Tag: "amyloid" at medical news
Draining away brain's toxic protein to stop Alzheimer's
...trying a plumbers approach to rid the brain of the amyloid
buildup that plagues Alzheimers patients: Simply d...yloid-beta out of the brain and into the body. The amyloid
plaques that speckle the brains of Alzheimers patients are a hallmark of the disease, and where they...
Researchers link metal ions to neurodegenerative disease
... defined for the first time how metal ions bind to amyloid
fibrils in the brain in a way that appears toxic t...hough metal ions, most notably copper, can bind to amyloid
in several specific ways, the researchers found that only one way appears toxic. The findings wil...
Study outlines how stroke, head injury can increase risk of Alzheimer's disease
...rain cells. Amyloid-beta is formed when the larger amyloid
precursor protein (APP) is clipped by two enzymes beta-secretase, also known as BACE, and gamma-secretase which releases the amyloid-beta fragment. The usual processing of APP by an enzyme called alpha-secretase produces an alternative, non-toxic p...
Explaining a link between strokes and Alzheimer's
...the increased production of a toxic protein called amyloid
which builds up in the brains of people with Alzheimers. The work at Leeds is part of a network of research projects nationally and internationally, which are adding to the sum of knowledge about a disease which costs the UK more than cancer, heart...
MU researchers find mechanisms that may unlock answers to Alzheimer's disease
...yloid-beta peptide or A-beta, which accumulates in amyloid
plaques in the brain of Alzheimers patients. Despite unknown mechanisms, increased production of this peptide may cause impairments of brain functions. When the A-beta protein comes together inside the plaque, it will fold into an abnormal shape th...
Blocking stress protein decreases Alzheimer's peptide in mice
...e. They are mostly comprised of a peptide known as amyloid
beta, so researchers immediately suspected that stress was increasing amyloid
beta levels. But because there are other factors that can accelerate plaque build-up, they needed to...
Brain inflammation may be friend, not foe, for Alzheimer's patients
...ed to see the telltale clumps of material known as amyloid
plaques, made up of the peptide amyloid
beta, worsen. Instead, to the teams surprise, the brains of the mice with IL-1beta stuck in overdriv...
Breakdown of myelin implicated in Alzheimer's, UCLA research shows
...been associated with Alzheimer's disease. These amyloid
products in turn destroy more and more myelin, acc... iron, which promotes the development of the toxic amyloid
oligomers and plaques, which in turn destroy more myelin. Bartzokis tested his hypothesis by exami...
Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level
... studied the harmful rope-like structures known as amyloid
fibrils--linked protein molecules that form in the... each disease, a different protein transforms into amyloid
fibrils, but all of these diseases are similar at the molecular level," Eisenberg said. If the mol...
Research could lead to treatment for Alzheimer's disease
... the first step in a chain of events that leads to amyloid
plaque formation in the brain. The material at var...on of this enzyme on a special protein, called the amyloid
precursor protein, leads to the formation of plaques in the brain. The development of an inhibitor c...
Blocking immune cell action increases Alzheimer's-associated protein deposits
...tors involved in the immune cells' accumulation at amyloid
plaques. The research team focused on a molecul...od vessels similar to a condition called cerebral amyloid
angiopathy, which is associated with an increased risk of cerebral hemorrhage. In addition, CCR2-de...
Common anesthetic may induce cell death, generation of Alzheimer's-associated protein
...c to brain cells. A-beta is formed when the larger amyloid
precursor protein (APP) is clipped by two enzymes -- beta-secretase, also known as BACE, and gamma-secretase -- to release the A-beta fragment. Normal processing of APP by an enzyme called alpha-secretase produces an alternative, non-toxic protein. ...
Transdermal vaccine effective in treating Alzheimer's disease in mouse model
...any groups have shown vaccinating against the beta amyloid
protein (Ab) can reduce Alzheimer's-like pathology...id, "we believe clinical trials to evaluate a beta amyloid
skin patch or topical cream in patients with Alzheimer's would be warranted."...
New imaging technique identifies people-at-risk for Alzheimer's disease
...ented at UCLA that binds to the abnormal proteins amyloid
plaques and tangles that may cause the disease. Previously only an autopsy could determine these deposits and confirm a definitive diagnosis. Study results found that the new method was able to track disease progression over a two-year period and...
New study finds treatment with certain anti-hypertensive drugs may reduce Alzheimer's disease
...agents capable of preventing cognitive decline and amyloid
neuropathology associated with Alzheimers disease....etically predisposed to develop Alzheimers disease amyloid
neuropathology. The brain cells in vitro were then monitored to systematically assess the potential ...
New alzheimer's drug shows promise in clinical trial
...o create an Alzheimer's treatment that attacks the amyloid
peptide, which is considered to be the molecular cause of the disease," said Aisen. "This is the most advanced anti-amyloid treatment that exists--it has the potential for slowing down progression of the disease." Aisen and his team are currently in...
Alzheimer's alarm over anesthetics
...ey may also directly affect the rate at which beta amyloid
proteins bind together. This could be worrying, as...alothane and isoflurane encourage clumping of beta amyloid
protein, as does the commonly used intravenousanaesthetic propofol, at least at higher concentration...
Chemical found in curry may help immune system clear amyloid plaques found in Alzheimer's disease
...c -- may help the immune system clear the brain of amyloid
beta, which form the plaques found in Alzheimer's ...in and body, gobbling up waste products, including amyloid
beta. The team treated the macrophages with a drug derived from curcumin for 24 hours in a cell ...
Optics tests for early Alzheimer's diagnosis make significant advances
...hat could detect unusual cataracts composed of the amyloid
beta protein, the same molecules that are the hall... that manifests itself in the lens of the eye. The amyloid
beta proteins that form plaques in the brain and impair cognitive function also build up near the ed...
Insulin receptor stops progression of Alzheimer's disease
...AR alpha and PPAR gamma were effective in reducing amyloid
gene expression. PPAR delta had the most benefit for reducing oxidative stress and improving learning and memory. "That was the most spectacular," de la Monte says, "because everybody wants something for cognitive impairment, and that was the most i...
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