U of M researcher says Viagra may cause permanent vision loss in some men
... ratio means that the blood vessels and nerves are tightly bundled together into the small space in the back ...disk ratio, where the blood vessels and nerves are tightly bundled provoking NAION," says Pomeranz. The onset of NAION within hours after ingestion of Viagra ...A marker for new blood vessel formation in tumors
...eled glycopeptide, ([18F]Galacto-RGD), which binds tightly to a receptor - αvβ3 integrin -expressed in some tumors, especially in the blood vessels. As well as a role in angiogenesis, integrins are important in holding tumor cells together and connecting them with the extracellular matrix; what ha...Study finds new designer drug is potent treatment for chronic myelogenous leukemia
...o grow too quickly. However, it does not bind very tightly to this protein, and patients can develop a resistant type of Bcr-Abl that no longer binds to Gleevec at all. Using rational drug design to circumvent these shortcomings, researchers at Novartis determined the crystal structure of Bcr-Abl, and then ...Study finds new designer drug is potent treatment for chronic myelogenous leukemia
...o grow too quickly. However, it does not bind very tightly to this protein, takes a long time to induce remissions, and patients can develop a resistant type of Bcr-Abl that no longer binds to Gleevec at all. To circumvent these shortcomings, researchers at Novartis determined the crystal structure of Bcr-A...Tracing the life cycle of a manmade disease
... a high dose of irradiation to bond molecules more tightly together, producing a much stronger and more durable material. Out of this MGH-MIT collaboration emerged a highly crosslinked, ultra-high-molecular-weight polyethylene. The research team improved and refined the material by putting it through a me...Research in yeast yields missing link in DNA maintenance machinery
...o DNA. Inside cells, long strands of DNA are wound tightly around a series of proteins called histones. The c...rganized within the chromosome, said Shen, but DNA tightly wound around histones is inaccessible. If DNA becomes damaged by radiation, reactive chemicals or ul...Antibiotic rifampicin shows promise for fighting Parkinson's disease in lab tests
...ound that the drug and its breakdown products bind tightly to alpha-synuclein, possibly even reacting with it to form a stable compound. Their findings with rifampicin are very similar to previous research in Fink's lab with the compound baicalein, a flavonoid that also inhibits fibril formation and d...Stem cells' repair skills might be link to cancer
...he edge. "Normal stem-cell self-renewal is a tightly regulated process, so the question is how and whether such regulation is circumvented in cancer," says Beachy. Beachy says the place to start looking is the activity and regulation of Hedgehog and Wnt, which are best known for their roles in e...Learning to cover up reduces risk of skin cancer
...ams might be limited by available staff time or by tightly scheduled swimming classes, speculates Saraiya. The tourist industry might also be skittish at first about warning vacationers away from their prime reason for visiting beaches or ski resorts, says the task force, but that could be offset by an appre...New protein 'stop sign' alters blood vessel growth
... it. They discovered that the Sema3E protein bound tightly to the monkey cells and created a signal. Surprisingly, the two proteins didn't need a third that is known to work with semaphorins in other situations. To see how each of these three proteins affects blood vessel migration, Gu and colleagues from H...Close control of blood pressure associated with fewer eye problems in patients with type 2 diabetes
...nd hypertension who kept their blood pressure very tightly controlled had fewer eye disorders caused by their diabetes, according to an article in the November issue of The Archives of Ophthalmology, one of the JAMA/Archives journals. According to the article, type 2 diabetes and hypertension are often assoc...Advances in plasma physics at Annual APS Meeting
...echniques for accelerating electrons are producing tightly focused, energetically uniform beams in compact devices that will be ideal for numerous scientific and medical applications. The accelerators, known as laser wakefield devices, are only meters in length and could replace accelerators that are current...Advances in plasma physics at Annual APS Meeting
...echniques for accelerating electrons are producing tightly focused, energetically uniform beams in compact devices that will be ideal for numerous scientific and medical applications. The accelerators, known as laser wakefield devices, are only meters in length and could replace accelerators that are current...News tips from the Journal of Neuroscience
...hinji. The cortex is made up of tightly organized layers of neurons, each with a distinct function. Now, Hasegawa et al. outline a scenario in which signaling by fibroblast growth factor (FGF) and the Pea3 subfamily of Ets transcription factors mediates the migration of subsequent generati...Alzheimers disease - recent discoveries pave the way toward new treatments
...spatial learning and memory in our mice correlated tightly with the depletion of calcium-dependent proteins in specific brain regions. Similar abnormalities were then found in brains from patients with Alzheimer's disease, and the greatest depletions were seen in the most severely demented people." Mucke's t...Solvent, common drug plus hormones raise risk of reproductive failures and breast cancers
... "Estrogen produces effects inside cells in a very tightly controlled manner, so skewing that process by accelerating transcription can produce a variety of problems," said McDonnell. In order for MAA to accelerate the transcription process, however, estrogen or some other hormone must be pre...Latest cancer research features small molecule therapy, and the preventative benefits of sunshine
...e small molecule PPARgamma agonist, RS-5444, binds tightly to the cellular receptor in cell lines derived from human anaplastic thyroid tumors, and inhibits growth of those cells in culture. The treatment is effective in in vivo models as well. "In the nude-mouse animal model injected with the tumor cells...Cognitive behavior therapy effective for treating people with hypochondria
...ute sessions at weekly intervals. Each session was tightly scripted and devoted to 1 of 5 factors that cause patients to amplify symptoms and misattribute them to serious disease: attention and bodily hypervigilance, beliefs about symptom etiology, circumstances and context, illness and sick role behaviors,...Study: Carbon dioxide may find new use in producing medical implants
...nstead -- an effect Tomasko suspects is due to the tightly packed polymer chains that make up the plastic. "We think the CO2 lubricates the polymer chains so the protein molecules can slip in-between," he said. For the next step in this research, the engineers will be working with biodegradable plastics and ...Jefferson scientists unlocking secrets of cholesterol transport in body
...ns Caveolin 1 and Annexin 2 were bound extremely tightly in the intestines. When this association was disrupted in zebrafish embryos, they absorbed a cholesterol "analog" more poorly. The scientists also found a similar close association of these proteins in mouse intestinal cells not found in other cell...