Zebrafish: Drug discovery of a different stripe holds promise in COX research
... and COX-2 were extensively expressed in the blood vessels of zebrafish, but with different patterns of distr...mans, prostaglandin products of COX-1 causes blood vessels to constrict and platelets to become sticky - the first step in a heart attack or stroke. COX-2 prod...Angiogenic therapy offers promise for reducing claudication
...FGF-2) can cause growth and proliferation of blood vessels from existing vascular structures (angiogenesis). Robert Lederman, formerly of the University of Michigan, Brian Annex from Duke University Medical Centre, USA, and colleagues investigated whether one or two doses of intra-arterial rFGF-2 improves ex...Angiogenesis reduces leg pain from clogged arteries
...es of patients with painful blockages in the blood vessels in their legs. The phase II randomized doubl...laudication -- a condition marked by clogged blood vessels in the legs -- which leads to severe and often debilitating pain during walking. This pain is simila...Insulin sensitizer has anti-inflammatory effect in diabetics
...also improved vascular reactivity - the ability of vessels to expand and contract in response to changes in blood flow -- which is crucial for maintaining healthy blood pressure and blood flow to vital organs. ...Eating high-fat meal raises blood's proinflammatory factors; vitamins E, C counter response
...sugar and fat caused a reduction in the ability of vessels to expand and contract in response to changes in blood flow, actions crucial for maintaining healthy blood pressure and blood flow to vital organs. In yet another study, eight subjects took 1,200 I.U. of vitamin E and 500 mg. of vitamin C before a g...Gout drug shows promise in treating chronic heart failure
...uch as the ankles, he says. In people with HF, the vessels fail to relax, forcing the failing heart to work e...inner lining of the arteries) that dilates healthy vessels to accommodate increased demands during exercise. In this randomized, placebo-controlled, double-b...Women with ovary disease may also have high risk for heart disease
...fatty plaque forms and builds in artery walls, the vessels lose some of their elasticity. "The implication is that a common condition thought to be primarily a gynecological problem may predispose women to heart disease," says lead author Paul Hardiman, M.D., a senior lecturer in obstetrics and gynecology at...PET/CT may identify 'vulnerable' aortic plaque
... pathological changes in the aortic wall and blood vessels that may cause severe cardiovascular events in the future, according to results of a study released at the Society of Nuclear Medicine's (SNM) 49th Annual Meeting in Los Angeles. Such scans could be useful in disease prevention and in monitoring pati...Drugs may not be best weapon against teen migraines, study finds
...re in their fingers, a process that triggers blood vessels in the head to relax, lessening headache pain. "Interestingly enough, it was a lot easier for the teen-agers to do the biofeedback than for adults," Cottrell said. "Maybe it was because it uses a computer and kids thought it was cool or maybe kids ...New pathway for treating hypertension-related kidney failure studied
...trienoic acids, or EETs, that not only relax blood vessels but also reduce inflammation. Arachidonic acid is ...d flow by relaxing the smooth muscles of the blood vessels and also works as an anti-inflammatory agent. In kidney disease, EETs are broken down by an enzyme,...Adaptive optics technology provides powerful tools for eye doctors
...h individual blood cells moving through tiny blood vessels in the retina. Confocal imaging enables the instrument to focus separately on the different layers of cells within the retina, revealing nerve fibers, blood vessels, and light receptors with a clarity that is greatly enhanced by adaptive optics. "Usi...Hypertension is study focus of $10 million NIH grant to MCG
...o stress and sodium occur, how damage to the blood vessels results and how it might be prevented. One project under the NIH grant will continue Dr. Treiber's longitudinal studies of children with a family history of hypertension. But now he'll be looking at whether environmental stressors such as low socio...New cold treatment developed at the University of Virginia
...ptoms: Stuffy nose results from dilation of blood vessels in certain tissues in the nose called turbinates. When the blood vessels dilate, turbinates swell and block air passages, making breathing through the nose difficult. Certai...Drug developed at Duke appears effective in treating respiratory failure in newborns
... this potentially life-threatening disorder, blood vessels within the lungs constrict, severely limiting the amount of blood flowing through the lungs, leaving the body starved of oxygen-rich blood. "Our study showed that this new drug improved the oxygenation of seven babies with persistent pulmonary ...High-volume hospitals equal higher survival rates for bleeding strokes
...a blood vessel bursts within the weblike system of vessels and capillaries surrounding the exterior surface of the brain. SAH can cause brain damage, coma and death. Data on 12,804 patients (62 percent female, average age 52,) admitted to 390 hospital emergency departments for SAH were examined, and outcome...High cholesterol elevates women's risk of stroke death
...iated with strokes caused by clots or narrowing of vessels that carry blood to the brain. Most of the remain...ol also contributes to plaque buildup in the blood vessels leading to the brain, as well as in the vessels of the brain itself. A blockage in these vessels ca...Aspirin's target, the COX-2 enzyme, linked to cancer of the uterus
...f the malignancies and promote the growth of blood vessels that deliver nourishment to the lesions. Currently...ctor, is involved in promoting the growth of blood vessels that feed the growing pathological tissue. The other molecule, interleukin-1beta, is a small molecul...Grant of 20 million to establish the Schistosomiasis Control Initiative
... pair up and then live for many years in the blood vessels around the bladder and intestine, feeding off the ...body daily, but do so by rupturing capillary blood vessels causing heavy blood loss. Those eggs which do not escape become trapped in the liver, causing a blo...Genetic variant reduces immune response, yet protects against atherosclerosis
...ls, airway epithelial cells and cells lining blood vessels -- are crucial to immune responses to bacteria. Th...The diminished levels of inflammation within blood vessels and the enhanced risk of severe bacterial infections found in the patients with the TLR4 polymorphis......vessels. Nitric oxide regulates the tone of blood vessels by causing them to relax, or dilate, to increase b...ed vasodilators that elicit this response in blood vessels can prevent HAPE as well as treat it. "This is the first report of a positive genetic association of...