Tag: "thymic" at medical news
JCI table of contents, January 20 2005
...html T cell escape from thymic
Alcatraz The immune response must walk a fine line between mounting effective responses against foreign invaders without generating harmful immune responses to self. Just how T cells maintain this tolerance to self is not fully recognized. During T ...
Canadian researchers' important discovery in HIV research
...the first months following the onset of infection, thymic
function is decreased. Such a decrease results in a lowered T-lymphocyte production by the thymus. These findings pave the way to the development of novel immunotherapies of HIV-infected individuals. Such immunotherapies could be also applicab...
Pitt receives $14.5 million from NIH to improve pediatric heart transplantation outcomes
.... Preliminary results in 14 patients who received thymic
injections indicated significantly fewer "late" rejection episodes and less immunosuppression requirements one to five years after the procedure compared to 23 patients who did not receive donor bone marrow. Through the grant, these patients will con...
Age-related outcomes, immune response in patients with brain tumors linked to thymic cells
... the bloodstream from the thymus are called recent thymic
emigrant (RTE) CD8+ T lymphocytes. "Our findings ... that levels and function of newly produced recent thymic
emigrant CD8+ T cells critically influence age-dependent mortality and exert one of the strongest kn...
'Genetic switch' proves two mechanisms exist by which immune system cells differentiate
...s in the thymus required for T-cell maturation are thymic
epithelial cells (TECs). In the mutant nude mouse,...called "crosstalk" is needed for the growth of the thymic
epithelial cells. "Normal nude mice never even start to develop T-cells, because the TE cells remain...
Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
...ck on the tumor. Changes to the thymus and "recent thymic
emigrant" (RTE) T cells are similar to those seen ...ording to the study. "It appears that these recent thymic
emigrant T cells preferentially home to gliomas or they have an enhanced anti-tumor activity that al...
Scientists become filmmakers to decipher immunity
...in an organ called the thymus, interact with other thymic
cells that support their maturation. Ellen Robey,...me immature T cells remained in contact with other thymic
cells increased when those thymic
cells carried surface proteins that helped the T cells mature. Th...
Sniffing Out The Promise Of Anti-Angiogenesis Therapy
...tin-have not yet reached Phase I trials.) IM862, a thymic
dipeptide, a small protein, was developed by Cytran, Inc., aprivate held company located in Kirkland, Wash. It does not go after tumor cellsdirectly-in fact, says Gill, "it is not cytotoxic to any tumor cells." Itinhibits blood vessel formation and/...
Study Offers Hope For Immune Reconstitution After HIV Infection
...ined increase in TRECs. "Our findings suggest that thymic
function is suppressed in HIV-infectedindividuals ...," says Dr. Koup. "Therapies that directly improve thymic
function may increase the rate of immunereconstitution after HAART." The study's project officer, Pa...
Means To Predict Which HIV+ Infants Will Rapidly Develop AIDS Outlined By Emory University Researchers
...ge syndrome. Children with DiGeorge syndrome have thymic
defects and characteristically low CD4+ and CD8+ T...ross the placenta during gestation) to cause early thymic
disruption... "In addition to their pathogenetic importance, our findings have clinical implications...
AIDS Treatments Seek To Eradicate Virus, Restore Immunity
...pe toreconstitute a new immune system from healthy thymic
tissue in patientswhose own thymus has been destroyed or crippled," she said. "Bykeeping the viral load extremely low, the drugs may protect the thymus andallow it to produce new T-cells." The third arm of protocol 1 is a novel effort to boo...