PCBs, fungicide open brain cells to Parkinson's assault
... many factors, such as the levels of exposure, the toxicities of individual chemicals present in any given mixture, and their interactive properties. Pesticides such as maneb remain in farmed soil for 20-75 days following application and can be found on produce for more than three weeks, even after washing, ac...Potential cure for lymphoma in HIV patients
... of the heart) and kidney failure due to treatment toxicities and died a few weeks after the transplant. Opportunistic infections, such as herpes zoster and cytomegalovirus infection, also occurred in a few Patients after the transplant, but were managed with appropriate therapy. Throughout the study, all Patie...New therapeutic vaccine for HIV/AIDS eliminates needles and excessive toxicity
...thus patients might be able to avoid the excessive toxicities of anti-HIV cocktails. According to the Joint United Nations Programme on HIV/AIDS, there are currently about 39.4 million people worldwide who are living with HIV/AIDS. Of that number, 4.9 million were newly infected with HIV just this year. Globa...Potentially fatal toxicities occur with off-label use of cancer drugs
...rs from informing patients about potentially fatal toxicities that occur with some cancer drugs -- policies that should be revised immediately, according to Northwestern University researchers. Andrew M. Evens, D.O., instructor in medicine, and Charles L. Bennett, M.D., professor of medicine, Northwestern Un...NIH halts use of COX-2 inhibitor in large cancer prevention trial
...caused a two-fold increased risk of cardiovascular toxicities in a trial to prevent adenomas. The APC is a study of more than 2,000 people who have had a precancerous growth (adenomatous polyp) removed. They were randomized to take either 200 mg of celecoxib twice a day, 400 mg of celecoxib twice a day, or a pl...New data sets survival benchmark for Pfizer's ELLENCE
...as heart damage or neutropenia. The most frequent toxicities reported in the study were hematologic. Grade 3-4 NCI-CTC hematologic toxicities included neutropenia (9.4% vs. 7.3%), febrile neutropenia (1.6% vs. 2.9%) and mucositis (0.8% vs. 1....Novel drugs help solve Gleevec resistance
...l dose has yet to be established as no significant toxicities have yet been encountered, more than 50 percent of patients with Gleevec-resistant CML have responded, including cytogenetic and molecular responses in some patients so far, Giles says. "While more study needs to be done to define a reasonable regime...Stanford to test effects of drug widely used for pediatric hypertension
... differently from adults. And drugs have different toxicities in neonates, infants, children and adults. Historically, companies avoided testing in pediatric populations either because they didn't want to risk injuring children or didn't want to risk finding out that drugs deemed safe and effective in adults we...Weekly cycles of once-daily anti-HIV drugs could reduce cost of HIV treatment
...edication, drug costs are reduced and drug-related toxicities may be less in the long run." He adds, "The 7-7 approach may have particular relevance to resource-poor countries around the world." Dr. Dybul, NIAID Director Anthony S. Fauci, M.D., and their colleagues report their findings in the June 1, 2004 issu...Molecular analyses of leukemia patients suggest strategies for better treatments
...s well as patients who are more susceptible to the toxicities of specific treatments. The new approach is also guiding development of new drugs that target specific cell molecules, thus avoiding the toxic side effects caused by chemotherapy. Clinical trials are underway to test the safety and efficacy of drug...Study examines physical, emotional well-being following breast cancer treatment
...l, oncology clinicians prepare women for the acute toxicities of breast cancer treatments, but clinicians have had only limited data on the physical and psychosocial sequelae of primary treatments," writes lead author Patricia A. Ganz, M.D., of the University of California at Los Angeles Jonsson Comprehensive...Major advance in chemotherapy in breast cancer
...AC. There were no toxic deaths and no long-lasting toxicities with either treatment arm. "These results offer a promising new treatment option for reducing the risk of recurrence and mortality of early breast cancer patients," said Susan Braun, president and chief executive officer of the Susan G. Komen Breast ...Updated data compares DOXIL (R)/CAELYX (TM) (doxorubicin HCl liposome injection) to Topotecan
...ted in either treatment group. Severe hematologic toxicities for DOXIL and topotecan, respectively, included neutropenia (an abnormal decrease in the number of neutrophils, a type of white blood cell; 35 percent vs. 81 percent), anemia (reduced red blood cell count; 35 percent vs. 72 percent), thrombocytopenia...New weapon may help flush stealth stashes of HIV in cells
...evious studies have demonstrated that there are no toxicities associated with Peptide T....UB begins groundbreaking study on 'net effect' on patients of HIV treatments, other drugs
... also is aimed at uncovering some of the long-term toxicities from these drugs, which are becoming an increasing concern because people are living longer with HIV infection....Other highlights in the September 3 issue of JNCI
...lower frequency of gastrointestinal and neurologic toxicities and better quality-of-life scores than the cisplatin-paclitaxel regimen. The authors conclude that the carboplatin-paclitaxel regimen should be considered as an alternative for first-line therapy in ovarian cancer patients. Association Found Between......tem cell donor pool, decreasing transplant-related toxicities and investigating its use in diseases not commonly treated with stem cell transplantation. October 21, 2003 When Too Much Iron Is Bad: Hemochromatosis, the Silent Blood Disease Susan Leitman, M.D., Acting Chief, Transfusion Medicine, NIH Clinical C...Paclitaxel combination improves survival from small-cell lung cancer
...sion-free survival, and a decrease in drug-related toxicities for patients with SCLC on a paclitaxel-containing regimen compared with standard chemotherapy," the authors write. "The three-drug combination of paclitaxel, etoposide, and carboplatin was effective, safe, and well-tolerated, and therefore we conclud...Tipsheet on XIV International AIDS Conference
...ens, but not better than ZDV+3TC+EFV. Significant toxicities were greater in arms containing d4T in combination with ddI than in those containing ZDV and 3TC. The initial observations indicate that ZDV+3TC+EFV is a particularly useful regimen for initiating therapy in HIV-infected individuals who have not prev...New treatment reduces liver tumors and improves quality of life for cancer patients
...eated with TheraSphere exhibited radiation-induced toxicities outside of the liver resulting in improved quality of life for patients undergoing the treatment. TheraSphere is an outpatient procedure that lasts from 30 to 40 minutes. The glass beads are delivered by catheter into the femoral artery up through t...