Steroid pill prolongs survival in patients with multiple myeloma
..., was effective as maintenance therapy without the toxicities and costs associated with interferon, said Dr. Berenson. In the study, the researchers compared patients with multiple myeloma receiving prednisone in pill-form following a response to treatment with one of two chemotherapy combinations: vincristine......llent safety profile. There were no dose-limiting toxicities in the patients treated with MARstem. Specifically, there were no adverse cardiovascular or hematologic effects. The overall occurrence of side effects was lower in MARstem patients than in control patients. The 11th Annual NCI-EORTC-AACR sympos...Bristol-Meyers Squibb submits NDA for new formulation of once daily videx(R)(didanosine)
...anosine and other antiretrovirals. Other important toxicities include retinal changes, optic neuritis and peripheralneuropathy. Patients treated with VIDEX in combination with stavudine, with or withouthydroxyurea, may be at increased risk for adverse events such as pancreatitis, peripheral neuropathy and live......ies remains a high priorityto assess any late drug toxicities as well as long-term survival. The mothersand their children will continue to be actively followed until the babies are 18months old. This period is critical to establish the efficacy of theintervention because even if a baby is born HIV-free, he o......e therapeutic index and protect against the common toxicities ofwidely used anticancer drugs, including taxane and platinum based agents. BioNumerik's karenitecin is a novel silicon-containing anticancer compound thathas demonstrated potent antitumor activity at concentrations as low as parts pertrillion in la...UCSF Recruting Breast Cancer Patients For Herbal Therapy Study
...hemotherapy. In addition, thetrial will assess any toxicities associated with the use of the formula inconjunction with chemotherapy. After conferring with many herbalists around the world, studying past clinicaltrials of herbal therapies, and reading text books on the subject, UCSFresearchers developed a formu......num-associated drugtoxicities for newly-introduced toxicities of their own. The Seminars in Oncology paper, tit...n-induced kidney toxicity,vomiting and bone marrow toxicities while increasing cisplatin's antitumoractivity. In these studies, tumor bearing animals receiving B...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...hed in alarger group of patients. The fact that no toxicities were reported in caseswhere the virus has been injected into adjacent normal tissue is particularlynoteworthy, they said. "We are encouraged by the 30 percent overall regression rate we have seen todate in a group of patients that has failed al......e effects. Significant neurologic, kidney orliver toxicities were rare in both groups. The mechanism of suramin's action is complex, said Small, and still has not beenfully delineated. Prostate cancer, the most common cancer in men, accounted for more than 40,000deaths in the United States in 1997. Approxim......BNP7787 appears to completelyprotect against major toxicities associated with widely used platinum anticancerdru...s to substantially protect against the commonmajor toxicities of platinum chemotherapy and does not interfere with theantitumor activity of cisplatin. There app...