First US SARS vaccine trial opens at NIH
... that this virus existed. Today, we begin clinical trials of a promising vaccine candidate. We owe the speed of this research to modern molecular genetics. The technology enables us rapidly to translate scientific discoveries into clinical interventions and improves our ability to battle these ever-evolving...Shire receives US FDA approval of EQUETRO (TM) for bipolar disorder
...M.D., primary investigator of two EQUETRO clinical trials comments: "The approval of the extended-release carbamazepine capsule, EQUETRO(TM), with an improved tolerability profile allows for a more rapid dosage titration that should provide physicians with a powerful new treatment option. EQUETRO demonstra...Re-analysis of large trials shows greatest benefit of chemotherapy in ER-negative tumors
...t had been treated with tamoxifen, and none of the trials showed a statistically significant benefit for higher doses of chemotherapy in ER-positive patients." Berry says that the results will likely surprise oncologists "because everyone has assumed that ER status doesn't matter in chemotherapy treatment,...Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
...nd medical records from women enrolled in clinical trials of the cancer drug tamoxifen, which blocks the effect of estrogen on breast cancer cells. These women had a kind of breast cancer defined as estrogen receptor-positive, lymph node-negative. Each year, over 50,000 women are diagnosed with this kind ...Scientists turn on the 'gender lens' on cardiovascular disease research
... on assessing epidemiological studies and clinical trials inthese two important problem areas," said Dr. Anand. "We will be analyzingdata with a gender lens, asking questions such as 'Is it appropriate thatwomen with heart disease receive fewer angiograms, compared to men?'" Another emphasis for the networ...NIAID-sponsored clinical trial aims to boost flu vaccine supply
...n Units (VTEUs) are structured to perform clinical trials efficiently, enabling us to get needed information rapidly." "Although the vaccine we are testing has a very long safety record in Europe and other parts of the world, the type of study we are conducting must be done before the vaccine can be licens...Scientists stalk PPAR-gamma, find novel cancer connection
...ugs work against multiple myeloma, before clinical trials are warranted." Each year doctors diagnose about 14,000 people in the United States with multiple myeloma, which accounts for about 10 percent of the blood cancers. Myeloma is characterized by an abnormal number of white blood cells called pl...Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
...ths. The next step, Dr. Dietzschold says, is field trials of the vaccine. In such trials, animals would be given food baits with vaccine, then later captured and tested for rabies antibodies. He notes that some 70 percent of an animal population in an area needs to have sufficient antibodies to control the ...Research gets to heart of advertising gender bias
...o increase female representation in cardiovascular trials are ongoing, the vast majority of scientific evidence is based on men," says Cheung. This study appears in the November issue of the Journal of Evaluation in Clinical Practice....Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
...o translate these laboratory studies into clinical trials in patients with GBM." GBM tumors develop in t...get of a number of laboratory studies and clinical trials investigating the effectiveness of gene therapy to deliver novel therapeutic agents to the brain. M...New marrow transplant method developed at Stanford may eliminate fatal side effects
...f Hematology meeting in San Diego. In two clinical trials funded by the National Institutes of Health, Lowsk...ut is now being accepted and adapted into clinical trials as a conceptual framework for achieving certain desirable outcomes, for example in the area of bone ...Novel drugs help solve Gleevec resistance
... compounds, undertook independent Phase I clinical trials of both agents. It conducted the study of BMS-354825 in conjunction with the University of California, Los Angeles, and the study of AMN107 with the University of Frankfurt, in Germany. The M. D. Anderson researchers will discuss their experiences us...November/December 2004 Annals of Family Medicine tip sheet
...icians; however, a systematic review of 35 medical trials found that there is little research that measures the effectiveness of specific interventions and approaches on health outcomes. Bag of Worms By James L. Glazer, M.D. A family physician describes his experience as a resident physician...Endocrine Society calls for clinical guidelines on androgens for women
... --Androgen Therapy in Women-- Several clinical trials have already examined the efficacy of androgen therapy in women. Preliminary results suggest that this treatment is effective in certain women, primarily when testosterone is administered at doses that raise free testosterone to the upper limits of ...Establishing pediatric stroke trials
... translation research experience in adult stroke trials sickle cell disease prior experience in trials with children trial design and pitfalls Faculty: Hosted by Steven Pavlakis, MD, Director of Ped...Stem cells of limited use for cardiac muscle repair
...orking skeletal or cardiac muscle cells. Clinical trials of this approach are already underway in patients who have had a heart attack and initial results have been "promising." Despite high hopes for such cellular self-renewal, however, many researchers remained skeptical about the capacity of adult st...Virtual colonoscopy shows significant promise as colorectal cancer screening option
...task force reviewed the results of recent clinical trials and quantitative mathematical models pertaining to...nography included variation in results of clinical trials and limited data on its use in routine clinical practice. One limitation of CT colonography is that...NIAID seeks applicants to lead revamped HIV/AIDS clinical trials networks
...ced that it is restructuring its HIV/AIDS clinical trials networks and soliciting investigators and institutions to lead the reorganized effort. This reorganization, designed in response to both the changing face of the AIDS epidemic and evolving scientific challenges, will enable NIAID and its many collabo...Some harms of beta-carotene supplementation may persist after discontinuing use
...hemopreventive abilities, so two large, randomized trials were begun to test the supplement's effect on lung...T), which was conducted in the United States. Both trials were stopped after evidence accumulated that the supplements were associated with an increased risk ...Study finds continued reduction in breast cancer incidence associated with longer use of raloxifene
...s, but write that the results of the CORE and MORE trials support the conclusion that raloxifene reduces the...the results of several large-scale chemoprevention trials will help clarify the role of raloxifene, as well as other hormonal agents, for breast cancer preven...