A marker for new blood vessel formation in tumors
... (PET) scanning to measure the amount of new blood vessel growth in some tumors. New blood vessel growth - angiogenesis - is important for the growth of tumors; several drugs target angiogenesis spe...Researchers search for first sign of congestive heart failure
...y naturally responds to stress by increasing blood vessel constriction and fluid volume inside vessels. The kidneys help with volume by retaining sodium. Natriuresis is the body's way of eliminating sodium so pressures can return to pre-stress levels. Dr. Harshfield's studies have shown certain populations,...Mayo Clinic discovers 'new pathway' against pancreatic cancer
...d in cancer cell survival, proliferation and blood vessel formation (angiogenesis). NF Kappa B is hyperactive in many human cancers including pancreatic. The Mayo Clinic study shows that in pancreatic cancer, the activity of NF Kappa B is regulated by GSK-3 Beta. Researchers determined this by showing tha...Drug that hinders blood vessel growth under study in ovarian cancer
...ytokines (growth factors) that stimulate growth of vessel buds around it in a process called angiogenesis. This particular medication targets receptors on new budding blood vessels in an attempt to down-regulate them and prevent growth. If that process is shut down, the tumor should not grow or spread." ...Laughter helps blood vessels function better
...n a movie that produced mental stress, their blood vessel lining developed a potentially unhealthy response ... The endothelium has a powerful effect on blood vessel tone and regulates blood flow, adjusts coagulation and blood thickening, and secretes chemicals and ...Study says rare allergic reactions to drug-eluting stents may raise risk for heart attack
... and there was a trend toward the need for target vessel revascularization (TVR). Most significantly, the 180 day myocardial infarction (MI) rate was statistically higher in the hypersensitivity group (7.9% vs. 1.1%)," says Dr. Alameddine. The Emory researchers postulate that a hypersensitivity reaction ...Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
...cases of aneurysm -- a dangerous thinning of blood vessel walls in the brain -- fall into the "sporadic" category. While development of sporadic brain aneurysm is relatively common (as autopsies have shown) many people have them and have no symptoms or warning signs that they could be at risk of catastrophi...Meditation may reduce heart disease risk
...g the meditators an increased ability of the blood vessel lining, called the endothelium, to relax. "Dysfun...d essentially no difference in the ability of that vessel to relax after stress in either group at four months. But by eight months, EDAD or endothelial-depen...'Artery clearing' system does not provide benefit for patients undergoing PCI
... severely diseased portions of the infarct-related vessel or its side branches. Vessel occlusion or aspiration of embolizing material may not have been complete; also, the protection device is not able to impede the release of soluble mediators." "The difficulty in finding convincing explanations for the la...Computer model being developed at Stanford may help surgeons better predict patient outcomes
...er versions of his simulation, which assumed rigid vessel walls for simplicity. "The physics of blood flow is so complicated that it is impossible to guess what will happen during a surgery," Taylor said. Medical professionals now have access to powerful tools for acquiring and visualizing data, Taylor note...Changing chemistry helps explain estrogen threat to the heart
...of Georgia researchers have found changes in blood vessel chemistry that may explain the dramatic flip-flop in estrogen's function that occurs in older women, taking it from a dilator of vessels to a potentially dangerous constrictor, says Dr. Richard White, MCG pharmacologist. Dr. White will present the fi...Clot-busting drugs may help detect potentially deadly leg clots
...ssolution because a clot large enough to occlude a vessel in the leg would minimize contact between the clot and the blood. Using pigs as their animal model, the researchers first performed d-dimer studies to get a baseline, then caused a clot in the femoral vein in the groin. An hour later, there were no s...Inflammatory cells highly promising target in NF 1
...bromatosis because they also are involved in blood vessel formation -- and tumors need blood vessels in orde...at target the mast cells' ability to promote blood vessel growth, Clapp and his colleagues hope to prevent tumors from getting larger. Eventually, with contin...AHA urges earlier diagnoses, referrals for PCI in women
...imize therapy for patients with diabetes and small vessel coronary disease -- two conditions prevalent in the female population. More refined treatment pathways and strategies for women with ST elevation myocardial infarction (severe heart attack in which an artery is completely blocked) where death rates ...COX-2 inhibitor increases the risk of heart attack in elderly adults with no history of heart attack
...crease the chance of a blockage forming in a blood vessel of the heart," explains Lvesque. "This study contributes to the growing body of evidence concerning the cardiac safety of COX-2 inhibitors."...Stem cells given in minimally invasive procedure improve heart function
...to become heart muscle cells or cells that promote vessel growth, or whether they serve as homing signals to other cells and substances that help with repair," explained Dr. Patel. The study took place at centers in South America. The research team obtained the necessary institutional and government health...More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...n patients with a variety of thromboembolic [blood vessel blocking, usually by a clot] condition. Marisa Battistella, B.Sc.Phm., Pharm.D., from University Health Network-Toronto General Hospital, Toronto, and colleagues analyzed information from multiple linked health care databases over one year from Apri...JCI table of contents, January 20 2005
... TITLE: Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. AUTHOR CONTACT:Donald M. McDonald Department of Anatomy, University of California, San Francisco, California, USA. Phone: 415-476-2118; Fax: 415-476-4845; E-mail: dmcd@itsa.uc...Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications
...intestinal ulcers, through inhibition of new blood vessel growth, it may impair healing of background ulcers. When combined with the propensity to increase bleeding, these agents may convert small, silent ulcers into large ulcers that bleed profoundly." Consequently, Dr. Cryer recommends that patients at hi...Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
...cells called macrophages that invade the hardening vessel wall. Given what they had seen with the TxA2 blocker, FitzGerald's group figured that they might need to add the TxA2 blocker to see the anti-inflammatory benefit of the COX-2 inhibitor. Adding the COX-2 inhibitor not only failed to add to the benef...