Tag: "tolerance" at medical news

Early intervention stops damage to insulin-producing cells

...ry start saw their insulin sensitivity and glucose tolerance tests remain stable. But among the 65 women who st...acute insulin response fell by 39 percent. Glucose tolerance test levels rose by 10 percent, indicating growing levels of sugar in the blood. When the researcher...

Acarbose could delay onset of type-2 diabetes

...venting or delaying conversion of impaired glucose tolerance to type-2 diabetes. Around 1400 patients from Cana..., Finland, Israel, and Spain with impaired glucose tolerance were randomly assigned 100 mg acarbose or placebo three times daily. The primary endpoint was the de...

130-year-old mysteries solved: how nitroglycerin works; why patients develop tolerance

... nitroglycerin -- whypatients eventually develop a tolerance to the drug's effects. Shortly after heart patients take nitroglycerin, the blood vessels supplying the heart musclerelax, allowing oxygen-rich blood to nourish the heart and relieve the pain. While it is knownthat nitric oxide -- a breakdown produc...

High tech sky tech

...andwidth, hardware engineering difficulties, fault tolerance (the adaptive ability to protect and heal itself from the environment as well as from attack), not to mention demanding wireless communication networks (what Allen calls "Internet in the Sky") needed by all these vehicles (some moving at 300 mph). "...

Studies yield key insights in preventing destruction of insulin-producing cells

...nth period. "The goal of this trial was to induce tolerance to the beta cell, which is the target of autoimmune destruction in type 1 diabetes. This was in effect achieved, because the clinical effect we saw persisted long after patients had finished treatment with the anti-CD3 antibody," said the lead author...

Ginseng berry extract shows promise for diabetes, obesity

... Treated mice also had better scores on a glucose tolerance test, which measures how quickly the mice could remove excess glucose from the blood. The extract caused diabetic mice, which were also obese, to lose more than 10 percent of their body weight in 12 days. Untreated mice gained five percent of their ...

Blocking adhesion protein may reduce lung damage from radiation

...dulation of ICAM-1 may well help improve radiation tolerance of the lungs, it is unlikely to completely prevent lung injury. However, Kachnic and Powell note that ICAM-1 deficiency could be integrated with other factors affecting radiation-induced lung damage and that future studies looking at these relatio...

Special cell prevents diabetes in mouse model, report University of Pittsburgh researchers

...chers discovered in previous studies of transplant tolerance originates in the liver. Moreover, instead of causing T cells to proliferate, they found that this dendritic cell, called B220+DC, caused the T cells to die, through a process called apoptosis, and at a rapid rate. Because T cells are the main antag...

Annals of Internal Medicine tip sheet, April 16, 2002

...et type 2 diabetes as well as the standard glucose tolerance test did (Article, p. 575). The model used informa...drug therapy). An alternative for the oral glucose tolerance test is good news for many reasons: type 2 -- or adult diabetes -- can be prevented with lifestyle c...

JDRF launches multimillion-dollar Center for Islet Transplantation at Emory University

...arch must now focus on conquering autoimmunity and tolerance issues." Renowned researchers at Emory University...hers will perform pre-clinical studies and examine tolerance induction to islet grafts using the co-stimulation blockade approach in non-human primates. Other pr...

Chemotherapy trial proves the worth of including elderly patients in clinical trials

...s in this population. For instance, the excellent tolerance observed in both arms of our trial was surprising. Oncologists should be encouraged to enrol the elderly in clinical trials....

Alcohol and nicotine: A deadly duo

...ne, alcohol or both tend to develop some degree of tolerance to one or both drugs Therefore, he said, they may need to smoke more and drink more to achieve the same high as casual [users]. The second study examined the impact of mecamylamine on the pharmacokinetic, stimulating, and pleasurable effects of alc...

Delaying disability in elderly

...tors had previously been shown to improve exercise tolerance in people with heart failure. Researchers thought this effect was related to the drugs positive action on the cardiovascular system. To test a theory that the drugs can affect muscle function, Onder and colleagues analyzed data from the Womens Hea...

Many obese youth have condition that precedes type 2 diabetes

...ty in children and youth who have impaired glucose tolerance will help to prevent their developing type 2 diabe...hers found that the children with impaired glucose tolerance frequently had insulin resistance, a condition that usually precedes type 2 diabetes in adults and i...

Yale study shows 25 percent of obese children are at high risk for developing diabetes

... risk for complications from diabetes." A glucose tolerance test evaluates the bodys capacity to metabolize gl...adolescents. All underwent a two-hour oral glucose tolerance test during which glucose, insulin and C-peptide levels were measured. The glucose intolerance was ...

Alcohol researchers find genetic locus of human brain wave

...mal studies implicates GABAA in the development of tolerance to and dependence on alcohol and in genetic liability for alcoholism. Among its many functions, GABAA serves as the gatekeeper for neurons that influence beta EEG frequency. Scientists have speculated that some perturbation of GABAA activity is respo...

NIAAA steps up search for brain mechanisms of alcohol abuse, alcoholism

...ects of drinking alcohol that evoke repeated use), tolerance (the need for increasing amounts of alcohol to produce a desired effect), sensitization (increased response to alcohol after repeated intermittent exposures), withdrawal (negative symptoms occurring with abrupt discontinuation of chronic alcohol cons...

Multimillion-dollar pain research center funded at Wake Forest

...anges in the nervous system that produce increased tolerance to narcotics such as morphine commonly used to treat pain. The research will study whether adding other medicines can stop or reverse those changes. A third project will attempt to determine why certain pain-relieving drugs are much more potent in ...

Pitt's transplant team uses standard stem cell procedure in unique way for recipient of living donor kidney transplant

...from a living donor as a means to induce drug-free tolerance of the transplanted organ. On Jan. 11, a 54-year-o...o boost the level of chimerism, with the idea that tolerance is more likely to follow and successful weaning can occur. (None of the bone marrow patients have be...

Researchers identify a key 'brake' of the immune response

...t of ILT3 and ILT4 on dendritic cells could create tolerance to foreign tissues, such as donor tissue or bone m...f the immune response and then creating a state of tolerance to antigens, which can be foreign or derived from the body itself, explains Dr. Suciu-Foca. To shut ...

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