Scripps Research awarded $17 million for adult stem cell use to treat eye diseases
... Under the auspices of th...Synthetic production of potential pharmaceuticals dramatically simplified by Scripps research team
Chemists are currently able to synthetically produce almost any compound, but they must typically resort to expensive, complex processes that can require dozens of individual steps. Such natural product syntheses have traditionally relied on the ubiquitous use of protecting groups, which are extra compounds chemists use to shield reactive portions of a molecule during specific stages of a synthe...Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
... "While a number of new drugs that inhibit new blood vessel growth are now available in the clinics, no one so far has been cured with available anti-angiogenic agents," said Professor Martin Friedlander, a Scripps Research scientist and retina specialist at Scripps Clinic who led the study. "Our study shows that combining anti-angiogenic agents that target multiple angiogenic pathways can si...The Scripps Research Institute, McDonald's align to fight childhood obesity and type 2 diabetes
... "With obesity often comes debilitating, even fatal type 2 diabetes. These are epidemics that America...cannot ignore. The McDonald's and Scripps Research alignment represents advancement in the effort to change the landscape of these severe pediatric health issues, and to find solutions that will benefit future generations of healthy adults in America." ... "McDonald'...Scripps research team reverses Friedreich's ataxia defect in cell culture
... In the new study, the researchers tested a variety of compounds that inhibited a class of enzymes known as histone deacetylases in a cell line derived from blood cells from a Fredreich's ataxia sufferer. One of these inhibitors had the effect of reactivating the frataxin gene, which is silenced in those with the disease. The researchers then went on to improve on this molecule by synthesis...... In the new study, mature male rats immunized with specific types of the active vaccine ate normally yet gained less weight and had less body fat, indicating that the vaccine directly affects the body's metabolism and energy use. This finding may be especially important to stop what is commonly known as "yo-yo dieting," the cycle of repeated loss and regain of weight experienced by many diet...