Tag: "jci" at medical news

JCI Table of Contents, April 3, 2006

EDITOR'S PICK... ... ...... Weekend athletes who overexert themselves running or playing basketball may one day reap the benefits of research that shows adult stem cells can make new tendon tissue. Researchers Dan Gazit and colleagues at Hadassah Medical Center in Israel engineered mouse mesenchymal stem cells (MSCs), which reside in the bone marrow and fat tissue, to express a protein called Sm...

JCI table of contents -- May 17, 2007

... ... ... In normal prostate epithelium, cells coexist in many stages of development/...

JCI table of contents: May 10, 2007

... ... Patients with the syndrome leukocyte adhesion deficiency (LAD) III suffer from recurrent infections and an increased tendency to bleed. The exact defect responsible for this disease remains unclear. In a study appearing online on May 10 in advance of publication in the June print issue of the Journal of Clinical Investigation, Denisa Wagner and colleagues from Harvard Medical School sh...

JCI table of contents: May 1, 2007

... ... The drug metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes and results in an array of therapeutic benefits. Although it has been used for over 30 years, only recently have studies begun to reveal the molecular events responsible for its therapeutic effects. Notably, these studies have shown that metformin acts by phosphorylating the enzyme AMPK, t...

JCI table of contents: August 10, 2006

... ... Neurofibromatosis type I is a common genetic disorder in which tumors grow along certain types of nerves and can also affect other tissues such as bone, heart, and skin. The condition is caused by a mutation in the gene coding for Neurofibromin (NF1), a GTPase-activating protein (GAP) that triggers the abnormal activation of the protein Ras, and clinical trials are currently underway u...

JCI table of contents: July 3, 2006

EDITOR'S PICK...... ...... Three years ago, 39-year-old Terry Wallis who had persisted in a minimally conscious state (MCS) for 19 years after a traumatic brain injury resulting from a motor-vehicle accident, recovered basic motor function and the power of speech. Using state-of-the-art structural and functional neuroimaging techniques, Henning Voss and colleagues from Cornell University have no...

JCI table of contents, June 8, 2006

EDITOR'S PICK...... HtrA1 protein contributes to the development of resistance to chemotherapy in ovarian and gastric cancers... ...... While many cancer patients initially have a favorable response to chemotherapy for the treatment of solid tumors, resistance to treatment often develops. Resistance can be caused by many factors, including metabolism of the drug, a decrease in drug accumulation...

JCI table of contents, May 11, 2006

EDITOR'S PICK...... ...... Long-term therapy with some antiepileptic drugs and antibiotics can cause osteomalacia, a condition marked by softening of the bones that is usually the result of vitamin D and calcium deficiency. However, the molecular mechanism of drug-induced osteomalacia remains unclear. In a study appearing online on May 11 in advance of print publication in the June issue of the...

JCI table of contents: May 4, 2006

EDITOR'S PICK...... ...... In allergic diseases such as asthma, hay fever, and rhinitis an allergen stimulates the release of antibodies that attach themselves to mast cells causing these cells to release histamine, which can cause symptoms like itching of the nose, skin and eyes, sneezing, and wheezing. The characteristic "Th2 immune response" observed in allergy sufferers is an acquired immune...

JCI table of contents: May 1, 2006

EDITOR'S PICK... ...The odd couple: unlikely receptor pair key to failed asthma treatments ... ...During an asthma attack, a group of drugs known as beta2 agonists can activate the beta2-adrenergic receptor (beta2AR) present on airway smooth muscle cells, causing the airways to relax and the attack to subside. These receptors often exist in identical pairs called homodimers. More recently it has...

JCI table of contents, April 20, 2006

EDITOR'S PICK...... ...... Researchers have now carefully crafted a combination therapy that reverses recent-onset type 1 diabetes in 2 animal models of disease. By combining an oral with an intranasal therapy for type 1 diabetes that have individually shown beneficial, but limited, effects in previous studies, Matthias von Herrath and colleagues at the La Jolla Institute for Allergy and Immunolo...

JCI table of contents, April 6, 2006

EDITOR'S PICK...... ...... Huntington disease (HD) is a degenerative brain disease in which brain cells called neurons die as a result of aggregations of the polyQ-huntingtin protein. Symptoms include involuntary movements, personality changes, and dementia, and unfortunately, there is no effective treatment to delay or prevent HD. In a study appearing April 6 in advance of print publication in...

JCI table of contents, January 26, 2006

...... ... Cataracts are a leading cause of blindness worldwide. Using a rat model of cataract formation, Masayuki Mori and researchers at Shinshu University Graduate School of Medicine in Japan have now found a link between cataracts and cholesterol. The study, appearing online on January 26 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation repo...

JCI table of contents: January 19, 2006

...... Vitamin D signals to prevent bone loss during osteoporosis... ... The risk of bone fracture resulting from falls increases as we age due to bone loss and osteoporosis. Physicians have routinely prescribed vitamin D and vitamin Drelated drugs to retard bone loss, but until now, little was known about the specific targets of vitamin D in bone. In a study appearing online on January 19 in ad...

JCI table of contents: December 8, 2005

... ... ... ...Current hypotheses suggest that it is the accumulation over time of amyloid beta peptide 142 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease. The reduction of amyloid levels is therefore a major therapeutic objective. Todd Golde and colleagues from the Mayo Clinic Jacksonville report evidence to suggest that prevention of amyl...

JCI table of contents: December 1, 2005

...Battle of the bulge: Why losing weight is easier than keeping it off for good ...... You've successfully dropped those extra pounds only to discover that they creep back on again. Columbia University researchers may have now worked out why. In a study appearing in the December 1 issue of the Journal of Clinical Investigation, Michael Rosenbaum and colleagues from Columbia University College o...
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