Regulator of lipid metabolism ensures high quality breast milk
... quite surprised by the unexpected quality control mechanism that ensures the quality of breast milk, says Ronald M. Evans, Ph.D., professor in the Salk Institutes Gene Expression Laboratory and a Howard Hughes Medical Investigator. Our finding explains why breast milk is always clean and healthful, even when ...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...ncer Center announced today the discovery of a new mechanism of resistance to endocrine or anti-hormonal therapies, such as Tamoxifen and Faslodex. This research may allow oncologists to screen women for responsiveness to these treatments, and provides a much-needed clue to reversing resistance. The research, ...Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
...t vascular complications; and investigation of the mechanism of increased removal of thiamine from the blood into the urine in diabetes. ...Maternal obesity prior to pregnancy associated with birth defects
...abetes prior to becoming pregnant. Thus, a similar mechanism to that occurring in women with diabetes may be responsible for the associations observed between maternal obesity and specific categories of birth defects. Women with type 2 diabetes were excluded from the study, and when the analysis was performed ...Why women get more migraines than men
...graines. If the theory is correct, this triggering mechanism may be a new target for migraine treatment. Reporting in the Annals of Neurology, currently online, Dr. Andrew Charles, director of the Headache Research and Treatment Program in the UCLA Department of Neurology; Dr. Kevin C. Brennan, a clinical an...The Eli and Edythe Broad Foundation invests in gastroenterology's future
...FT and/or ETBF for activating Stat3 as a potential mechanism of oncogenesis of colon cancer associated with ETBF Colleen Middleton St. Ignatius College Prepatory, Chicago, Illinois Research location: University of Illinois at Chicago Relationship between EPEC-induced barrier function disruption and h...Chemical in brain acts like a fuel gauge
...tical to understanding the overall glucose sensing mechanism in the brain, added corresponding author Arshad Khan, a research assistant professor at USC. Thats why Im interested in this system, because its very poorly understood, Khan said. If we dont know how an automobiles fuel system works to begin with...Hormone therapy offers new hope for ovarian cancer patients
...h are highly sensitive to oestrogen, this blocking mechanism could slow the growth and spread of disease. The study was funded by Cancer Research UK and involved 44 women with high oestrogen receptor (ER) levels, whose cancer had relapsed after surgery and chemotherapy. Scientists used a blood-borne tumou...Study outlines how stroke, head injury can increase risk of Alzheimer's disease
...n increase the risk of Alzheimers disease, but the mechanism underlying that increased risk has not been understood. Alzheimer's disease is characterized by plaques within the brain of amyloid-beta protein, which is toxic to brain cells. Amyloid-beta is formed when the larger amyloid precursor protein (APP) i...Low-carb diets' effects linked to rise in newly identified 'starvation hormone'
...ss, according to Maratos-Flier. Yet the underlying mechanism responsible for the profound physiological changes that the diets induced wasnt fully understood. In the new study, Maratos-Fliers team examined changes in gene activity occurring in mice fed a high-fat, low-carb diet for 30 days. Their comprehensi...Study identifies new regulator of fat metabolism
...oness Medical Center (BIDMC) have identified a key mechanism behind this turn of events. Their findings, which ... that increased levels of FGF21 may be a potential mechanism behind low-carbohydrate diets beneficial properties when it comes to lipid metabolism, says Maratos-...Tony Hunter receives Robert. J. and Claire Pasarow Award for Cancer Research
...triggered by external stimuli, acts as a signaling mechanism for cells to respond to their environment, and in particular to respond to factors that promote cell proliferation. Dr. Hunter discovered that phosphorylation of tyrosine, one of the 20 amino acids found in proteins, governed how cells multiply. The ...Targeted, oral agent Enzastaurin shows favorable results
...le for the study was based on en-zastaurins unique mechanism of action as a serine/threonine kinase inhibitor, which is believed to suppress signaling through the PKC- and PI3K/AKT pathways. Historically, over-expression and ac-tivity of PKC- and PI3K/AKT have been associated with poor prognosis and treatment ...FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
... President and CEO of DEY. ZYFLO CR has a unique mechanism of action that, combined with its twice-daily dosing regimen, could fundamentally expand and improve the treatment options available to asthma patients. We are delighted to participate in commercializing Critical Therapeutics ZYFLO CR, which will co...Detecting cold, feeling pain: Study reveals why menthol feels fresh
...e sensation. But in so doing it also illuminates a mechanism that mediates how the body experiences intense sti...D, also of UCSF, is a pioneer of research into the mechanism of chronic pain within the central nervous system. The Julius team's complementary work is focuse...Innovative device to treat brain cancer shows promise in early studies
...15.3%, and 29.3 weeks, respectively. "The novel mechanism of action of the Novo-TTF relies on the physical properties of the cancer cells, their shape and size, rather than the chemical make-up. We believe that this distinction enables the device to stop local proliferation and metastasis of cancer, which w...'Smart' mice teach scientists about learning process, brain disorders
...of the journal Nature Neuroscience , reveal a new mechanism of learning in the brain, which might serve in humans as a target for treating disorders such as post-traumatic stress disorder, Alzheimers disease or drug addiction, the researchers said. "Its pretty rare that you make mice smarter, so there are a...Drinking 4 or more cups of coffee a day may help prevent gout
... the incidence of gout among the subjects. On the mechanism of these findings, Dr. Choi speculates that components of coffee other than caffeine may be responsible for the beverages gout-prevention benefits. Among the possibilities, coffee contains the phenol chlorogenic acid, a strong antioxidant. While n...New insights into chronic inflammation and atherosclerosis
...o inflammation in healthy individuals as well, the mechanism of inflammation and the reason for accelerated atherosclerosis in patients with inflammatory rheumatic disease remain unclear. Does atherosclerosis result from systemic inflammation, a hallmark of these rheumatic diseases, or from local inflammation......e made significant new insights into the molecular mechanism by which BRCA1 recognizes sites of DNA damage that breast-cancer-causing mutated forms of BRCA1 cannot recognize," says co-senior author Roger Greenberg MD, PhD, Assistant Professor of Cancer Biology at Penn. "Now we have gained a partial understandi...