Six organizations vie for INFORMS 'science of better' innovation prize
...Antifolates are among the most promising potential anticancer agents but they carry varied risks of toxicity; although rarely occurring, the combination of toxicities can result in death. Eli Lily was forced to halt clinical development of its antifolate ALIMTA, despite observed anti-tumor activity and more tha...Spice it up or just veg out, either way you may be helping to defend against cancer
...flammatory activities, and found that it exhibited anticancer activity against pancreatic cancer cells. Pancreat...Our results demonstrate that capsaicin is a potent anticancer agent, induces apoptosis in cancer cells and produces no significant damage to normal pancreatic cel...Combination chemotherapy shows small survival benefit in advanced stomach cancer
... for 2006, researchers will examine the effects of anticancer therapies still in clinical trials that specifically target stomach cancer cells...Jefferson scientists create plant factories churning out antibodies against tumor cells
...e to provide a cheaper, faster method of producing anticancer antibodies, raising hopes that the technology can one day be used in humans. Scientists, led by Hilary Koprowski, M.D., professor of microbiology and immunology and director of the Biotechnology Foundation Laboratories and the Center for Neurovirolo...New kidney cancer drug response rate is more than double that of standard treatment
Orlando, May 14, 2005 Recent studies of a new anticancer drug show continued response for patients with late-stage kidney cancer. Robert Motzer, MD, attending physician at Memorial Sloan-Kettering Cancer Center (MSKCC), reported a response rate of 40 percent in patients with metastatic (advanced) renal cel...Researchers prevent post-traumatic brain damage
... model of traumatic brain injury. Flavopiridol, an anticancer drug, has already been tested in humans, but has not been proven successful because of the toxicity associated with sustained use, said Di Giovanni. But the researchers thought that it might work, and with limited side effects, if the drug was used j...Children need better cancer drugs, says expert panel
...natural products, services to screen compounds for anticancer activity, drug discovery databases, and programs t...nt, industry and academia to produce new pediatric anticancer drugs. It suggests that in cases where companies do not proceed to full development of promising ped...Derivatives of cannabis for anti-cancer treatment win Kaye Award for Hebrew University student
...he development of quinonoid compounds that display anticancer activity, but are less toxic, is a major therapeutic goal. At present, Kogan is continuing to investigate the mechanism of action of these promising compounds. All of the compounds synthesized by Kogan inhibited cancer cell growth in cell culture, a...Omega-3 offers hope for new anti-breast cancer drugs
...es for a longer duration and therefore enhance its anticancer effects". Omega-3 fatty acids, like those found in oily fish such as tuna, salmon, herring, sardines and mackerel, are already known to have many positive health benefits. They are commonly recommended for maintaining a healthy heart, as they are kno...Nanoparticles carry cancer-killing drugs into tumor cells
...ies in cell cultures have suggested that attaching anticancer drugs to nanoparticles for targeted delivery to tu..., U-M scientists attached methotrexate, a powerful anticancer drug, to branches of the dendrimer. On other branches, they attached fluorescent imaging agents and ...Transplantation of sperm stem cells restores fertility after chemotherapy
...o treat the infertility that arises as a result of anticancer treatment for childhood leukemia. A number of issues surrounding the harvest of such material from prepubertal children with leukemia, that could be safely stored and retransplanted into chemotherapy-damaged testes, have not yet been solved. These in...Potent spice works to block growth of melanoma in lab test
... is the latest to suggest that curcumin has potent anticancer powers, say the researchers. "The antioxidant, anti-inflammatory and anti-carcinogenic properties of curcumin derived from turmeric are undergoing intense research here and at other places worldwide," says one of the study's authors, Bharat B. Aggarw...Single dose of chemotherapy is as effective as radiotherapy for testicular cancer
One-day treatment with the anticancer drug carboplatin is as effective and less toxic than three weeks radiation therapy for a type of testicular cancer, according to a report published in this week's issue of THE LANCET. For the last 50 years standard care for stage 1 seminoma--a cance...Major NH&MRC grant will fund multidisciplinary research to improve the treatment of neuroblastoma
...ity to inhibit target genes; and translate novel anticancer therapies into clinical applications. The funding will enable researchers to expand their groundbreaking work on the role of Multidrug Resistance-associated protein-1 (MRP1), the oncogene MYCN and the retinoic acid receptor. Retinoic acid is a Vitam...Anti-tumor activity also plays a critical role during eye development in the embryo
...ng eye might also contribute to development of new anticancer drugs. "If we can figure out how to re-activate the Arf gene in human cancers in which this gene is repressed, we might be able to prevent the accumulation of perivascular cells that support the blood vessels that feed a tumor," Skapek said. "A drug ......on-myeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia. Similar indications for Neulasta were approved in Europe and Australia the same year. Rare cases of splenic rupture and sickle cell crises have been reported in postmar...Hopkins geneticist discovers mutations in cancer cells that suggest new forms of treatment
...tor tyrosine kinases sit on the cell surface where anticancer drugs can get at them," said Gregory J. Riggins, M.D., co-lead author of the study and an associate professor in the Department of Neurosurgery at The Johns Hopkins University School of Medicine. In the study, published in the October 4th edition of ...Retinoblastoma researchers find success with two-drug combination
...ith retinoblastoma in both eyes often must undergo anticancer therapy in order to avoid the loss of both eyes and blindness. But despite the critical need for new treatments that are more effective and have less severe side effects, researchers have been limited in their ability to identify new drugs and drug c...No good evidence that cholesterol drugs lower melanoma risk
... high cholesterol hinted that the drugs might have anticancer properties.Dellavalle said the review "does not ex...ibrates may slow or stop tumor growth or boost the anticancer effects of chemotherapy, Dellavalle and colleagues say. "Each statin has slightly different chemistr...Compound from marine bacteria shows potential as multiple myeloma therapy
...om the ocean floor. The substance has shown strong anticancer properties in laboratory tests. Nereus Pharmaceuticals holds an exclusive license to the compound for drug development. Experiments with NPI-0052 began at Dana-Farber in 2003, said Dharminder Chauhan, PhD, lead author of the paper along with Laure...