St. Jude, El Salvador create research ethics committee
... The new programs not only ensure rigorous ethical oversight of research involving human participants, but also serve as a model for other institutions in high-income countries to create or strengthen existing RECs in low-income countries, the investigators said. A repor...St. Jude finds clues to hearing loss from chemotherapy
MEMPHIS, Tenn. Sept. 26, 2006 -- Children with cancer who suffer hearing loss due to the toxic effects of chemotherapy might one day be able to get their hearing back through pharmacological and gene therapy, thanks to work done with mouse models at St. Jude Children's Research Hospital. Mice with a variety of genetic mutations that disrupt different parts of the ear will also help scientists u...St. Jude first to describe new statistical method
... ... The St. Jude report is the first to describe...St. Jude helps Brazil improve outcomes of children with leukemia
St. Jude Children's Research Hospital has significantly reduced the rate at which families in Recife, Brazil abandon treatment for their children who have acute lymphoblastic leukemia (ALL), and has significantly increased the rate of event-free survival during a single decade. Event-free survival is the length of time after treatment that a person is free of treatment side effects, cancer recurr...St. Jude test of bird flu vaccine proves successful
A commercially developed vaccine has successfully protected mice and ferrets against a highly lethal avian influenza virus, according to the investigator who led the study at St. Jude Children's Research Hospital. The vaccine was developed by Vical Incorporated in San Diego, California. ...This finding, coupled with results of previous studies that showed protection against multiple human influen...St. Jude unlocks mystery of very aggressive leukemia
Investigators at St. Jude Children's Research Hospital have used mouse models to determine why some forms of acute lymphoblastic leukemia (ALL) are extremely aggressive and resist a drug that is effective in treating a different type of leukemia. ... The investigators found that the combination of a mutation called Bcr-Abl and the loss of both copies of the tumor suppressor gene Arf in bone marro...St. Jude develops more affordable ALL follow-up test
Investigators at St. Jude Children's Research Hospital have developed a relatively simple and inexpensive test that identifies children with acute lymphoblastic leukemia (ALL) who have responded well enough to their first round of chemotherapy that they might be successfully treated with a much less aggressive follow-up treatment. ...... The new test could give hospitals with limited resources a...St. Jude conducts first large-scale bird flu genome study
Unique resources at St. Jude Children's Research Hospital let researchers generate a "gold mine" of data to track evolution of bird flu virus genes and understand how they cooperate to cause disease... ...Investigators at St. Jude Children's Research Hospital have completed the first large-scale study of bird flu virus genomes, thereby doubling the amount of genetic information available on the g...St. Jude projects 90 percent cure rate for ALL
The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia (ALL) could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to investigators at St. Jude Children's Research Hospital. Almost 4,000 cases of ALL are diagnosed in the United States each year, about two-thirds of which are in...Collapse of p53 into clumps might be linked to cancer, according to St. Jude
...(MEMPHIS, TENN.--Dec. 1, 2005) The disruption of a molecular bridge that holds together the molecule p53 tends to destabilize this protein, allowing it to form potentially disease-causing aggregates, or "clumps," according to a study by investigators at St. Jude Children's Research Hospital. ... The mutation that causes clumps to form is associated only with the pediatric cancer adrenocort...Genetically modified cells migrate to brain and treat neurodegeneration in St. Jude model
Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses). This discovery occurred based on results of a laboratory study of the technique published by investigators at St. Jude Children's Research Hospital. A report on this work appears in th...Fine tuning drug levels in neuroblastoma patients is effective, St. Jude researchers show
Monitoring and fine tuning the levels of the cancer drug topotecan in children with neuroblastoma holds promise for maximizing the drug's effectiveness while reducing its toxicity, according to investigators at St. Jude Children's Research Hospital. ... ...Neuroblastoma is a tumor of nerve tissues in the neck, chest, abdomen and pelvis. This cancer usually arises in the tissues of the adrenal gla...