Elderly cancer patients are significantly under-represented in cancer clinical trials
...inical trials, the treatments resulting from those trials may not be appropriate for them," said Lilia Talar...ysis of 28,766 people participating in 55 clinical trials of new cancer drugs or new indications of already approved cancer drugs from 1995 to 2002. Data on...Encouraging results from vaccine trial to reduce cervical cancer
...ide rates of cervical cancer. However, large-scale trials with long-term follow-up are needed to extend our findings and confirm that vaccination prevents cervical cancer." In an accompanying commentary (p 1731), Matti Lehtinen and Jorma Paavonen (University of Helsinki, Finland) state: "Licensure of the H...Marine sponge leads researchers to immune system regulator
...lCer or KRN 7000, is now in phase-2 human clinical trials for several tumor types. One problem with a-GalCer, however, is that it can over-stimulate NKT cells. After a burst of activity and rapid secretion of interferon-gamma, NKT cells driven by a-GalCer essentially "burn out," disappearing from the circ...Cholesterol-lowering drug may also reduce risk of blood clots
...ious side effects," said Brey. "However, clinical trials must be performed to see if their protective effect in patients with aPL holds up." ...High doses of vitamin E supplements do more harm than good
...e. They studied death rates in published clinical trials comparing vitamin E supplementation to placebo and...in fact, in seven of the eight high-dose vitamin E trials in this analysis) the patients on vitamin E supplementation were more likely to die than those in th...Morphine for chest pain increases death risk
...essions in New Orleans. "Since randomized clinical trials evaluating the safety or effectiveness of morphine for these patients have not been conducted, official guidelines for its use are based solely on expert conjecture," Meine continued. "Given the adverse outcomes associated with morphine use found in ...Study shows high-dose vitamin E supplements may increase risk of dying
...om 1.4 years to 8.2 years. When the data for these trials was re-evaluated, through a process called a meta-analysis, nine of 11 trials involving high-dose vitamin E (400 IU per day, or more) showed an increased risk of death. The othe...Drug-eluting stents adopted quickly, with early disparities
...ld be seen more as an impetus for further clinical trials rather than an immediate safety issue, since cardi...of scar tissue inside the artery. So far, clinical trials have shown that these new stents can reduce the restenosis rate to single digits from the 20 to 30 p...Following heart care guidelines saves lives
...The guidelines, adopted after large-scale clinical trials demonstrated the effectiveness of specific therapies in saving lives, focus on giving suspected heart attack patients anti-platelet medications, heparin, glycoprotein IIb/IIIa inhibitors (clot inhibitors) or beta-blockers within the first 24 hours of...USF neuroscientists awarded $1.1 million NIH grant to improve Alzheimer's vaccine
...ome Alzheimer's patients participating in clinical trials of the vaccine fell ill with brain inflammation. The researchers hypothesize that the combination treatment may have "super-additive effects" in removing Alzheimer's-associated plaques from the brain, while protecting the brain from the side effe...Controversies regarding ovarian cancer treatments addressed
...ing similar mistakes in developing future clinical trials and suggests that this review could be an additional source of reference for policy-makers. ...Limitations of current evaluation techniques for the cost-effectiveness of treatments
...ng PD interventions. However, since most clinical trials are short, mathematical models must be used to link the short-term clinical outcomes from clinical trials with evidence for the long-term progression of the disease. PD is particularly complex because of t...Cholesterol-lowering drug may slow Alzheimer's progression
...er than one alone. There are larger, multi-center trials in progress to confirm these findings." Co-authors are Marwan N. Sabbagh, M.D., Donald J. Connor, Ph.D., Lenore J. Launer, Ph.D., Suzana Petanceska, Leslie Baxter, Patrick Browne, M.D., Jean Lopez, R.N., MSN., Dawn Wassar Pharm. D., Jeff Lochhead M.S...Rare heart problem decreases in clot-busting era
...linical data from seven multi-center international trials designed to evaluate different fibrinolytic agents...d to unconsciousness and death. The seven clinical trials from which data was drawn were GUSTO-I, GUSTO-IIb, GUSTO-III, ASSENT-II and ASSENT-III, ASSENT-III P...African-American heart attack patients fare worse long term
...led data from five different multi-center clinical trials of fibrinolytic, or clot-busting, agents. Of the 3...ent participation rate of African-Americans in the trials from which the data was drawn is consistent with the historical range of 2 percent to 9 percent Afri...Taking pills, even if placebo, predicts better survival in heart failure
...and Morbidity (CHARM), was one of the largest such trials and had an average patient follow-up of 38 months. Adherence was measured as the proportion of time patients took at least 80 percent of the study medication. Two earlier heart studies the Coronary Drug Project in 1980 Beta-Blockers in Heart Attack ...Stem cell therapy effectively treats heart attacks in animals
...on. If further animal studies and human clinical trials prove equally successful, the Hopkins researchers believe this could be a new, widely applicable treatment to repair and reverse the damage done to heart muscle that has been infarcted, or destroyed, after losing its blood supply. Nearly 8 million A...Reduced risk of institutionalisation in patients with dementia
... the three randomised, placebo-controlled clinical trials of galantamine and their subsequent open label follow-up studies (3-4 years) 2,3,4. This data was supplemented with data collected retrospectively on former trial patients in 2004. All patients lived at home at entry into the clinical trials, and som...No increase in deaths for heart failure patients with pulmonary artery catheter
...eing presented today in the late-breaking clinical trials section of the American Heart Association's Scientific Sessions 2004. "Heart failure affects about 5 million Americans and the numbers are growing. So it is important to find out the best way to diagnose and treat this serious condition. The ESC...St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
...ctive treatments in the limited number of clinical trials that can be conducted for any given type of childhood cancer. The PPTP will begin testing agents in early 2005. "This is the first attempt to evaluate new drugs or biologics in a consistent manner to select those agents ...