Tag: "variant" at medical news

New research on Tourette's syndrome

... suppressthese impulses. "It's probably an extreme variant of a normal thing felt by manypeople," he says. "It's a nice observation," says John Rothwell, an expert on movementdisorders at the Institute of Neurology in London. "It may tell us somethingabout how the brain makes normal voluntary movemen...

Southeast appears to have a unique type of Lyme disease

...stern United States seems to be due to genetically variant strains of the spirochete Borrelia burgdorferi," Dr. Felz said. "These strains probably have a different DNA backbone and cause different clinical symptoms and signs than is the case in other parts of the country." Dr. Felz, who has studied ticks a...

Gene variant increases heart disease risk, even when cholesterol is normal

...eart attack or stroke. To determine if the apoE-4 variant was associated with heart disease, Scuteri and his...milar to the original finding that the apoE-4 gene variant significantly increases an individual's risk of heart disease. "Prior studies suggested that the ma...

Specifying alcohol-related brain damage in young women

...coholism: Clinical & Experimental Research uses a variant of magnetic resonance imaging (MRI) to closely examine brain function in young alcoholic women. "Previous studies have shown that alcoholic women perform just as poorly as alcoholic men on thinking and memory tests," said Susan F. Tapert, first a...

Fever immediately after heart bypass surgery associated with cognitive decline

...c component to the decline. Patients with the E-4 variant of the APOE gene (which has also been linked to early onset Alzheimer's disease) tend to do worse than patients with other variants of the gene....

Novel colorectal cancer trial seeking patient volunteers at leading U.S. cancer centers

...ne responses for cancer immunotherapy. Alvac is a variant of the canarypox virus that produces a self-limiting infection that does not cause any harm or symptoms in humans, but causes infected cells to temporarily display tumor-associated antigens (TAA) linked to specific cancers. In response to these TAAs...

Genetic test for cell-proliferation enzyme could improve treatment of acute lymphoblastic leukaemia

...s investigated the possible association between a variant of the gene coding for thymidylate synthase(in which a specific triple repeat alteration is associated with increased expression of thymidylate synthase) and the outcome of acute lymphoblastic leukaemia in 205 children treated with methotrexate. DNA...

Gene enhances effects of estrogen on good cholesterol

WINSTON-SALEM, N.C. A genetic variant seems to determine how well womens good cholestero...ngton. We also need to know if women with the gene variant are more sensitive to estrogens other effects. But, this finding is exciting because it shows the po...

Genetic tests could define us all as patients

...eneficial. Unless it is established that a genetic variant is a pointer to beneficial action, there is a potential for inappropriate medicalisation through the spread of poorly understood tests, say the authors. The perceptions of risk resulting from such tests may bear little relation to the scientific fact...

Calcium channel gene may play a role in severity of neurodegenerative brain disease

...o a large Founder effect or where a specific gene variant is concentrated in a particular population. Two groups of patients were then chosen based on being above or below the average age for developing the disease. The first group was comprised of 33 patients who developed SCA2 at a much later age, whil...

Statin drugs may lower risk of Alzheimers

...zheimers was no different for people with the gene variant associated with an increased risk of Alzheimers, apolipoprotein E ?4, or apoE-?4. The relationship between statins and Alzheimers was also the same for whites as it was for African Americans, who have a higher risk of developing the disease. Statins ...

Genetic abnormality may increase stroke risk fourfold among young

...orphism. However, the paraoxonase 192 polymorphic variant occurred significantly more often in the stroke pa...rs, the researchers found that presence of the 192 variant increased stroke risk by a factor of 4.10 compared to absence of the genetic abnormality. This parti...

Clinical symptoms may aid early diagnosis of variant CJD

The possibility of a large epidemic of variant Creutzfeldt-Jakob disease cannot be excluded, and ...the early psychiatric and neurological features of variant Creutzfeldt-Jakob disease to aid early recognition of this condition. Researchers analysed the case ...

Vaccination delays onset of prion brain disease in mice

...et a number of different prion diseases, including variant Creutzfeldt-Jakob disease (vCJD). T...tion. In England more than 100 people have died of variant Creutzfeldt-Jakob disease in recent years because they allegedly ate scrapie-contaminated beef (catt...

Genetic variant reduces immune response, yet protects against atherosclerosis

...l Center researchers has discovered that a genetic variant of an immune system receptor appears to simultaneously dampen the body's immune response to bacteria and other microbial toxins and to provide some protection against atherosclerosis, or clogging of the arteries. The scientists believe their discover...

When moms smoke, certain kids are more vulnerable

...of Medicine of USC. Children with a common genetic variant who were exposed to maternal cigarette smoke in th...than 45 percent of all children had the GSTM1 null variant genotype. When researchers looked only at children with the GSTM1 null genotype, they found that in ...

Urgent need for more research into prevalence of CJD

...d at autopsy or during surgery from patients with variant Creutzfeldt-Jakob disease. The samples were tested for lymphoreticular accumulation of prion protein, which is known to be a reliable marker of the disease in animals. Prion protein was detected in one of the 8318 samples removed between 1995 and 199...

Larger blood reserves needed for ageing population

...specially as the introduction of donor testing for variant Creutzfeldt-Jakob disease could have a major impact on the numbers of blood donors, with estimates that up to 50% of active donors could be lost. Small increases in the number of elderly people will have large effects on demand, add the authors. Effo...

Genetic variant may impact smoking cessation

...Philadelphia, PA) Smokers with a specific genetic variant may be more vulnerable to cigarette cravings and r... found that participants with a decreased activity variant of the CYP2B6 gene reported greater increases in cravings for cigarettes following the quit date and...

Genotyping targets individuals at high risk for H. pylori-associated stomach cancer

... infected by an H. pylori strain with a particular variant of the vacA vacuolating cytotoxin had a nearly 90-fold increase in the risk of stomach cancer. "Our findings indicate that H. pylori and host genotyping can be important in better defining disease risk and preferentially targeting H. pylori eradicat...

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