Tag: "prion" at medical news
Scientists develop method to remove prion infectivity from scrapie-infected blood
...nt on to develop the disease. Selectively removing prion
infectivity from donated blood might be one of the...to find one, called L13 that selectively binds the prion
protein (PrP). To test its binding ability, the investigators first passed 500 mL of scrapie-infecte...
The UK's third case of vCJD associated with blood transfusion
... In 2004 two transfusion-associated cases of vCJD prion
infection were reported. The patients both had a s...n. Autopsy confirmed the vCJD diagnosis and showed prion
infection. There are 24 living individuals who are known to have received a blood transfusion in ...
New technology to speed up research into Huntington's disease
...ogical dysfunction such as Alzheimer's disease or prion
disease, and particularly where motor deficits make cognitive testing difficult or impractical.Dr Morton said "we are pleased at just how effective the test was and already clinical trial companies are showing an interest in the touch screen system"....
Prion disease infectivity causes heart damage in mouse study
.... Scrapie belongs to a group of diseases called prion
diseases, also known as transmissible spongiform e...ted in the brain. In addition to scrapie in sheep, prion
diseases include Creutzfeldt-Jacob disease in humans, mad cow disease in cattle and chronic wasting ...
Incubation period for human BSE infection could exceed 50 years
...ease (vCJD), according to a study on another human prion
disease called kuru in this week's issue of The La...lleagues studied the only example of a major human prion
disease epidemic available - a disease called kuru. Kuru is caused by cannibalism and reached epidem...
Study suggests new human genotype may be prone to vCJD
...nalysed DNA from two tissue samples that harboured prion
proteins (a marker for vCJD infection) to identify...ng editorial. The study shows the existence of the prion
protein in two tissue samples, not clinical evidence of vCJD in two patients. The study also provide...
Study indicates human susceptibility for variant Creutzfeldt-Jakob disease transmission
...reds of thousands. Variations and mutations in the prion
protein (PrP) gene affect disease susceptibility, although the underlying mechanisms are unknown. Variations at a particular point on the PrP gene--codon 129--can affect the transformation of the PrP into the disease-associated form (PrPSc). A team o...
Protein sorting in pigment cells sheds light on melanoma, Alzheimer's disease
... found that the Alzheimer's precursor protein, the prion
protein (responsible for Creuztfeldt-Jakob's Disea...e treatments for diseases like Alzheimer's and the prion
diseases. "We've also shown a new way of targeting proteins to exosomes," says Marks. "If we learn ...
New test to detect rare proteins in blood
...cers (such as breast cancer), Alzheimer's disease, prion
diseases, and possibly psychiatric diseases relati...re, but medically important molecules, such as the prion
protein (for mad cow disease with Mansun Sy at Case Western University) and TNF-alpha (for autoimmun...
Journal of Alzheimer's Disease is devoted to metal ions and neurodegenerative diseases
...iseases, as well as amyotrophic lateral sclerosis, prion
diseases and others." The issue contains 11 research and review papers, a conference report from the 3rd International Conference on Metals and the Brain and the transcript of a live discussion among leading researchers in the field. With papers cove...
New method holds promise for better understanding of prion diseases
...ter of months. There are no cures or therapies for prion
diseases. The most common human prion
disease is sporadic Creutzfeld-Jacob Disease, or sCJD. Scientists still understand little about wh...
Detecting Alzheimer's in the eye, lifting fingerprints without touching the surface
...or rapidly detecting amyloidplaques resulting from prion
diseases, including mad cow, scrapie insheep, and Creutzfeldt-Jacob disease in humans. (Paper FTuBB4,Non-Invasive Optical Detection of Alzheimer's Disease -Amyloid inHuman AD and Transgenic Mouse Lenses in vivo; Tuesday, October 18,5:15 PM) This work...
Variant prion protein causes infection but no symptoms
proteins are little understood disease agents invo... research suggests that a variant form of abnormal prion
protein--one lacking an "anchor" into the cell membrane--may be unable to signal cells to start the ...
Scientists observe infectious prion proteins invade and move within brain cells
...Dr. Baron says researchers have tracked infectious prion
protein moving through other parts of animal bodie...ys, was finding a way to fluorescently tag the TSE prion
proteins without altering them--while still allowing researchers to identify the prions as they pene...
Premature use of stem cell therapy could put patients at risk
...herapy could put many patients at risk of viral or prion
diseases unless appropriate safety systems are in place, warn experts in this week's BMJ. The use of human embryonic stem cells has been hailed as the next major step in the battle against serious degenerative disorders, such as diabetes and Parkinso...
Active vaccine prevents mice from developing prion disease
...n both the United States and Europe are working on prion
vaccines. But the NYU study is important because i... percentage of animals from developing symptoms of prion
disease, explains Thomas Wisniewski, M.D., Professor of Neurology, Pathology, and Psychiatry, and th...
American Academy of Neurology sums up scientific highlights from 57th annual meeting
...ion Disease There are currently no treatments for prion
diseases, including Creutzfeldt-Jakob disease, som...in New York and Ohio showed that susceptibility to prion
infection can be reduced in mice by treatment with a monoclonal antibody to the prion. Further devel...
Study sheds light on age-related changes of prion diseases
A new study sheds light on why normal prion
proteins may experience age-related mutations in i...ne studied a previously discovered mutation in the prion
protein in members of an extended family in Indiana who inherited the prion