Reanalysis of controversial meta-analysis says writing off rosiglitazone may be premature
..., M.D., and Sanjay Kaul, M.D., describe additional analyses that provide different perspectives on rosiglitazone's safety issues. "Uncertain Effects of Rosiglitazone on the Risk of Myocardial Infarction and Cardiovascular Death" appeared online Aug. 7. Both physicians testified Monday, July 30, before a Foo...ADHD appears to be associated with depressed dopamine activity in the brain
...sociated with symptoms of inattention. Exploratory analyses also found evidence of reduced [11C]raclopride binding in the hippocampus and amygdala in those with ADHD. These areas of the brain are part of the limbic system, involved in emotional responses as well as consolidating and retrieving memories. The...Children and young people show elevated leukaemia rates near nuclear facilities
...thods and draw wider conclusions. Eight separate analyses were performed including unadjusted, random and fixed effect models and the figures they produced showed considerable consistency. But the authors point out that dose-response studies they looked at - which describe how an organism is affected b......device measures electrical signals from the heart, analyses them to produce an electrocardiogram (ECG) and sends an alert together with the ECG by cell phone text message. Cardiovascular disease is kills almost 20 million people each year, with around 22 million people at risk of sudden heart failure at any...Research probes seniors' plans for end-of-life care
...otional factors." Carr and Khodyakov based their analyses on data from the Wisconsin Longitudinal Study (WLS), a unique 50-year study of more than 10,000 men and women, now in their mid-60s, who graduated from Wisconsin high schools in 1957. In 2003-04, a random subsample of more than 7,000 WLS participants...DFG approves 11 new Collaborative Research Centers
...cular Transformations will address. The structural analyses that are planned will be made possible by combining chemistry and biochemistry with theoretical chemistry and physics, as well as the application of state-of-the-art ultra-fast methods and high-precision theoretical procedures. (Host university: Ludw...Extra pay does not improve hospital performance
...ity improvement effort. This is one of the first analyses of the impact of a pay for performance initiative on heart attack care, said Seth Glickman, M.D., M.B.A., first author of a paper appearing June 6, 2007, in the Journal of the American Medical Association. We found that the pay-for-performance progra...Study examines characteristics of female high school students who report steroid use
... prevalence of teen girls using steroids. Previous analyses of female steroid use have focused on older women and found an association with competitive athletics and bodybuilding. Diane L. Elliot, M.D., of the Oregon Health & Science University, Portland, and colleagues assessed anabolic steroid use among t...Genetic variations may predispose some men to suicidal thoughts during treatment for depression
...t in women. The researchers performed additional analyses suggesting these variations are not linked to suicidal thoughts and behaviors in men before treatment. No statistically significant association was noted between any SNP and the presence or absence of baseline suicidality, the authors write. Likewise...Brain-boosting pill alleviates post-chemotherapy fogginess
...sitive effect on fatigue, they conducted secondary analyses to assess whether modafinil could improve the breast cancer patients memory and attention skills. Results showed the women had a faster memory and could more accurately recognize words and pictures after four weeks on the drug. The ability to focus...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
... analysis included subjects from both groups. The analyses were supported by Novacea Inc., the sponsor of the ASCENT study. This new finding was in collaboration with Novacea. The results of ASCENT were published February 20, 2007 in the Journal of Clinical Oncology. . The most significant finding from t......ng the specific data necessary to perform the tree analyses and other problems of "what-if" risk analysis in a speedy and -- above all -- in a uniform way. ISI insights and inventions around the "semantic web," -- systematic structuring of database information to make it more accessible over the Internet --...NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
...enters (ACRC) will present substudies and subgroup analyses for three ACRC studies, and will present an overview of ongoing and future ACRC studies. The ACRC presentation will take place on Sunday, May 20th from noon to 1 p.m. in room 133 at the Moscone Center. NHLBI Asthma Clinical Research Networks T...Small infants have greater survival rate in high level intensive care facilities
...ewborn deaths may be preventable. Based on their analyses of California birth records, the researchers reported that less than a quarter of very low birth weight infants are born in hospitals with high-level, high-volume NICUs, and this percentage has been declining over time. The study examined difference...New long-term data analyses for Bifeprunox show favorable effects vs. placebo
...eting of the American Psychiatric Association. New analyses of six-month data in stabilized adult patients wit...prunox data presented at the meeting follows: In analyses of data from one Phase 3, six-month, randomized, double-blind, placebo-controlled study: Compare...Ulcerative colitis remission rates from long-term safety study of LIALDA presented at DDW
... endpoints of study 303 were presented as post-hoc analyses at Digestive Disease Week (DDW). Approved by the FDA on January 16, 2007, for the induction of remission in patients with active, mild to moderate UC, LIALDA is the first and only oral once-daily mesalamine on the market. Safety and effectiveness h...Persistent smokers may have higher risk to become depressed than never smokers
...ictor of depressive symptoms measured in 1990. The analyses were adjusted for other factors known to predict depression. Because the data consisted of twins it was possible to test the causality between smoking and depression by using twin pairs discordant for depression, where the twin without depression ser...Tobacco and alcohol use independently increase risk of head and neck cancer
...never smokers. The major strength of our pooled analyses was assembly of a very large series of never users of tobacco and never drinkers among head and neck cancer patients and control subjects, which allowed us to examine head and neck cancer risks in detail and to explore differences in risks by cancer ...One pill may be better than two for treating patients with high blood pressure
... effective as the two-tablet regimen. Sensitivity analyses confirmed these results when varying the effectiveness associated with partial adherence from 0 percent to 100 percent of the effectiveness of full adherence. Researchers in the ValueMedics study used U.S. databases to estimate direct medical costs a...Panel offers expert analysis on causes, prevention of stent thrombosis
...ared to bare metal stents. However, several recent analyses that tracked patient outcomes for four to five years after stent placement showed that blood clots were slightly more likely to form inside drug-eluting stents than inside bare metal stents. It is not yet clear how large the difference in risk is, bu...