Tag: "variant" at medical news

New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi

... Center) found that over-expression of the spliced variant of the gene in estrogen receptor-positive breast cancer cells led to reduced sensitivity to Tamoxifen and Faslodex. According to Lombardi medical oncologist Minetta Liu, MD, it is expected that all hormone receptor positive metastatic breast cance...

Genetic mutations identified for type of gastric cancer

...tributed primarily to a decrease of the intestinal variant of gastric cancer with the diffuse type remaining stable or possibly even increasing." Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the gene CDH1, and is characterized by an increased risk for diffuse gastric cancer and lobular ...

Human antibodies protect mice from avian flu

...at human mAbs may provide broad protection against variant H5N1 virusesa desirable quality in any therapeutic aimed at the constantly evolving flu virus. Taken together, the findings from this international collaboration are encouraging, says Dr. Subbarao. They show that fully human mAbs with potent H5N1 i...

Genetic marker linked to aggressive prostate cancer

...Genetics in June, 2006. Since then, the genetic variant has been widely duplicated by prestigious genetic research groups around the country. This is the first time that a genetic mutation associated with prostate cancer has been found in a large segment of the population. The initial study by deCODE gen...

Sleep deprivation can threaten competent decision-making

...oncern for negative consequences when performing a variant of the Iowa Gambling Task. While well-rested participants learn to avoid high-risk decks and to choose from the advantageous decks, sleep-deprived participants tend to continue to choose from the risky decks as the game progresses. Michael W.L. C...

UK researchers find new class of nontoxic cancer treatments

...ctly on LMP2, a component of the immune proteasome variant that has been identified abundantly expressed in certain types of tumors, including some prostate cancers. The compound, dubbed UK-101, inhibits LMP2 while not attacking normal cells, indicating that it could be an effective cancer treatment that doe...

Inflammatory system genes linked to cognitive decline after heart surgery

...r mental decline, and patients with the P-selectin variant had a 15.2 percent risk reduction. The incidence of deficit in patients with both gene variants was 17 percent compared to 43 percent in patients who had neither variant. Furthermore, patients with the two gene variants had significantly lower leve...

'Wrapping' Gleevec fights drug-resistant cancer

...e student Xi Zhang developed the wrapping Gleevec variant WBZ-7. The wrapping prototype is a kind of molecular bandage that's designed to keep water molecules from getting near the "active site" of KIT the part of the protein that imatinib targets. "Like virtually all proteins, KIT has packing defects th...

ACS News Service Weekly PressPac -- April 4, 2007

...y rats, the researchers showed that a NO-releasing variant of PAN powder, applied after balloon angioplasty, reduced formation of scar tissue in the artery. "Many applications of this chemistry in vascular surgery and other medical procedures can be envisioned," the report states. "Possible applications of t...

U of M discovers protein linked to elevated BMI in people of American Indian and Mexican ancestry

...versity of Minnesota researchers have discovered a variant of a common blood protein, apolipoprotein C1, in p...nked to lower cardiovascular disease risk. But the variant form of C1 tends to become part of low density protein complexes (LDL), which transport cholesterol ...

Scientists develop method to remove prion infectivity from scrapie-infected blood

...rapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD) in humans, are fatal neurodegenerative diseases that occur after years of incubation with no apparent symptoms. So far in the UK, three people have died from vCJD after receiving blood from donors who later went on to...

Risk of spina bifida associated with choline metabolism genes, but unrelated to choline intake

...istical power, Enaw et al.'s results show that one variant of CHKA is associated with a reduced risk of spina bifida and one variant of PCYTA1A is associated with a two-fold increased risk of spina bifida. Interestingly, these associ...

Doubts cast on organophosphate poisoning as cause of Gulf War Syndrome depression

...aken for genetic testing. Women with the genetic variant were significantly more likely to report depressio... clear organophosphates from the body, the genetic variant actually does the opposite and speeds it up, so minimising exposure. The authors point out that th...

Researchers show surprising interaction between genes, gender and hypertension

...ll anemia and Huntington's disease, where a single variant or mutation has a dramatic effect. In contrast to these single-gene-specific diseases, the UCSD researchers observed more subtle variants on six different genes, indicating that multiple genes can contribute to high blood pressure. "We discovered ...

Epidemic of multi-drug-resistant tuberculosis may be larger than previously thought

...erwise XDR-TB is bound to keep emerging as a fatal variant of TB, especially in high HIV prevalence settings. ...

The UK's third case of vCJD associated with blood transfusion

...rchers report the details of the UKs third case of variant Creutzfeldt-Jakob disease (vCJD) associated with blood transfusion in an Article in this weeks issue of The Lancet. The case highlights the risk faced by other recipients of vCJD infected blood and suggests that blood transfusion is an efficient rout...

Other highlights in the Dec. 6 JNCI

...-Induced Diarrhea Patients with a common genetic variant have an increased risk of diarrhea when treated wi...., and colleagues examined the association between variant forms of ABCG2, a protein that acts on gefitinib, and diarrhea. They found that a common variant o...

Serotonin receptor: A rheostat in brain for emotion that may be linked to depression

...nd colleagues established a brain basis for a gene variant and its relationship to behavior, finding greater amygdala reactivity in people carrying a form of a gene that leads to reduced expression of the serotonin transporter, who, because of this variation, are more vulnerable to developing depression in t...

Large collaborative effort provides first publicly available genetic data for Parkinson's research

...in PD. The authors did not find any common genetic variant that exerts a large risk for the disease. However, Singleton's team generated the first publicly available genotype data for PD that can be mined and augmented by other researchers to identify common genetic variability that results in minor and mode...

Blood transfusion-transmitted infections: A global perspective

...articularly those due to emerging agents including variant Creutzfeldt-Jakob disease (vCJD) the human counterpart to mad cow disease. With regard to the emerging pathogens, several newly-developed pathogen-reduction technologies have been shown to be effective in destroying most bacteria, viruses and para...

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(Date:4/23/2014)... term for novels and films which focus on the consequences ... how these fictions serve as a mental laboratory that allows ... imagine other living conditions. , "Global warming is much ... is also a cultural phenomenon in which meaning is being ... see. And there are so many of them now that ...
(Date:4/23/2014)... biomedical engineer at the University of Houston (UH) is ... transfusions safer. His work is supported by a $1.8 ... , Blood transfusions save millions of lives every ... Without them, for instance, routine surgeries would become life ... strong evidence that transfusions of red blood cells stored ...
(Date:4/22/2014)... to behave at the dinner tablecut up their food and ... Eating Behaviors , found that when 6-10 year old children ... such as drumsticks, whole apples, or corn on the cob ... cut. "They were twice as likely to disobey adults ... Professor and Director of the Cornell Food and Brand Lab. ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Biting vs. chewing 2
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