virus particles from T cells or macrophages without it," he says. "If you can inhibit Vif, or stop ...Potent experimental drug shown to slow the growth of breast and prostate cancer tumors in mice
...tech, Inc., 2C4 is similar to Herceptin in that it targets HER-2/neu, a member of the HER kinase family of proteins. The protein sits on the surface of cancer cells and receives signals from "growth factor" molecules within the HER family, which, in turn, stimulate tumors to grow. "Although HER-2/neu is a...Sites chosen for public-private Osteoarthritis Initiative
...ow investigators to identify potential new disease targets and develop tools for understanding how to measure clinically meaningful improvements. As the U.S. population swells with graying baby boomers, vast numbers of people will suffer from osteoarthritis. Today, 35 million people -- 13 percent of th...Promising vaccine may provide long-lasting protection against malaria
...vaccine, according to Seeberger. The new vaccine targets the toxin instead of the parasite. Although the parasite itself lives, it is rendered harmless by the destruction of its deadly toxin, he said. One or two shots of the vaccine are expected to provide lasting protection against the disease. If necessa...Novel kidney transplant technique prevents rejection of donated organs
...antibodies against their donors' HLA antigens, the targets of rejection, and maintained that status for an average of 13 months post-transplant. Most organ rejection occurs during the first three months following surgery. "I've been in this business 30 years and I've never seen anything like these result...Fred Hutchinson receives $12.7 million to lead prostate-cancer consortium
...w disease progression could help identify new drug targets and new genes that are linked to tumor metastasis. Project leaders: Leroy Hood, M.D., Ph.D., co-founder and president, Institute for Systems Biology, and UW affiliate professor of bioengineering, immunology, and computer science and engineering; and ...Macrophages from human lymphoma patients cause mouse lymphoma in mice, UCSF study finds
...the UCSF Lymphoma Program. This trial specifically targets individuals with relapsed HIV-associated lymphomas. A second trial for patients with other (non-HIV) lymphomas is expected to open before the end of this year....European trial finds old lung cancer treatment may still be best
...herapy. This can be achieved by identifying novel targets related to the distinctive properties of cancer cells and we have promising novel biological agents in the pipeline that can be combined with standard chemotherapy in locally advanced or metastatic NSCLC."...