MRI study shows hormone leptin alters brains, may ease cravings of people with obesity gene
...imaging (MRI) study finds that the protein hormone leptin promotes development of gray matter in the part of...lity to monitor personal behavior. After receiving leptin replacement therapy, research subjects with a recessive mutation in the obesity (ob) gene a populat...Researchers consider possible mechanistic links between obesity and asthma
...pro-inflammatory and obese individuals have higher leptin levels than lean individuals. Leptin is found at higher levels among asthmatics regardless of the extent of obesity. In contrast, blood levels of another hormone, adiponectin, which has anti-inflammatory properties, are actually lower among obese i...Smoking and obesity accelerate human ageing
... the concentrations of a body fat regulator called leptin and telomere length in blood samples from the women. They found that telomere length decreased steadily with age and the telomeres of obese women and smokers were much shorter that those of lean women and never-smokers. Lean individuals had significa...BIDMC investigator receives Novartis Award in Diabetes
...ical School, Mantzoros is a leader in the field of leptin research whose work has advanced the understanding of leptin as a hormonal mediator of the adaptation to starvation. In clinical studies published in 2003, Man...High fat diet alters hepatic immune system in mice
... cells. However, since obese humans have increased leptin levels, the researchers were not sure if their findings in mice were relevant to human fatty liver disease. To address this question, they studied a new diet-induced model of non-alcoholic fatty liver disease. The researchers, led by Zhiping Li of J...New findings help explain how brain pathways control body weight
...e than a decade ago with the identification of the leptin hormone and which has been growing steadily ever s...formation provided by circulating hormones such as leptin and ghrelin and from fuels such as glucose and fatty acids). It then integrates this sensory informa...Battle of the bulge: Why losing weight is easier than keeping it off for good
...s, the authors administered "replacement" doses of leptin to lean individuals that had recently lost weight ... were actually reversed once circulating levels of leptin were restored to levels that were present prior to weight loss. These mechanisms lie at the center o...JCI table of contents: December 1, 2005
...s, the authors administered "replacement" doses of leptin to lean individuals that had recently lost weight ... were actually reversed once circulating levels of leptin were restored to levels that were present prior to weight loss. These mechanisms lie at the center o...Statement on NIH research on obesity and type 2 diabetes
... The discovery of the appetite-controlling hormone leptin in 1994 led to an explosion of research discoveries elucidating the metabolic and neurobiological mechanisms that regulate appetite, energy expenditure, and energy storage. Today, the NIH continues to support an expansive basic research portfolio on ...Blockade of fat hormone helps halt and heal multiple sclerosis
...rom Universit di Napoli "Federico II" suggest that leptin neutralization may be a potential way to both prev... response. Since it had been previously shown that leptin is expressed in active inflammatory lesions of the central nervous system during EAE and MS, Matares...New key brain target of fat hormone
...area of the brain that responds to the fat hormone leptin in regulating body weight and energy expenditure. ...t diet. Their discovery, they said, indicates that leptin acts on more brain areas than previously believed, to regulate body weight. Leptin is secreted by fa...High risk of breast cancer associated with genetic variation in leptin and its receptor
...ons that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others. A study published today i...Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
... Alterations in the leptin-making gene may create leptin deficiency linked to obesity and other defects in ...y in people is associated with an inability to use leptin made naturally in the body, says Hare, who also is director of the cardiovascular section of Hopkins...Asthma risk increased in women with high levels of fat tissue inflammatory protein
...to influence the findings, the association between leptin and asthma appeared to be stronger in women than i...sk of asthma, this was not explained by their high leptin levels. This suggests that the protein may not be responsible for the link between overweight and a...Too much or too little sleep increases diabetes risk
...nsulin resistance, and lower levels of the hormone leptin leading to obesity. The mechanisms by which long sleep duration increase diabetes risk requires further investigation. "There is a lot of interest in determining whether sleep disturbances such as a reduced amount of sleep or disorders like sleep ap...New research links metabolism and appetite suppression, opening door to obesity treatments
...e stimulated by exercise. "While hormones such as leptin were initially thought to be the cure-all for weig...ignificant because this new pathway that overcomes leptin resistance opens the door to a more promising avenue for the development of a therapeutic anti-obesi...American Academy of Neurology 58th Annual Meeting scientific highlights
...ly followed over five years, those with the lowest leptin levels had a greater decline in their cognitive ability than those with the highest levels. Sex hormones may also play a role in the risk for cognitive decline. In a study of almost 800 men and women, those women with the lowest levels of estradiol ...Behavioural therapy can restore ovulation in infertile women
... of major metabolic changes such as an increase in leptin or thyroxine (a hormone that affects how cells use energetic compounds). Since CBT caused a drop in cortisol and a rise in TSH, it may be that the hypothalamic-pituitary-thyroid axis, involved in the regulation of metabolism, recovers, but only late...Hormones could be prescription for living longer
...f adiponectin as well as much lower levels of both leptin and insulin. Moreover, the oldest-old women scored better with respect to insulin resistance and total cholesterol. Compared to the obese women, who, as expected, had more evidence of metabolic disturbances, the centenarians had significantly fewer s...Childhood obesity caused by 'toxic environment' of Western diets, study says
...ormally are regulated by leptin, Lustig says. When leptin is functioning properly it "increases physical act...ncreases feelings of well-being." Conversely, when leptin is suppressed, feelings of well-being and activity decrease and appetite increases a state called "...