Johns Hopkins researchers discover key protein linked to transverse myelitis and multiple sclerosis
... the severity of paralysis. Using cell culture and animal studies, the researchers confirmed that elevated IL-6 levels were directly injurious to the spinal cord. They showed that spinal fluid from TM patients induced death of spinal cord cells when cultured in a dish and that IL-6, when infused in adult ra...Change in focus needed for progress in HIV-vaccine research
...with vaccine design and the lack of a truly useful animal model for studying HIV infection. Despite these problems Gallo states that it is not time to give up on HIV vaccines. He argues that in order to progress there should be a shift in emphasis to rational approaches that are based on solid knowledge of ...New blood transplant method stops fatal side effect, Stanford study finds
...s that it is a practical example of translating an animal model to the clinic," said Lowsky. THE MARATHON MAN Holmes is certainly glad that he could benefit from the trial. He had been referred to Stanford for a blood stem cell transplantation in July 2004. It had been six years since, at age 38, he had n...MGH named by NHLBI as Specialized Center for Cell-Based Therapy for Heart, Lung and Blood Diseases
...ach can dramatically affect tissue regeneration in animal models, leading to the current effort to extend the concept to human patients. "We hope to provide proof of principle that we can influence stem cell activity by manipulating these microenvironments with medications," Scadden says. "We'll initially ...National funding goes to Johns Hopkins to advance research on stem cell therapies for heart attack
...ls. The second project continues with preclinical animal and laboratory research, required by the Food and Drug Administration before new therapies can be approved for initial testing. The laboratory research group will be led by Marbn, whose team will study the potential of using a patient's own cardiac s...Adult stem cells aid recovery in animal model of cerebral palsy
...ficantly improves recovery of motor function in an animal model for the ischemic brain injury that occurs in...cells were injected directly into the brains of 22 animal models through a tiny hole in the skull. As with human transplant recipients, the animals were plac...Researchers shed light on anxiety and alcohol intake
...ed compounds to these phenomena in P rats or other animal models."...Amoxicillin use during infancy may be linked to tooth enamel defects
...oratory and clinical studies--including controlled animal studies with specified amoxicillin dosages, chemical analysis and histological examination of affected teeth, and additional well-designed epidemiological studies--are needed to confirm the results. "The findings suggest that amoxicillin use in infan...American Thoracic Society journal news tips for October 2005 (first issue)
...riggered by many stimuli, including pollens, mold, animal dander, and dust mites. During the study, exhaled ...mportant in recovering from acute lung injury. In animal models, bone marrow-derived EPCs differentiate into mature endothelium and assist in repairing a dam...Independent panel to evaluate a chemical used in some plastics for hazards to human health
...edical tubing and other devices, has been shown in animal studies to be hazardous at high levels of exposure. Vulnerable populations such as critically ill newborns may be exposed to higher levels than the general population due to the extensive medical procedures they undergo. Since the review of DEHP by ...Other highlights in the October 5 JNCI
...stigate associations between intake of meat, other animal products, fat, and cholesterol and pancreatic cancer risk, Ute Nthlings, Dr.P.H., of the Cancer Research Center of Hawaii in Honolulu, and colleagues analyzed data from the prospective Multiethnic Cohort Study. During 7 years of follow-up, 482 cases ...New model shows gender differences in high blood pressure, Jefferson scientists find
...pled protein receptor kinase, was known to rise in animal models with high blood pressure. According to Dr. Eckhart, this kinase acts as a switch that essentially turns off receptors. Such receptors bind catecholamines, which are sympathetic system neurotransmitters like epinephrine and norepineprhine. They...UK foot and mouth epidemic was a human tragedy, not just an animal one
... disease epidemic was a human tragedy, not just an animal one, concludes a study published online by the BMJ... year. But because the epidemic was treated as an animal problem, little is known about the human cost of the disaster. Researchers from Lancaster Universit...Scientists pinpoint inflammation gene
...company that initially identified the gene through animal studies and funded this latest analysis of its rol... The company was studying the desert sand rat, an animal that, like humans, has certain individuals with a greater propensity than others for obesity and dia...Immune therapy could treat leukemias, autoimmune diseases, transplant rejection
...d on the surface of B cells. As their experimental animal models, they used mice that had been genetically a.... According to Tedder, the results of the CD19 mAb animal studies warrant rapid advance to clinical trials for treatment of B cell leukemias and other maligna...Notch signaling molecule important in type 2 immunity
...ing specifically influences Th2 immunity in a live animal when challenged with a pathogen, suggesting that drugs that inhibit Notch may be useful for treating diseases associated with a pathological Th2 response, such as asthma," says Pear. He is also a member of Penn's Abramson Family Cancer Research Insti...Inhaled nitric oxide may help sickle cell disease
...tudies by Dr. Head and his colleagues in a hypoxic animal model for sickle cell disease showed the animals who breathed nitric oxide gas are the ones that survived. "This is not a cure, but we think it will get patients out of a crisis earlier or maybe prevent a crisis," says Dr. Head of the potential thera...Asthma home intervention cost-effective for inner-city children, research reveals
...ffectively remove cockroach droppings, dust mites, animal dander and other dirt that can trigger asthma attacks in susceptible people. The cost per symptom-free day for each child was $25.57, investigators found. Asthmatic children in the study used 13 percent fewer B-agonist inhalers for relieving symptoms...UCLA/VA research analysis in journal Nature explains wide variations in animal sleep habits
...ls safe by restricting waking to the hours when an animal is most likely to be successful at finding food and avoiding danger. Human sleep follows the rules that determine sleep time in other animals, the analysis concludes. Humans sleep somewhat less than animals with similar physiological features, sugges......ise, which confirms the observations made in prior animal studies but has not been previously shown in humans," notes Dr. Dahlberg. "The changes imply that human cartilage responds to physiologic loading in a way similar to that exhibited by muscle and bone, and that previously established positive symptom...