Clinical trials with immunotherapy for breast and colorectal cancer
.... Come over here and destroy them." The laboratory animal studies conducted by Dr. Woo and colleagues have p... not lead to a sustained infection in patients. In animal experiments we have found that this maximizes both effectiveness and safety, and we hope to see the ...Reagent under study as cancer vaccine may also help protect tumors
...cal College of Georgia Immunotherapy Center. In an animal model, Dr. Mellor and his colleagues have found CpG-ODNs also can trigger a mechanism that may have helped the tumor survive in the first place: expression of an enzyme that enables it to hide from the immune system. "What we have found is the abilit...Binghamton University psychologist honored by NIH for alcohol, developing brain research
...le first drink alcohol. Spear's investigations use animal models to identify factors that might contribute to adolescents' propensity to experiment with alcohol and to determine why this age group seems to be at particular risk for alcohol's deleterious effects. Her findings are helping scientists understan...Successful tests of new treatments in mice for eye disease causing irreversible blindness in humans
...ntary means for restoring retinal function in this animal model of human hereditary blindness." The disease studied is Leber congenital amaurosis (LCA), characterized by severe loss of vision at birth. Its causes are not fully understood. Researchers believe that the disease might be due to abnormal develo...Causes of primary biliary cirrhosis
...ase for PBC patients and family members as well as animal studies with the identified agents. "Only these combined efforts will provide the solution to the enigma of PBC etiology," they say....New therapeutic target identified in inherited brain tumor disorder
...ss of drugs to control brain tumor growth in small animal models is planned. "This agent and others like it have already been in clinical trials as treatments for other tumors, so if we find that fumagillin inhibits brain tumor growth in preclinical studies, it will be a much smaller leap to using these co...Combination microbicides protect monkeys against HIV-like virus
.... Fauci, M.D. "We need to build on these promising animal studies and move toward establishing the safety and effectiveness of combination microbicides in women." Vaginal microbicides include creams, gels or other substances that could be applied topically to prevent the transmission of HIV and other sexua...Vitamin D, taxotere combination extends the lives of men with advanced prostate cancer
...s, producing anti-tumor activity in laboratory and animal models. ASCENT was designed to confirm results from a small, phase II OHSU study led by Beer that showed dramatic PSA reductions in subjects who took high doses of calcitriol with chemotherapy. In the phase II study, subjects were taking as many as...Tryptophan no turkey in boosting immune system, Stanford study shows
...n plays a pivotal role in the immune system. In an animal model, Steinman's group has found that certain tryptophan metabolites - molecules formed as the body breaks down the amino acid - work as well as any other existing medicines to alleviate multiple sclerosis symptoms. In multiple sclerosis, the immune...Penn researchers study the use of ultrasound for treatment of cancer
...) For the first time, ultrasound is being used in animal models to treat cancer by disrupting tumor blood vessels. Researchers at the University of Pennsylvania School of Medicine completed a study in mice in which they used ultrasound both to see a tumor's blood perfusion and then to treat it with a cont...Study broadens understanding of enzymes linked to tumor promoting molecule
...are essential components of cell membranes for all animal and plant cells. "These results highlight the importance of designing inhibitors of exquisite selectivity. Our findings highlight some critical information - just because two enzymes catalyze the same reaction does not mean that targeting one will h...A recipe for overeating: Studies outline dangers of mixing stress, deprivation and tempting foods
...ify the different variables involved in controlled animal studies. Working with laboratory rats, the resear...tivity depends not on food type but on whether the animal has had enough to eat (homeostatic state). As for actual intake, when presented with the Choc and C...Increased suicide rate with possible link to nearby industry chemicals in second N.C. community
...I think it has to be explored," Weisler added. In animal studies, hydrogen sulfide has been shown to be a neurotoxin, altering levels of brain chemicals such as serotonin, norepinephrine, dopamine, aspartate, GABA and glutamate, the authors reported. "We speculate that hydrogen sulfide may serve as a marke...Aspirin might prevent development of oesophageal adenocarcinoma
...enzyme with tumour-promoting properties. Human and animal studies have suggested these drugs might have a role in preventing neoplastic progression in oesophageal adenocarcinoma. Vaughan and colleagues therefore investigated prospectively the relation between the duration, frequency, and recency of NSAID u...The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient
...hough, most studies in this country are limited to animal models, but a case study about D.H., which was published in the recent issue of the Nutrition and Cancer journal, could be a major step forward for human clinical trials. While beginning to take high dose of fish oil and golden algae oil capsules da...Drug not effective in preventing bypass vein clogging
...e activation. The drug appeared to be promising in animal models and two small clinical trials involving 41 and 200 patients, said the researchers. The latest randomized, double-blind trial, known as PREVENT-IV, enrolled 3,014 patients at 107 U.S. sites who underwent coronary artery bypass graft procedures ...Gene therapy potential for treatment of pancreatic cancer
...ls. This effect was seen in both the test tube and animal experiments. This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic cancer, and represents a promising therapeutic option for malignancy with a poor prognosis," conclude the authors....Timing possible treatments against Alzheimer's disease
... did not go away either. As always, results from animal models cannot simply be extrapolated to human disease. However, this study suggests that treatment with drugs that lower production of Abeta can prevent progression of AD but not reverse the disease. While overall encouraging, the results emphasize t...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
...gues would like to plan studies looking at another animal model system to find out if fullerene not only protects the entire animal from radiation, but to also examine organ-specific effects, such as protecting the lungs, for exampl...Healthy diets rich in protein and good fat, and lower in carbs linked to better heart health
...all, the protein-rich diet, derived from plant and animal sources, decreased cardiovascular disease risk by 21 percent. "Many people equate protein with meat, but it is not the only source of protein," says study co-author Phyllis McCarron, M.S., R.D., a dietitian at Hopkins. "Excellent plant sources of pro...