Fred Hutchinson oversees two grants of nearly $8 million to develop blood test for breast cancer
...to survive. Growth factors to be evaluated include vascular endothelial growth factor, or VEGF, which is associated with 80 percent of breast tumors and is an indicator of poor prognosis among women with estrogen-sensitive tumors; lipid markers, or fatty acids, detectable in serum or plasma, which are associ...Cholesterol-lowering drugs safe and effective in children
...author Saskia de Jongh, M.D., of the department of vascular medicine and Emma Children's Hospital of the Academic Medical Center at the University of Amsterdam in the Netherlands. Inherited high cholesterol, known as heterozygous familial hypercholesterolemia (heFH), is common and caused by mutations in the ...In blood pressure reduction, below standard is good
... of Medicine, Toyko. Researchers used a measure of vascular stiffness called pulse wave velocity (PWV) to determine if lowering blood pressure using antihypertensive drug treatment would affect aortic stiffness in nondiabetic patients who had high blood pressure. PWV is a velocity measurement, calculated by ...Elevated leptin in teens linked with dangerous artery changes
... on the role of leptin in the development of early vascular disease and suggests a physiological link between vascular disease and obesity, says lead researcher Atul Singhal, M.D., deputy director of nutrition at the MR...New drug may help recovering cocaine addicts, study shows
...e use causes many medical complications, including vascular occlusions that cause disturbances in heart rhythm and heart attacks; chest pain and respiratory failure; strokes, seizure, and headaches; and abdominal pain and nausea, according to the National Institute on Drug Abuse, which funded this research. I...Gene therapy promising for preventing restenosis
...lial damage causes a decrease in concentrations of vascular superoxide dismutase or SOD, an enzyme that works inside and outside cells as a powerful antioxidant to control levels of free radicals. Yla-Herttuala and his colleagues theorized that by injecting the gene for extra cellular superoxide dismutase (E...Cognitive decline after cardiac valve replacement not a given
...comes through general medical care and by reducing vascular risk factors following their CAGB, said Mllges. "M...k with their patients to provide care that reduces vascular risk for myocardial infarction, stroke and vascular dementia and contributes to a better quality of...Skin test may detect subarachnoid hemorrhage risk
...patients with cervical artery dissections, another vascular defect that causes stroke. They initiated this study because dissections and aneurysms might be related, they say. Biopsies from the arterial wall of patients are rarely available, Grond-Ginsbach explains. Skin is considered a window to heritable ...Other highlights in the September 4 issue of JNCI
...ic stimulants (fibroblast growth factor-2 [FGF-2], vascular endothelial growth factor-A, or angiopoietin 2). They also noted that GcMAF inhibited angiogenesis induced by fibroblast growth factor-2 in vivo . By using monoclonal antibodies against CD36, a receptor for the antiangiogenic factor thrombospondin-...Popular long-acting contraceptive linked to vascular dysfunction
...their physician." Pennell and colleagues measured vascular function in women who used DMPA for at least a yea...hose of women who didn't use DMPA. They evaluated vascular function by measuring changes in the brachial artery (the artery in the arm where blood pressure is ...Transplants in HIV patients should proceed, but drug interactions a concern
...transplants. One patient studied lost his graft to vascular rejection because a drug interaction with one of the medications in the HAART therapy made it difficult to achieve therapeutic levels of the anti-rejection drugs. According to Dr. Anil Kumar, more than one year after transplantation, 17 patients are ...Blocking pathway overcomes tumor vessel resistance to radiation
...ssels more resistant to therapy. "We know that if vascular endothelium is destroyed, tumor control can be improved," said principal investigator Dr. Dennis Hallahan, chairman of Radiation Oncology. "However, the blood vessels are often resistant to the therapy. Our initial hypothesis was that the cell surviv...New endovascular prosthesis is promising for non-surgical treatment of TAAs
...threatening condition caused by a weakening of the vascular wall of the aorta in the chest, TAAs can lead to either sudden death or death in a matter of hours if the aorta ruptures. In an REI clinical study, Dr. White and a team of cardiovascular surgeons, radiologists and scientists have successfully treat...Dementia before or after stroke increases risk of death
... and functioning. This type of dementia is called vascular dementia and has been associated with stroke. In ...3 of the 75 patients with post-stroke dementia had vascular dementia, while 12 had "degenerative dementia plus stroke," says Barba. Also in the August issue of...Omega-3 fatty acids may prevent heart disease by improving arterial elasticity
... play in improving systolic and pulse pressure and vascular resistance, effects that may reduce the risk of IHD and adverse cardiac events. The research focused on the effects of two forms of omega-3 fatty acid--eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--on systemic arterial compliance, a mea...Aspirin's target, the COX-2 enzyme, linked to cancer of the uterus
...increase production of COX-2. One molecule, called vascular endothelial growth factor, is involved in promoting the growth of blood vessels that feed the growing pathological tissue. The other molecule, interleukin-1beta, is a small molecule associated with the immune system, which deploys cells to sites wher...Heart experts call for urgent action to implement new findings on cholesterol-lowering treatment
...r medical records and identify those patients with vascular disease or diabetes who we now know would benefit ...0mg beta-carotene daily) in people at high risk of vascular disease. Those results are also published today in the Lancet. Although this supplement did increas...Cholesterol-lowering drugs should revolutionise treatment of heart attack and stroke
...0mg beta-carotene daily) in people at high risk of vascular disease. Vitamin supplementation did not produce a...d-lowering therapies to prevent the risk of future vascular events by about a quarter each, in high-risk patients. The benefits of each intervention appear to b...Common diabetes drug causes arteries to spasm, endangering heart
...votal role in the regulation of blood pressure and vascular tone," said McNally. "The absence of the smooth muscle potassium channels promotes episodes of vascular spasm. Since the sulfonyureas work the same way, effectively closing these channels, we believe tha...Bleach-producing enzyme found to modulate blood vessel dilation during inflammation
...opment of drugs to treat a variety of inflammatory vascular diseases. The bleach-producing enzyme, known as my...utrophils are also known to contribute to impaired vascular function during acute inflammatory responses, we reasoned that myeloperoxidase may be a central play...