Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
...s the immune system in recognizing cancer cells as targets for attack, but it depends on the existence of healthy T cells to launch and sustain the immune response. "The immune system will try to fight off a malignant brain tumor but because it does not accomplish this very effectively, we're trying to enhan...Radical solutions found to meet limits on junior doctors' hours
... inflexible systems for monitoring compliance with targets are putting professionalism at risk....FDA-approved drugs shown to lower Alzheimer diseaserelated protein levels in mice
...e treatment of prostate and colon cancer, directly targets gamma-secretase and the conversion of APP to Abeta42 without inducing toxic gastrointestinal or renal side-effects associated with some NSAIDs. In their accompanying commentary, Drs. John Cirrito and David Holtzman from Washington University in St. L...JCI table of contents, 1 August 2003
...e treatment of prostate and colon cancer, directly targets gamma-secretase and the conversion of APP to Abeta...anted mineralization and provide novel therapeutic targets for preventing ectopic calcification in degenerative diseases. TITLE: The serum protein alpha2Herema...Fred Hutchinson Cancer Research Center study shows retinoids kill childhood brain tumor cells
...noid-induced cell-death cascade could be potential targets for new anticancer drugs. A proposed clinical trial for high-risk pediatric medulloblastoma patients to compare standard therapy plus retinoids to standard therapy alone is now under review by the Children's Oncology Group, a National Cancer Institu...First human tests under way of HIV vaccine pioneered at UNC
...rate VEE virus or cause VEE infection. The vaccine targets cells in lymph nodes, the critical tissue of the immune system. The vector will produce the immunizing protein by expressing "gag," a major protein in the HIV particle. The protein then induces the body to respond immunologically to it. More advanced...Eliminating hunger in a world of plenty
...ich create a gap between rich and poor, become the targets of change. ADA's position is that while individuals and groups work to improve the well-being of all people, worldwide efforts to overcome hunger, food insecurity and malnutrition must be intensified. "It is vital for dietetics professionals to beco...Stanford research shows targeted DNA vaccine may reverse autoimmune disease
...ng the microarray information to guide them to the targets of the autoimmune response in the sickest mice, Ga...n noted, is that it allows for multiple autoimmune targets to be tolerized simultaneously rather than one at a time. "We found that this approach broadly turns...UCI researchers identify link between infant seizures
... opportunity for therapeutic drug development that targets controlling seizures in epilepsy."...Subversive strep bug strategy revealed
... the investigators have exposed dozens of possible targets for drug therapies. These findings are likely to be broadly applicable to many types of microorganisms that cause disease in humans, and could lead to new treatments that augment the immune response against multiple pathogens," he adds. Neutrophils ...Mouse study gives new view of anthrax toxin
...rtant step, she adds, will be to identify the cell targets of LT and determine precisely how it initiates the chain of events leading to death. Researchers at the National Cancer Institute also contributed to this research....University of Illinois at Chicago receives $15.7 million grant to stop anthrax
...ject one will identify and validate new antibiotic targets in ribosomal RNA. Alexander Mankin, professor of m..., will identify and validate new infection-related targets in B. anthracis. Project three, led by Johnson, will use structure-based design and high throughput ...Adequate anticoagulation reduces impact of stroke for patients with atrial fibrillation
...nts with atrial fibrillation should have lower INR targets to reduce the risk of hemorrhage, but the researchers note that INR targets less than 2.0 increase the likelihood that a stroke will be fatal or debilitating. "All anticoagula...Interim analysis comparing TDF to EFV in combination with 3TC + ABC
...asic research programs designed to investigate new targets to treat HIV....Pharmacokinetic data presented at ICAAC on investigational HIV protease inhibitor 433908 (908)
...asic research programs designed to investigate new targets to treat HIV....New blood test could detect lung cancer in its earliest stages
...echnique is a new paradigm for identifying protein targets in cancer, because we are zeroing in on the disease-causing protein itself rather than searching for a defective gene and then hunting down its relevant proteins," said Patz. Patz described his methods and results using MALDI-TOF MS (matrix-assisted ...Different approaches required for monitoring suicide trends
...r men. Health programmes in many countries include targets for reducing suicide. The conventional method for measuring population suicide trends involves analysis of suicides across all age-ranges combining male and female suicides. David Gunnell and Nicos Middleton from the University of Bristol, UK, propos...Making tiny plastic particles to deliver lifesaving medicine
... the mucus lining in the lungs to reach their cell targets underneath. Reports on this work are expected appear shortly in the "Journal of Biology Chemistry," "Biotechnology Progress" and the "Journal of Aerosol Medicine." Earlier this year, in "Proceedings of the National Academy of Sciences," Hanes, Wirtz ...Research offers insight on treatment for hereditary eye disease
...t can eventually lead to blindness. The research targets the mutation of a specific gene that can trigger retinitis pigmentosa (RP), a hereditary disease that affects 1.5 million people worldwide, many of whom are legally blind by the age of 40. The study, appearing in the October 3 issue of the Journal o...Pneumococcal vaccine significantly reduces disease in South African children
...itis, and is administered in infancy. The vaccine targets seven strains of pneumococcal disease, while the vaccine used in the South African clinical trial targets two additional strains of pneumococcus that are prevalent in developing countries. The 9-valent con...