Tag: "tolerance" at medical news

Pitt transplant researchers say anti-rejection drug rapamycin may help lupus, some cancers

...ut there are important implications for transplant tolerance as well," added Timucin Taner, M.D., a pre-doctora... harness the dendritic cells' potential to promote tolerance of transplanted organs. Further studies will look at how rapamycin affects dendritic cells and the t...

Frozen food research receives historical recognition

... designate the research known as time-temperature tolerance studies as a National Historic Chemical Landmark....eriments, which came to be called time-temperature tolerance studies, were conducted on frozen fruits, juices, vegetables, poultry, beef, precooked foods and bak...

New buzz on coffee: It's not the caffeine that raises blood pressure

...inking caffeinated espresso, both of which suggest tolerance to coffee does not appear to be related to caffeine. He concludes that the potential adverse effects attributed to coffee could be less hazardous in regular consumers with normal blood pressure. In such people, especially those without a hereditary...

Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases

...hildren's Hospital of Philadelphia achieved immune tolerance in mice, allowing donor cells to multiply without toxic side effects. The studies appear in related articles in the August and September issues of Blood. The finding could greatly broaden the use of cell and organ transplants for genetic diseases de...

Researchers discover 'doorways' into brain cells

...e to imagine developing techniques to control drug tolerance or sensitivity to a therapeutic agent such as an antidepressant by preventing the relevant receptors from migrating to or entering the endocytic zones to undergo endocytosis," said Ehlers. More broadly, he said, the discovery of endocytic zones could...

Starzl Institute researchers to develop cell-based strategy for tranplant tolerance

... type of immune system cell can help induce immune tolerance in kidney transplantation. Specifically, the rese..."We are hopeful that a clinical strategy to induce tolerance in transplant patients will emerge from these studies in nonhuman primates. Indeed, it is everyone's...

Opioids should be considered for relief of chronic lower back pain

...ith long-term adverse effects. * Development of tolerance and need to increase dosage over time: Available studies indicate that opioid dosage remains fairly stable over time and benefit is maintained; however, many of the published studies are of relatively short duration. * Risk of drug dependence and ...

Type A and cant handle it?

... Mice lacking this key protein had reduced cardiac tolerance for both exercise- and adrenaline-like stress. Nearly three-quarters (73 percent) of the Kir6.2-deficient mice died within 14 minutes after a stressor challenged their cardiac response -- yet all the mice that possessed Kir6.2 survived the stress tes...

UT Southwestern researchers find clue to understanding tolerance to drugs of abuse

...elp brain researchers better understand a person's tolerance to drugs of abuse and open new avenues of investigation into the relationship of addictive-drug usage and the biological causes of mood disorders. Dr. Michel Barrot, assistant professor of psychiatry at UT Southwestern and lead author of the paper, s...

Strategies allow for drug-free transplants, report researchers at international congress

...s process, the ensuing steps in the development of tolerance cannot occur, he explained. Results presented today by Dr. Kareem Abu-Elmagd, associate professor of surgery at the University of Pittsburgh's Starzl Institute, involved 22 recipients of small intestine, liver/small bowel and multivisceral transplant...

Combined kidney and bone marrow transplantation allows patients to discontinue anti-rejection drugs

...enters. "Our results demonstrate that long-lasting tolerance can be induced with non-myeloablative bone marrow ... new study of the induction of mixed chimerism for tolerance in patients without cancer who need kidney tranplants." That investigation, also sponsored by the I...

Testing earlier for gestational diabetes a smarter way to screen pregnant women

...g/dL, they were sent for additional formal glucose tolerance testing. "Women who had a 16-week glucose screeni... during pregnancy go back to having normal glucose tolerance after the birth of the baby; however, these women may be at greater risk for adult onset diabetes me...

Tolerance for alcohol associated with family history

... with a family history of alcoholism may develop a tolerance that causes them to drink more in order to feel th...that the findings "suggest that the development of tolerance may maintain or increase drinking in people with a family history of alcoholism; i.e., they imbibe m...

Alcohol tolerance associated with family history

... with a family history of alcoholism may develop a tolerance that causes them to drink more to feel the same ef...ticipants. "This suggests that the development of tolerance may maintain or increase drinking in people with a family history of alcoholism. In other words, the...

Research helps explain why perception of pleasure decreases with chronic cocaine use

...ug addiction. The study's findings also show that tolerance does not result from a decreased effect of cocaine on basal reward thresholds, but results instead from the establishment of a new basal reward threshold, above the initial threshold. As a result, more doses are progressively needed to maintain the...

Eficiency, feasibility of antiretroviral therapy in Africa demonstrated in IRD-coordinated surveys

...t to lift doubts surrounding the effectiveness and tolerance of antiretroviral therapies in Africa. It uses now-standard tritherapy regimes. Dr Ibrahima Ndoye of the Senegal National Committee for Aids Control (Comit national de lutte contre le sida du Sngal ) and Prof Eric Delaporte of the French lnstitut de ...

Vaccination delays onset of prion brain disease in mice

...the new study shows that it could break the body's tolerance to prion protein by inducing an immune response in the form of antibodies in mice. Most importantly, higher antibody levels were found in the animals who resisted the disease for the longest period of time, bolstering the evidence that these antibodi...

Detection of glucose intolerance after heart attack

...e hospital stay, and did standardised oral glucose tolerance tests with 75 g of glucose at discharge (four to f...ter. 35% and 40% of patients had impaired glucose tolerance at hospital discharge and after three months, respectively. 31% and 25%, respectively, had previousl...

Detection of glucose intolerance after heart attack could identify risk of cardiovascular disease

...e hospital stay, and did standardised oral glucose tolerance tests with 75 g of glucose at discharge (four to f...ter. 35% and 40% of patients had impaired glucose tolerance at hospital discharge and after three months, respectively. 31% and 25%, respectively, had previousl...

Heavy drinkers seem to get a bigger 'bang' from alcohol than do light drinkers

...ggesting that not only do heavy drinkers have more tolerance to alcohol-induced sedation but they also have more stimulation. The combination of these effects, more stimulation and less sedation, is like driving a car with a powerful engine but with faulty brakes. It is fun to drive, but may eventually get yo...

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