New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
... XBP1 may give us a much-needed clue for better predicting response to anti-estrogen therapies like Tamoxifen, explained Clarke. The presence of the activated protein at high levels should predict estrogen independence and thus resistance to these therapies. In the future, Clarke also hopes to develop a ne...NIH scientists target future pandemic strains of H5N1 avian influenza
...ol of Medicine. Success hinges on anticipating and predicting the crucial mutations that would help the virus spread easily from person to person. Led by Gary Nabel, M.D., Ph.D., director of the NIAIDs Dale and Betty Bumpers Vaccine Research Center (VRC), the team is reporting in the August 10, 2007 issue of...Miniature implanted devices could treat epilepsy, glaucoma
...technologies being developed aim to change that by predicting the onset of seizures and immediately dispensing a chemical called a neurotransmitter directly to the area of the brain where the seizure is starting. The Purdue researchers will work with Dr. Robert Worth, a neurosurgeon at the IU School of Medici...Novel candidate biomarker for heart failure also strongly predicts risk of death
...eral complementary biomarkers will be superior for predicting risk than using just one. If we could harness the information these biomarkers yield to better adjust therapies in the same way that antibiotics are chosen based on the organism causing the infection that would be revolutionary. A condition in...New algorithm matches any tumor cells to best possible anti-cancer treatments
...ing aspect of this research is that in addition to predicting patient responses to therapy, the COXEN algorithm can be used to discover effective compounds in any form of cancer. By the nature of the algorithm, which examines both cancer cells and drug activity at the molecular level, these newly discovered dru...New heart disease risk score will help minimize health inequalities
A new score for predicting the risk of heart disease gives a more accurate measure of how many UK adults are at risk of developing the disease and which adults are most likely to benefit from treatment. The study, published on bmj.com on July 6, estimates that in the genera...Children's brain responses predict impact of sleep loss on attention
... accounted for 44 percent of the total variance in predicting NEPSY Visual Attention scores after the children's sleep was reduced for one week. "These data are interpreted to suggest that neutral based risk factors can signal the cognitive resilience of individuals in handling subsequent sleep loss," said Mi...Pancreatic surgery riskier for obese patients
...MI has been demonstrated to be an important factor predicting perioperative morbidity and mortality in patients undergoing numerous operations, Dr. Berger added. At the time of surgeries, 85 (46 percent) patients were normal weight, 54 (29 percent) were overweight and 45 (25 percent) were obese, the study ind...Gender impacts colorectal cancer progression
...esearchers were able to identify molecular markers predicting response time to tumor progression and overall survival. When we stratified for men and women, different genes appear to be predictive for outcome, says Lenz. This is the very first study showing that molecular markers may be sex specific. There...Exercise test may help predict mortality risk in heart failure patients
...sk of death," said Kitzman. Previous studies on predicting mortality have focused on systolic heart failure patients. The current study was the first to compare the pulmonary test in three groups: older adults with diastolic heart failure, older adults with systolic heart failure and healthy volunteers of th...Study finds 'wake up and breathe' strategy allows patients to come off ventilator sooner
...mbers on the monitor in the ICU arent very good at predicting if a patient is ready to come off a ventilator, Dr. Girard says. In the past, the process of turning sedation drugs off has been done separately from turning off the ventilator. Our study proved our hypothesis that if we connect these two processes, ...Lowering body temperature could aid standard stroke treatment
...ots and plasma, the findings could prove useful in predicting the efficacy of tPA over a wide range of temperatures, the UC researchers say. The work is reported in the May 2007 issue of Physics in Medicine and Biology. It is already known that lowering a patient's temperature reduces the metabolic activity...A self-fulfilling prophecy in bleeding stroke?
...turer at the U-M Medical School. "The challenge is predicting who is whom." "Our goal should be to develop therapies that will lead to survival with good outcome rather than survival with severe disability," says senior author Lewis Morgenstern, M.D., director of the U-M Stroke Program and of the Texas stroke...Why predicting the next influenza pandemic is difficult and how scientists can best prepare
...s at the National Institutes of Health discuss why predicting the next pandemic is so difficult and outline steps that can be taken to better understand the behavior of the virus. Drawing upon the lessons of past pandemics, the authors analyze the significance of the highly pathogenic avian influenza strain H5N...Liver stiffness indicates portal hypertension
...ion. To date HVPG still is the gold standard.. for predicting clinical decompensation and the response of portal pressure to pharmacological therapy....Johns Hopkins develops pancreas cancer risk model
...emely low. To test the models effectiveness for predicting cancer, Klein and her colleagues fed the software family history information given by more than 6,000 individuals in 961 families when they initially joined the Hopkins pancreas cancer registry several years ago. Kleins team divided registrants into...Low education predicts lower quality of life for prostate cancer patients
... care. Since health care access is a key factor in predicting health outcomes, its significant that we were able to control for this variable, she says. The good news, she says, is that clinicians across the country can immediately begin to identify and help prostate cancer patients who are at greater risk fo...Carnegie Mellon researcher wins prestigious career award for NSF
...eriments and computational models are effective at predicting these tribological phenomena. The study of friction, lubrication and wear is called tribology. "With the growth in computational power, we believe these types of tribology problems can be predicted and we can ultimately understan...CryoSat-2 on the road to recovery
... plays such an important role in the Earth system, predicting future climate and sea level depends on the data that CryoSat-2 will realise. In the year since the go-ahead to build CryoSat-2, much has been achieved and the project has just passed an important milestone, that being the Critical Design Review du...Obesity and environmental chemicals -- New research probes potential link
...g underway, the scientists are duly cautious about predicting outcomes. If findings implicate PBDEs in obesity, Carey notes, the news would be good and bad. "From a scientific standpoint, it would be very interesting if these animals began to put on weight," she says. "But part of me hopes they dont, because ...