Tag: "antifolate" at medical news
Six organizations vie for INFORMS 'science of better' innovation prize
...ily was forced to halt clinical development of its antifolate
ALIMTA, despite observed anti-tumor activity and more than $300 million invested. Operations research helped Eli Lilly resume testing. In addition to collecting standard clinical data, Eli Lilly researchers in the phase 2 clinical development of AL...
Antifolate therapies found effective against certain type of malaria
...ues tested the relative efficacy and safety of two antifolate
drugs (sulfadoxine-pyrimethamine and chlorproguanil-dapsone) against P vivax malaria and compared each with chloroquine. There are an estimated 70 million to 80 million cases of P vivax each year, accounting for more than 50 percent of all malaria ca...
Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
...(Erbitux) and vandetanib (Zactima). ALIMTA is an antifolate
which interferes with a crucial process that allows cancer cells to reproduce and spread. The most common side effects when ALIMTA is used as monotherapy are disorders of the blood and lymphatic system, gastrointestinal disorders, fatigue, rash and d...