A Good Night's Sleep Is Possible At High Altitudes
... altitude: randomised placebo controlled crossover trial Poor sleep in people who have recently arrived at high altitude is common and may lead to daytime symptoms of drowsiness and reduced performance. Until recently, medical advice has been to avoid using sedatives at altitude, as they might provoke ...Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors
...ecently approved by the FDA for a Phase I clinical trial at the University of Pennsylvania Medical Center. Patients with early stage cervix tumors, located at the neck of the uterus, and soft tissue sarcomas, are given EF5 intravenously two days before their tumors are surgically removed or biops...Research Trial To Test New Drug For Diabetic Neuropathy
Hershey, Pa. --- A multi-center clinical research trial is underway to test a new drug to treat diabetic ...rug is working," says Simmons. "If this phase two trial shows promising results regarding nerve conduction velocities, we would likely move to a phase thr...Four-Year Study Shows Long-Term Effectiveness Of Proscar In Treating Enlarged Prostates
...t requiringcatheterization. "This clinical trial demonstrates that finasteride clearlyalters the progression of BPH," said McConnell, holder of the E.E.Fogelson and Greer Garson Fogelson Distinguished Chair in Urology."The most significant finding of this study is the dramatic decreasein the number......d pressure and non-insulin dependentdiabetes. The trial compared an ACE-inhibitor with a calcium antagonist in theprevention and progression of diabetes in equal number of individuals. Asecondary goal of the study was to determine if the drugs could preventcardiovascular disease, a leading cause of death...Tighter Chemical Binding = Better Meds
... "Historically, drug development has been largely trial and error.To improve a drug meant making a very large number of modified compoundsand laboriously testing each one," Jorgensen said. "Part of the hope withrational drug design and computers is to narrow the search, to pinpointthe modifications that ...Clinical Pharmacists Improve Outcomes Of Heart Failure Patients
...rchers said. "This is the first randomized trial to measure the effects of a clinicalpharmacist in the management of heart failure patients," said clinicalpharmacist Wendy Gattis, who has a doctorate in pharmacy. "These patients have achronic disease that can be managed with appropriate medications...... perceived benefits of the drug beingtested in one trial and decreased the perceived benefits of the drug i... "It is very important for us involved in clinical trial design tounderstand why such significant differences between the physicians and thecommittees exist,...Increased Public Access To Defibrillation Could Prove Potentially Cost-Effective And Life-Saving
...ally attractive. They call for a thoroughclinical trial to assess the effectiveness and cost-effectiveness of PAD. In addition, they say that AEDs should be distributed at specific siteswhere people often go into cardiac arrest, such as public places where there arelarge numbers of people -- airpo...Fat: It's Not For Breakfast Anymore; Study Finds Fat Linked To Clotting
...akfasts," according to Mennen. "The results of our trial support the viewthat the factor VIIa response to a high dietary fat intake is independent of thetype of fat," says Mennen, who adds that this response would probably occurafter any fat-rich meal, not just breakfast. He stresses that there is ......empt to prevent chronic lung disease. The trial tested whether giving the drug to premature infants on aventilator at two weeks of age was more effective than waiting until four weeksof age. Babies were randomized to one of two groups: the first group started atwo-week course of dexamethasone tre...(Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India) Bihar in north east India accounts for half the annual worldwide cases of visceral leishmaniasis (a disease transmitted by sandfly bit...Studies Look At Threshold Effect Of Cholesterol-Lowering "Statin" Drugs
...rugs," headvises. "A delay in drug treatment for a trial of dietary therapy in suchpatients is not necessary nor warranted." It may take more research to answer the questions about what are the upperlimits of benefit for statins. In the meantime, physicians need to make surepatients who need the drugs are...Widely Used Therapy May Not Be Effective In Treatment Of Acute Stroke
...ients, according to the results of a largeclinical trial published in the April 22, 1998, issue of The Jour...ogical Disorders and Stroke(NINDS), is the largest trial of an intravenously administered anticoagulantdrug for treatment of acute ischemic stroke. The purpo...Cost-Effective Treatment Possible In Africa For HIV-Positive Pregnant Women If Drug Prices Lowered
...enters forDisease Control and Prevention-sponsored trial in Thailand have shown that ashort-course of the antiviral drug AZT alone can cut vertical transmission byabout half," he added. Glaxo Wellcome also has announced its plan to reduce AZT prices for verticaltransmission prevention in low-income count...Secondary Prevention Of Heart Disease Should Be Improved
...ion clinics for coronary heart disease: randomised trial of effect on health) In two General Practice papers in this week's BMJ, Dr Neil Campbell et al from the University of Aberdeen find that secondary prevention for coronary heart disease could be improved within general practice and that where clinic...... suramin plus hydrocortisone group." The clinical trial was "double-blind," meaning neither physicians nor patientsknew who was receiving which drug combination, and patients were assigned one ofthe two treatments randomly. All patients had metastatic prostate cancer, and were no longer responsive toconv...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...iated the Phase II, single agent intensive regimen trial in March ofthis year. All of the Phase II studies of ONYX-015 in head and neck cancer areexpected to be completed before the end of 1998. At that time,the company will evaluate the full complement of data and determine the nextstep in clinical deve......paclitaxel/carboplatin tocisplatin/etoposide. The trial enrolled 369 patients with advanced ormetastatic NSCLC between May 1995 and July 1996. One hundred seventy-ninepatients received cisplatin/etoposide and 190 received paclitaxel/carboplatin. After initial therapy, patients could receive additional ch...