Study: growth hormone-deficient young adults need larger replacement doses than older adults
...e older adults need less growth hormone and cannot tolerate it as well as children. "Besides the placebo, which is inactive, we tested a dose of 25 micrograms per kilogram of body weight per day and also a dose that was half that large," Underwood said. "The 25 microgram dose is about half of what is used in ...Benchmark study of brain tumors points to resection over biopsy as one key to survival
...a craniotomy, for instance, because they could not tolerate a general anesthetic," Laws said. "Age and general health are also key variables in survivability, with younger, more active patients more able to benefit from glioma treatment." The patients who were part of the project had either Grade III g...Delays in heart attack care erode the difference between two emergency therapies
... add that high-risk patients, and those who cannot tolerate clot-busting drugs because of other medical conditions or medications, should still get angioplasty even if the delay is slightly longer. The current study does not adjust for individual patients' risk factors, but rather looks at patients in groups ...Stanford research shows targeted DNA vaccine may reverse autoimmune disease
...n. In this process, the immune system is coaxed to tolerate an offending protein after injection of that same protein or pieces of it. Utz, MD, assistant professor of medicine (immunology and rheumatology), likens the process to allergy shots: the agent causing the allergic reaction is injected into muscle in...Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases
...use prenatal interventions to help the body safely tolerate treatments for genetic diseases." Dr. Flake's team used a prenatal procedure called in utero hematopoietic stem cell transplantation (IUHSCT). Hematopoietic stem cells develop into red blood cells, white blood cells and a variety of immune cells. The...Doctors surprised that older women patients can tolerate powerful treatment
...seilles, France, has shown that older patients can tolerate powerful medication too. Speaking today (20 October 2002) at the European Society for Medical Oncology Congress in Nice, France, Dr Anne Chantal Braud called for a standardisation in the treatment of the elderly. Dr Braud and her team examined the e...Opioids, narcotic analgesics effective in treating post-herpetic neuralgia
...pramine as the alternate. (Patients who could not tolerate the primary treatment drugs were offered the alternate drug of the same class within the treatment period.) Pain intensity ratings, pain relief, and cognitive function were the primary outcome measures. Greater mean decreases in pain ratings follo...Doppler-guided fluid administration during surgery improves outcome
...o nausea and vomiting, as well as the inability to tolerate solid food. "When the gut is stressed by lack of perfusion, it is also hypothesized that the bacteria that normally inhabit the gut can enter the bloodstream, which can lead to a host of additional problems, including sepsis, which tend to prolong ho...Fred Hutchinson Research Center awarded $7 million grant
...usands of blood cancer patients whose inability to tolerate more toxic therapies leaves them without access to the most effective means of combating their diseases." "The SCOR award provides us the opportunity to integrate multiple approaches that were pioneered at Fred Hutchinson to develop new, more tolerab...Water may prevent some fainting spells
...er increased the time that test participants could tolerate remaining at a 60 degree angle to an average of 40.9 minutes, vs. 33 minutes without water. Those who drank water had a smaller decrease in heart rate associated with tilting than those who didn't drink. Schroeder's group had nine women and five men...New combination treatment for hepatitis C reported more beneficial than standard therapy
...reases in some of the most common and difficult to tolerate adverse events associated with hepatitis C therapy." Of the six different strains, or genotypes, of hepatitis C, approximately 70 percent of people in North America are infected with genotype 1. The study was funded by Hoffmann-La Roche, the maker...New data suggests chemotherapy patients benefit from heart failure treatment
...e beta-blocking agent carvedilol, unless unable to tolerate therapy. Ten patients had baseline left ventricular ejection fraction (LVEF) of less than 40 percent and six patients had LVEF of greater than 40 percent. Results showed that carvedilol treatment alone yielded a mean increase in ejectionfraction u...American Thoracic Society Journal news tips for September (second issue)
...users find the discomfort of the mask difficult to tolerate for more than brief periods. He hopes that out of this disaster will come new ways of protecting the respiratory systems of those who risk their lives to save others. The research and editorial appear in the second issue for September 2002 of the A...New procedure kills liver tumors without surgery
...malignancy in her bones, but she sees no reason to tolerate new tumors elsewhere if they can be destroyed. "I approach it from a common-sense perspective," she said. "If they're not there, they can't grow larger." Adds Harris' daughter, Ross, "RFA gives you another way to have hope, which is what we're all...Duke researchers develop method to make safer drugs
... Using plasma samples from six patients who cannot tolerate heparin, researchers showed the newly created anticoagulant worked and that the antidote could reverse the blood-thinning effect of heparin. "Our study shows that once you've administered the blood thinner and then add an antidote, within 10 minutes...Combined kidney and bone marrow transplantation allows patients to discontinue anti-rejection drugs
...cancer, and the kidney failure made them unable to tolerate the toxic aspects of standard bone marrow transplantation, which has been used for some myeloma patients. For many years Sykes and her colleagues at MGH -- along with collaborators at BioTransplant Incorporated of Charlestown, Mass. -- have been stu...DARPA to support development of human brain-machine interfaces
...earchers. They have already shown that animals can tolerate the electrodes for periods of years without apparent harm. According to Nicolelis, the technology and computational methods developed under the DARPA support also will lead to a deeper understanding of the brain itself. "This research will provide...Time-release stimulant effective for once-daily treatment of ADHD
...another treatment opportunity for those who cannot tolerate other stimulant drugs." More than 500 children aged 6 to 12 who met standard diagnostic criteria for ADHD enrolled in the study at 47 sites across the country. Participants were randomly divided into four groups, and after a one-week "washout" perio...Annual study reveals 23 football players died during 2001 season
... and thus it is likely players were better able to tolerate hot weather. Mueller and other experts strongly recommend pre-practice physical examinations for boys -- and the small number of girls -- who want to play football. Such exams sometimes reveal hidden conditions that make heavy exertion hazardous. Par...Northwestern researcher calls for simplified, less toxic HIV therapies
... the likelihood that a patient will not be able to tolerate or adhere to therapy," Murphy said. Murphy discussed potential new HIV treatments, particularly atazanavir, a single-daily-dose protease inhibitor currently undergoing clinical trials, that has been found to be well tolerated and causes virtually no...