Tag: "toxic" at medical news

Scientists Produce New Anti-Malarial Compound

...trons and breaking molecular bonds,making the drug toxic to the malaria parasite. "Our understanding of that mechanism has allowed us to designstructurally simpler compounds that would follow that chemicalmechanism," Posner said. The new compounds have a similar oxygen-oxygen bond, therebyenabling the same...

Substance from Grapefruit Juice May Make Medications Safer

...ug that may be effective for one individual can be toxic to another. Addition of the active substance in grapefruit juice to a medication could produce a drug for which a standard dosage would be equally effective in everyone. What should people who regularly take drugs that are metabolized by CYP3A4 do?...

TB Prophylaxis Unnecessary In HIV-Infected People With Anergy, Study Suggests

...e of INH would allow many people to avoid theknown toxic side effects of INH. For example, about 2 percent of persons whotake INH develop hepatitis. The CPCRA is a network of primary care physicians and nurses who work with NIAIDstaff to design and conduct community-based clinical trials in patients with ...

Researchers Study 'Natural' Screen For Cancer

... who take these other substances can become photo toxic when in sunlight, for up to one month," explains Rawicz. "Hypericin actually has a 10 times higher phototoxicity -- but it lasts only 10hours." The researchers have run tests on dogs at a local veterinarian clinicand were able to detect one c...

BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference

...f toxicplatinum drug species and to produce a less toxic drug relative to otherprotecting agents. BioNumer... subjects pretreated with BNP7787prior to the same toxic dose of cisplatin. In addition to demonstrating safetyand efficacy in preclinical studies, BioNumer...

New Research In Battling Alzheimer's Impact On Memory

... may have found the first step in the formation of toxic plaquebelieved responsible for the destruction of ...r, slowlychanges into the insoluble plaque that is toxic to cells. The first step inthis process, which may be triggered by a changing biochemistry as one a...

Beware Of Adverse Drug Reactions

... prescribing doctors should always be aware of the toxic profile of the drugs they prescribe and that they should be ever vigilant for the occurrence of unexpected adverse reactions. Contact: Dr Munir Pirmohamed, Senior Lecturer in Clinical Pharmacology, Department of Pharmacology and Therapeutics, Univers...

Chemical Society's Highest Award Goes To Ronald Breslow

... "It's very difficult to make a selective toxic compound -- that is, achemotherapy drug that kills cancer cells without killing normal cells," hesaid. This is true largely because cancer comes not from foreign cells, "butfrom normal ones that are misbehaving. They've lost their balance, and we tr...

OHSU Scientists Begin Human Trials Of A Drug Aimed At The Underlying Cause Of Chronic Myelogenous Leukemia

...y to bringnew, more effective and potentially less toxic treatments to patients withserious illnesses. We need such highly targeted approaches for all patients withmalignant diseases." Hitting its victims in mid-life, CML arises when chromosomes 9 and 22exchange segments and form a faulty gene that...

The Problem With Fen-Phen

...e diet drug duo known as"fen-phen" was potentially toxic because the two drugs taken together destroythe body's ability to control the amount of serotonin in blood plasma. Too much serotonin damages blood vessels, particularly in the lungs, andmay also harm heart valves. Such damage may have led to...

University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence

...been a basic strategy -that's giving people a very toxic drug that's more toxic to cancer cells thannormal cells," Jordan said. "They are absolutely married to the fact thatthey'r...

Study Shows Potential For Quelling AIDS Nerve Pain

...comes fromeither the viral infection itself or the toxic effects of specific antiviraltreatments. "Nearly a third of people with AIDS have these neuropathies, mostoften affecting the legs and feet," says neurologist Justin McArthur, MBBS,M.P.H., "Patients may be in constant pain and many have difficulty w...

UCSF AIDS Expert Warns Against Early Treatment For HIV Infection

...s assumption, Levy says, is that these drugscan be toxic and can be directly detrimental to a natural immune response toHIV, which is present in most individuals even when they show no symptoms. Thiseffective antiviral immune response is characteristic of long-term survivors whohave been infected for more...

BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent

...that, in preclinical testing, BNP7787 appears less toxic than table salt, makingit non-toxic by pharmaceutical industry standards.BNP7787 is currently in Phase I clinical trials in the United States at theUniversity of Chicago Medical Center and the Roswell Park Cancer Institute inBuffalo, New York and in ...

Physicians Slow To Adopt Newer Drugs For Atrial Fibrillation

...rs that physicians react more quickly toreports of toxic reactions than they do to news of a medication'seffectiveness." Other authors of the Archives study are Daniel Singer, MD, Deborah Robson andBismruta Misra, MPH, of the MGH General Medicine Division; and Jeremy Ruskin,MD, of the MGH Cardiac Unit. Th...

WFU And IntraVec To Develop Innovative Cancer And HIV Treatments

...man patients, the scientists hope that the altered toxic cells willserve a continuing surveillance function... is less likelythan current drug therapies to have toxic side effects and generatedrug-resistant HIV mutants. Recent data indicate that the lifetime ...

Study Confirms Safety Of Common Heart Drug

...e than 20 percent of people taking the drug risked toxic reactions,including heart rhythm disturbances, nausea, vomiting, vision problems, andintestinal disorders. The researchers of one study pointed to a 41-percent deathrate among those who developed toxicity from the digitalis preparation. "Back in the...

Discovery May Boost Effectiveness Of Chemotherapy

...ne, a common first-line chemotherapy which is less toxic than manyother anti-cancer drugs. It is often prescribed for breast cancer, leukemia,colon cancer and myeloma. "With these findings, we may be able to make this gooddrug even better," says Dr. Ross. Mitoxantrone-resistant cell lines from bre...

UK Allied Health Professor Receives Patent On Using Lithium With AIDS Drugs

...rties andcould possibly protect certain cells from toxic therapies. Gallicchio proposesthat combining drug...S patients with lithium salts couldresult in fewer toxic side effects and reduce the amount of virus in a person'ssystem by enhancing the immune system. ...

Far Few Drugs Are Tested On Children

...ereincapable of clearing it from their bodies, and toxic levels quickly built up intheir bloodstream. Astonishingly, children still face similar risks today. The vastmajority of drugs have never been tested on children, forcing doctors toprescribe them "off label"-outside the conditions for which t...

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(Date:10/30/2014)... have to be at least 2 years old to ... no official U.S. guidance exists other than the general ... breastfeed for at least the first six months. , ... That,s the question that motivated researchers at the University ... study the eating patterns of American infants at 6 ...
(Date:10/30/2014)... A mathematical model developed by NIH grantees predicts that ... prevent HIV infection via vaginal sex, whereas just two ... via anal sex. This finding helps explain why two ... in women failed to show efficacy. Participants in the ... Truvada and tenofovir (another antiretroviral) for HIV prevention were ...
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