Researchers discover new clinical syndrome leading to severe osteoarthritis
...kdown and forms of osteoarthritis. The researchers uncovered two mutations involving the FRZB ("frisbee") gene located on chromosome 2, which has been implicated in familial osteoarthritis. In previous laboratory studies done elsewhere, FRZB appears to be important in the development of human limbs at a young...Delayed care may affect prostate cancer deaths in blacks
...e the regular or high-quality care that would have uncovered those illnesses....Study: New neurons can get out of spinal cord
...inside. Fortunately, other scientists had recently uncovered molecules that can block myelin's axon-repelling effect. So the team implanted the rats with a pump to drip these myelin "de-squelchers" in the vicinity of the animals' spinal cords. As a result, some motor neurons extended themselves through the cor...Prescription of opioids for back pain needs improvement
...ve the patterns and trends in opioid use they have uncovered could provide a rational scientific basis for future investigation of safety and effectiveness of these drugs in the U.S. "The wide variations in the use of opioids suggest that there is a definite need to improve prescribing patterns for patients wi...Longevity gene may also predict better outcome for breast cancer patients
... protein that can induce cancer. "We have uncovered two important events and put them together in one story," says Hung. "This research has identified an important new tumor suppressor protein and a new oncogene that provide targets for cancer therapy. Previously, these proteins had been suspected to ...Making music could be bad for your skin
...t these conditions. Many of the reports Gambichler uncovered described cases of "fiddler's neck". This is a chronic irritant condition where an area of skin on the side of the neck that is in contact with the violin or viola becomes thicker than normal, and discoloured giving it a leathery, bark-like appearan...Hopkins' young researchers honored for their contributions
...able. With the system he developed, however, Jiang uncovered the first link between the cell cycle (the steps c...ght regulates the mammalian internal clock. Hattar uncovered a third class of cells in the retina that detect light, ending the monopoly of rods and cones, which...Jefferson researchers discover novel gene profile that may identify colon stem cells
Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny "crypts" in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the developm...Key to proper blood vessel growth in eye and ear discovered
...ard Hughes Medical Institute at Johns Hopkins have uncovered the first cue to the carefully choreographed growth of tiny blood vessels in the eye and ear. Their report, in the March 19 issue of Cell , will help improve understanding of major eye diseases, most of which stem from abnormal blood vessel growth i...Childhood abuse may predict social phobia, agoraphobia, and PTSD among adult alcoholics
...Alcoholism: Clinical & Experimental Research have uncovered the important role that an environment of childhood abuse sexual, physical or both appears to play in the development of psychiatric comorbidity among alcoholic patients. "Our findings clearly indicate that childhood abuse more specifically, sexua...Progenitor cells predict heart disease severity
...-- Duke University Medical Center researchers have uncovered a strong relationship between the severity of heart disease and the level of endothelial progenitor cells circulating in the bloodstream. This relationship, if confirmed by ongoing studies, could represent an important new diagnostic and therapeutic ...Widely used anti-nausea drug may interfere with cancer chemotherapy
... careful search of the literature on dexamethasone uncovered another surprise. "Remarkably," the authors note, no clinical studies had ever addressed the potential effects on tumor response of administering Dex before routine chemotherapy for breast cancer. To study these effects at the molecular level, Conze...Study shows women's medication use higher than expected
...ons. Researchers found that every set of questions uncovered additional medications patients didn't initially report. They also discovered that while a patient may report that she's taking a medication during the first visit's interview, she failed to mention it on subsequent visits without prompting. The inte...Pain may interfere with depression improvement
...merly of the Regenstrief Institute, and colleagues uncovered the connection by analyzing the results of a clinical trial of 573 depression patients taking medications like Prozac, Paxil or Zoloft. Their findings are published in the journal Psychosomatic Medicine. Although depression improved in most of the...First US tuberculosis vaccine trial in 60 years begins
... awarded in the late 1990s supported research that uncovered the most effective adjuvant-protein combination. NIAID's TB program officer, Christine Sizemore, Ph.D., notes, "This clinical trial is a wonderful example of advances made possible through sustained support and creative use of resources in NIAID's TB...Heavy smokers see cigarettes as 'friends'
...smokers in the journal Nicotine & Tobacco Research uncovered both anger and fear at the thought of quitting, say Beti Thompson, Ph.D., and colleagues of the Fred Hutchinson Cancer Research Center. "Over 90 percent believed that even though smoking was dangerous, it was their 'friend.' The danger of losing a...A pair of discoveries helps unravel complex genetics of inflammatory bowel disease
...A major clue that NFKB1 may be involved in IBD was uncovered when it was shown that NFKB1 seems to be responsible for mice genetically predisposed to developing colitis, says Brant. The team searched the DNA of 235 families with IBD (from Johns Hopkins, the University of Chicago and the University of Pittsburg...Researchers find additional families with gene linked to gout and kidney failure
...t." He said that the Wake Forest team already has uncovered the disease in more than 40 members of a Western North Carolina family the initial group that has been traced back to 1785. The team has studied the family for more than six years. "We are currently interested in studying individuals who developed...Jefferson and Michigan scientists identify gene defect behind muscle-wasting disease
...edical College and the University of Michigan have uncovered a gene defect responsible for a muscle-wasting, neurodegenerative disease in mice known as mnd2. Their results may provide insights into the molecular origins of other such diseases in humans, including Parkinson's disease. In an online report on Oct......he microbiologist at New York University who first uncovered the link between tampons and toxic shock syndrome, disputes the team's claims. "The reason most patients do not develop antibodies is because the toxin prevents antibody formation," he says. TSST-1 is a superantigen, meaning that high levels can tri...