Pezcoller Foundation-AACR International Award for Cancer Research
...d that the novel membrane lipid made by PI3K might act as an intracellular "messenger" by recruiting to the cell membrane the machinery (signaling proteins) needed to communicate a growth signal to the cell. Continuous activation of PI3K would allow the cell to continually grow and make copies of itself...Risk of HIV transmission highest in early stage of infection
...e rate of heterosexual HIV transmission per coital act varies over the course of HIV infection. The investigators found that the risk of transmission was highest early in infection, then dropped, then rose again late in infection. Wawer and colleagues followed a cohort of over 15,000 adults living in rur...Researcher sheds light on ghostwriting in medical journals
...ical companies hire medical education companies to act as intermediaries with researchers. She says that the current voluntary standards for declaring conflicts of interest to readers of medical journals and audiences at medical conferences are inadequate, and that a public database detailing physicians...Execution by lethal injection is not humane or painless suggests study
...killing. Those who do participate in this barbaric act are shameful examples of how a profession has allowed its values to be corrupted by state violence."...Easing the anxiety of pregnancy after miscarriage
...gnancy is not possible. Instead, it is a balancing act between trying to insure safe passage of the baby while maintaining emotional stability." A nurse specializing in the care of childbearing families, Ct-Arsenault is the first to develop a pregnancy anxiety scale that can be used to determine if a w...Drugs targeted at muscle cells
...a direct effect on the cultivated muscle cells and act independently of insulin metabolism. If we can show that the drugs are also effective on living patients, it means that they could one day be used for the treatment of patients who have developed insulin resistance."...Feeling safe and secure? CUMC scientists find it's all in the caudoputamen
...pens up hope for other types of treatment that can act on your sense of safety and security." The new safety circuit may also lead to a better understanding of addiction since the circuit operates in the same part of the brain known to be involved in addiction. "There's a feeling of invulnerability that ...New portable device developed by Georgia Tech and Emory checks for concussions on the sidelines
...ftware, a head-mounted display, earmuffs that also act as headphones and an input device (controller). The display projects the visual aspect of the test, the headphones provide the verbal instructions and the controller records the wearer's response. In addition to the advantages of its speed and portab...Discovery of a 'molecular switch' could lead to new ways of treating infection, including MRSA
...o, have identified an enzyme called IKK, which can act as a 'brake' on an immune cell pathway responsible for regulating the body's response to infection and inflammation. By inhibiting IKK activity the researchers were able to increase the body's ability to fight off infection, but at the same time als...Internet program launched to prevent blindness in diabetic patients
... diabetic retinopathy because ophthalmologists can act early. Diabetes can lead to changes in blood vessels in the retina called diabetic retinopathy. Digital photography is the key to the proposal. Trained nurses will take retinal photographs using a special digital camera, and the digital images will b...Study suggests antibiotic may limit or prevent vision problems caused by diabetes
...mage caused by microglia. Microglia are cells that act as the "cleanup crew" for the Central Nervous System (CNS). They destroy damaged cells by releasing toxins and they engulf them, much like a Pacman TM . Should they become activated and release their toxins in the retina, those toxins will kill the h...Blocking the Odc gene is effective in preventing cancers
...ng two proteins, called p27Kip1 and p21Cip1, which act as brakes on this process. In the absence of these... drug DFMO induces p27Kip1 and p21Cip1, which then act as brakes on cell division in laboratory models that normally give rise to BL. The St. Jude investig...Red delicious, Northern Spy apples have most antioxidants, chemists find
...d other cancers. Polyphenols phytochemicals that act like astringents are major sources of antioxidants in apples, but which polyphenols are most active in the fruit has perplexed scientists. Tsao and his colleagues used three different laboratory measures to evaluate polyphenol activity in apples tha...Tiny bundles seek and destroy breast cancer cells
...ure. The ceramide disrupts the mitochondria, which act as the energy producer for the cell. This causes apoptosis, or cell death. The ceramide also reduces the vascular network that feeds the tumor. In this study in mice, the ceramide bundles targeted and destroyed only breast cancer cells, sparing the s...Northwestern Memorial participates in trial to test effectiveness of drug to treat endometriosis
...hat sit on the surface of cells in the body. They act like an on-off switch for a particular activity in the cell. If the right substance comes along that fits the receptor -- like a key fitting into a lock -- the switch is turned on and a particular activity in the cell begins. "ERB-041 is a 'key...Penn study points to how COX-2 inhibitors can eventually lead to heart disease
...used by the COX-2 inhibitor. Thus, prostacylin may act to remodel blood vessels to preserve adequate blood flow. "What is really convincing here is how similarly the two models responded and how the genetics of the pharmacological approach to disrupting the effects of COX-2 had the same effect," says Rud...Dartmouth professor finds prescription drug advertising 'walks a communications tightrope'
...inguistics expert Lewis Glinert. "It's a balancing act between disclosing both the risks and the benefits of prescription medications." Glinert, Professor of Asian and Middle Eastern Languages and Literatures, studies how people use and interpret language, and two of his studies appear in the June issue...Derivatives of cannabis for anti-cancer treatment win Kaye Award for Hebrew University student
...mal studies The cannabinoid quinones were found to act through a rather unique pathway of cancer cell destruction -- by specific inhibition of topoisomerase II, an enzyme that participates in cell replication. Most of the known anti-cancer drugs are less selective, acting by numerous mechanisms. Additi...Gene linked to lower breast cancer risk
...r breast cancer risk. Cytokines are molecules that act as signals between cells. The authors were examining the cytokine IL 10, which is involved in the development of various tumors. "In breast cancer risk, IL-10 may be a two-edged sword," Dr. Langsenlehner said. "On one hand, higher IL-10 levels could...Newly published summer camp health guideline advises parents, camp directors
... and standing orders are up-to-date. They can also act as medical backups to the nurses and paramedic-trained camp health officers on site at camps -- instead of the local emergency room or urgent care center, which Walton's study found was the case 75 percent of the time. Preparing for rapid and effecti...