Genes may influence nutritional composition of breast milk
... how much of an omega-3 fat called docosahexaenoic acid (DHA) gets from a mother's diet into her breast milk. DHA, which is found mainly in cold-water fish such as tuna, salmon, and mackerel, is essential for healthy brain and eye development. DHA is now added to several brands of infant formula because ...Newly discovered 'branding' process helps immune system cells pick their fights
... example, they attach a nitrate group to the amino acid tyrosine in the peptides, changing it to nitrotyrosine. Unanue's lab then showed that these changes increased the chances that various types of T cells would react to the modified peptides shown to them by antigen-presenting cells. Unanue's group i...As morphine turns 200, drug that blocks its side effects reveals new secrets
...ium, and that I have enriched chemistry with a new acid (meconic) and with a new alkaline base (morphium), a remarkable substance." As he predicted, chemists and physicians soon grew interested in his discoveries. Serturner's crystallization of morphine was the first isolation of a natural plant alkalo...Depression common in people with chronic cough
... gastroesophageal reflux (GERD), commonly known as acid reflux. "Often the diagnosis is difficult because in many patients, cough is their only symptom." Treatments include older antihistamines combined with decongestant for cough from post-nasal drip; asthma medicines for asthmatic cough; and high doses ...Ramelteon demonstrates no abuse potential according to study results
...ational drugs work by targeting gamma-aminobutyric acid (GABA) receptors, which are located throughout the brain. In pre-clinical studies, ramelteon has shown no affinity for GABA or opiate receptors. Study Design This study was a placebo-controlled, crossover clinical study of fourteen adults with a...New technique appears to stop abnormal blood vessel growth
...ade ago, that has a tail of amino acids. The amino acid tail, a retention signal called KDEL, transforms Flt into a homing device and a death sentence for VEGF. "It's an arrest mechanism essentially," says Dr. Ambati. "It will bind and sequester. If you are VEGF and I am Flt-KDEL complex, I am going to g...Chemotherapy options improve for patients with advanced colorectal cancer
...and effective as infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) in the first-line treatme...replace the standard treatment of iv. 5-FU/folinic acid in patients with MCRC", said lead author Dr. Hendrik-Tobias Arkenau, from Clinic Bremen East in Germ...Vitamin B12 deficiency as heart risk
Robertson and colleagues state that folic acid fortification has not yet had the expected effect of reducing homocysteine levels, which are associated with carotid plaque area, a strong predictor of cardiovascular events. The authors measured levels of serum vitamin B12, homocysteine and carotid......nolic acid, oleanolic aldehyde, betulin, betulinic acid and 5-(hydroxymethyl)-2-furfural. Oleanolic acid, ... micrograms per milliliter. Betulin and betulinic acid were less effective, requiring much higher concentrations for similar antimicrobial activity. At a ...Omega-3 offers hope for new anti-breast cancer drugs
Omega-3, the fatty acid found in oily fish, could be combined with a commo...effect of two Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), combined with propofol on a breast cancer cell line in vitro...Mayo Clinic case series illuminates connection between welding, brain damage
...h ethylene diamine tetraacetic acid, a crystalline acid therapy designed to bind the acid with the excess metal in the body -- the manganese -- and neutralize the toxic effect. Dr. Josephs ...Nanoparticles carry cancer-killing drugs into tumor cells
... cells, the nanoparticle-based therapy using folic acid and methotrexate was 10 times more effective at delaying tumor growth than the drug given alone. Nanoparticle treatment also proved to be far less toxic to mice in the study than the anticancer drug alone. "In our longest trial, which lasted 99 days,...Study sheds light on why diabetes drug causes edema
... muscle, fat, kidney, and heart and controls fatty acid and lipid metabolism. In the kidney, PPAR is found in the collecting duct, a critical site for the control of fluid metabolism. To test the role of PPAR in edema, Yang created mice that specifically lacked PPAR-gamma in the collecting duct. He then ...Only transplant center that developed comprehensive protocol for liver transplants in kids with MSUD
...nto metabolic crisis and be fatal." Jakob's amino acid levels now are normal, despite a normal protein in...o set up a completely sterile room where raw amino acid powders can be prepared quickly in case there are complications from transplantation and the patient...Children's Hospital Oakland new sickle cell research
...nter at Oakland is the first to find that an amino acid deficiency in sickle cell disease is the result of...o the blood stream. Low availability of the amino acid arginine is associated with lung disease and death in adult sickle cell patients. The study, publi...UIC researchers show how cancer-preventing foods work
...oposing that the alteration of just this one amino acid in Keap1 is the critical step that spurs higher levels of the messenger Nrf2 and, consequently, increased production of the protective proteins. Keap1 is a promising new target for drugs to fight many different kinds of cancer, Mesecar said. The Ame...Lorenzo's oil shows promise in reducing risk of debilitating disease in genetic disorder
...at the striking reduction of very long chain fatty acid levels would lead to clinical benefit, none of the... the levels of the saturated very long chain fatty acid C26:0. "Patients who had a neurological abnormality had significantly higher weighted average C26:0 ...Alcohol abuse: Early diagnosis is key to treatment success
...diseases." - Obtaining high-quality ribonucleic acid (RNA) from human whole blood samples, and using it for microarray analysis, may allow for differential gene expression that can be used to identify candidate biomarkers in alcoholics. "All cells in the body respond to their surroundings," explained ...NMR method rapidly solves 8 target genomic structures
...dly to solve structures of proteins with 200 amino acid residues or more," said Szyperski, who was named one of Scientific American magazine's top 50 technology leaders in 2003. Already, Szyperski's method has been used to solve more than a dozen structures. He expects his lab at UB to solve betwe...Potential 'weak link' between virus and liver cancer discovered
... with and phosphorylates GSK-3 at a specific amino acid residue Thr 43, resulting in degradation and thus ...d a super-active mutant of the GSK-3 gene at amino acid residue Thr 43. By adding this gene into liver cancer cells, over-expression of beta catenin was dow...