Tag: "thymus" at medical news
Immune system lab model overcomes ethical limits on human hematopoietic stem cells studies
...em by efficiently turning HSCs into T cells in the thymus
gland was the finding of so-called "T cell recepto...l of TRECs in the blood of children means that the thymus
has converted a large number of stem cells into parent T cells--each of which targets a specific for...
Notch protein signaling directs early T-cell development
... is active in very early T-cell progenitors in the thymus
of mice. Notch contributes to the subsequent diff...nd Laboratory Medicine. "Studying events in the thymus
is important because intrathymic events may be a bottleneck in T-cell reconstitution, which is defic...
Mayo Clinic boosts immune system
... and approved drug regimen of ART to stimulate the thymus
to produce more T cells -- without provoking an "a...inic immunologist Andrew Badley, M.D. With age the thymus
(located in the upper chest) diminishes and produces fewer T cells. This leaves the elderly more vul...
High fat diet alters hepatic immune system in mice
...m/journal/hepatology . NKT cells originate in the thymus
but accumulate in the liver where they regulate the production of cytokines (cell proteins). A previous study of leptin-deficient obese mice noted depleted levels of NKT cells. However, since obese humans have increased leptin levels, the researchers...
Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body
...unction of these round blobs of cells in the human thymus
gland has now been explained. The answer, in turn,...mical signals that instruct dendritic cells in the thymus
to induce development of these regulatory T cells - the critically important immune system cells tha...
Infant transplant patients resist infections that kill adult AIDS patients
...ants underwent heart transplantation and had their thymus
removed. As a result the infants were deficient in...ansplant is carried out in very young infants, the thymus
that produces T cells is removed and a drug is given that depletes T cells," said Dr. Platt. "Yet th...
Study shows rituximab effective in treating chronic graft-versus-host disease
.... (T cells are so named because they mature in the thymus
gland, while B cells are derived from bone marrow.) This hypothesis gained traction when laboratory studies and small clinical trials showed that rituximab, which specifically targets B cells, could be effective against GVHD. The new study reinforc...
Immune system police learn early and sometimes badly
...archers followed T cells as they spent time in the thymus
then moved to the body. They found regulatory T cells learn what to protect while in the thymus
and that everything the cells learn may not be good, according to research in the August issue of Im...
New hope in cancer vaccines emerges as novel therapies are developed and tested
... says Hwu, that when sex hormones are blocked, the thymus
gland begins to produce new T cells. This is a "wonderful surprise," says Hwu, because the thymus
gland largely shuts down T cell production after puberty. "The drug will produce a working thymus, w...
Hopkins study reveals white blood cells can both hurt and help transplanted kidneys
...cells were injected into mice engineered without a thymus
gland, which produces T cells. A comparison group of genetically engineered mice got no injections. After the researchers temporarily stopped blood flow to kidneys in mice in both groups for 30 minutes, they discovered that the kidneys in the injec...
Autoimmune disease triggered if T cells miss a single protein early on
... where autoimmune disease is active, but also the thymus
-- the organ where T cells and self-proteins, or s... a severe autoimmune disease in the retina. "The thymus
is like a filter," said Mark Anderson, MD, PhD, assistant professor of medicine at the UCSF Diabetes...
Aggressive stem cells might improve transplant outcome
... stem cells or donated cellsnormally gather in the thymus
gland in the chest. There the stem cells receive t...adding both of these antibodies to pieces of human thymus
glands. The pieces of thymus
glands used in the study had been removed from children during operatio...
Thymus transplants gives hope to babies with fatal immune disease
...turn three in September, thanks in large part to a thymus
transplant she received at Duke University Medical... show that 75 percent of the babies who received a thymus
transplant were alive after one year. The recipient of the first transplant, in 1994, is alive and w...
'Nurse cells' make life and death decisions for infection-fighting cells
...gan in the upper portion of the chest. Loss of the thymus
results in severe immunodeficiency and increased s...infection. The function of T cells produced by the thymus
is to recognize harmful invaders. Once invaders have been identified, T cells then attempt to elimin...