Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
...ng along signals. For example, a cancer-causing agent or a hormone may find its way from the bloodstream...e culprit. But to cause cancer, an enzyme or other agent is expected to be active all the time, like a light with no off switch. MEK, however, is never activ...Benefits of trastuzumab are lasting, reducing both HER2 + breast cancer deaths and recurrence
...herapy, she says. Targeted therapy uses a specific agent directed against a particular change in a cancer cell. Researchers also found that the highest risk of relapse occurs within the first two years, and that recurrences continue to occur with longer follow-up. Breast cancer is also more likely to re...Vorinostat shows anti-cancer activity in recurrent gliomas
...inostat is the first FDA approved oral anti-cancer agent that inhibits an enzyme, histone deacetylase, that is closely associated with DNA in cells. By inhibiting the deacetylation of histones -- proteins that help organize the structure of DNA -- vorinostat alters the expression of several important genes...Phase II study shows combination improves survival of metastatic melanoma patients
CHICAGO -- Two chemotherapy drugs combined with an agent that prevents the growth of blood vessels signific...combination of chemotherapy with an antiangiogenic agent may be a valid treatment strategy for these patients. But the only way to know this for certain is a...VEGF Trap shows activity in patients with advanced ovarian cancer
...EGF Trap is administered intravenously as a single agent in one of two dose levels. It works by blocking the development of new blood vessels to the tumor (angiogenesis) which stops tumor growth and the spread of cancer to other parts of the body (metastasis). It can also result in tumor shrinkage. VEGF Tr...Shark cartilage shows no benefit as a therapeutic agent for lung cancer
...r Neovastat, has shown no benefit as a therapeutic agent when combined with chemotherapy and radiation for ...strate that AE-941 is not an effective therapeutic agent for lung cancer," says Lu. "So, too, these findings have to cast major skepticism on shark cartilage...Targeted, oral agent Enzastaurin shows favorable results
...r evaluation of en-zastaurin in NSCLC, as a single agent or in combination, is warranted, said chief investigator for the study, Gerold Bepler, M.D., Ph.D., chief of thoracic oncology at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. Additional data presented at ASCO this yea...Adding medication improves recovery for elderly with depression, says Pitt School of Medicine study
...ne or lithium. Researchers selected the additional agent that each participant received based on individual medical status and history. Thirty-six participants either declined new medicine or did not receive augmentation because of accompanying medical conditions. Half of the patients who did not respond......entists were surprised to find so quickly that one agent showed promise: NDGA, a compound derived from creo... This is the first time to my knowledge when an agent has been shown to extend median life span in three laboratories, says Miller, professor of pathology...Better insight into brain anatomical structures
...adolinium complexes currently used as MRI contrast agent cannot reveal anatomic structures. As reported in ...l University have now developed a new MRI contrast agent using manganese oxide nanoparticles that produces images of the anatomic structures of mouse brain w...Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
...this type of therapy is delivering the therapeutic agent into the body and then to the tumor in a safe and effective manner. By using targeted nanoparticles, researchers have demonstrated that systemically delivered siRNA can slow the growth of tumors in mice without eliciting the toxicities often associat...Cow protein aids in treatment of gastrointestinal disorder
...clinicians are realizing that use of an additional agent may be necessary for therapy....Dealing deadly cancers a knockout punch
...iding significantly stronger responses than either agent alone. In addition, other studies completed in...ced enhanced tumor regression compared with either agent alone, and without additional toxicity. Oncolytics has permission from the U.K. regulatory authoriti...Effectiveness of first renin inhibitor drug for treating hypertension is limited
...iren was not more effective as an antihypertensive agent than CEIs, ARBs or diuretics and it has a limited antihypertensive dose response curve. Although aliskiren lowered blood pressure to a greater extent when combined with a CEI or an ARB or a diuretic, blood pressure control was achieved by less than 5...Agent protects cells from lethal effects of radiation even if given after exposure
...edicine in St. Louis report they have developed an agent that protects cells from the lethal effects of rad...it is given before or after exposure. Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are mo...Less sun better than using sunscreen
...cation and the specific absorption spectrum of the agent used. "Application of organic sunscreens should be done 15-30 minutes before going out into the sun. Waterproof or water-resistant sunscreens should be used to diminish the need for reapplication after swimming followed by towelling, friction with...Assessment model based on medical history gauges lung cancer risk
...ers. In contrast, hay fever worked as a protective agent against lung cancer in both groups. The study is not without limitations. One major drawback is that the model focuses only on Caucasians, due to the fact that there were not enough minority patients in the cohort to build and validate the model. "...Malaria-infected mice cured by 1 dose of new drug
...ns Hopkins trioxanes mimic artemisinin, the active agent in a Chinese herbal drug used to treat malaria and other fevers for thousands of years. Artemisinin comes from the Artemisia annua plant, an herb also known by a variety of names including sweet wormwood. The oxygen-oxygen unit in the peroxides cau......tors could combine to make Y. Pestis an attractive agent for bioterrorism its wide distribution, simple culture techniques, the high mortality rate of the associated pulmonary disease, availability of expert advice from former weapons scientists, or perhaps only the knowledge that many countries have inve...Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
...Scientific Session assessed whether adding a novel agent with antioxidant and anti-inflammatory properties to optimal medical therapy would reduce coronary events and death among patients with heart disease. ACC.07 is the premier cardiovascular medical meeting, bringing together more than 30,000 cardiologi...